Additional file 2.

Progression of bone repair in control and Nf1Prx1 mice, 28 days post injury. Toluidine/VonKossa stained transverse sections of the cortical defect area. After 28 days post injury the cortical structure is regenerated in control mice (left). The cortical bone in mutant mice remains thinned and overlaid by a thick osteoid (red arrows). It is also excessively penetrated by blood vessels (white arrows).

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Kolanczyk et al. BMC Medicine 2008 6:21   doi:10.1186/1741-7015-6-21