Table 1

Differentially expressed microRNAs in anaplastic astrocytoma and/or glioblastoma multiforme tumors relative to non-neoplastic brain tissue

Glioblastoma multiforme and anaplastic astrocytoma

Glioblastoma multiforme only

Anaplastic astrocytoma only


Fold change glioblastoma multiforme

Fold change anaplastic astrocytoma

Ref

Fold change glioblastoma multiforme

Ref

Fold change anaplastic astrocytoma

Ref


Down-regulated

Down-regulated

Down-regulated

miR-7

34

13

miR-101

4

miR-125b

153

[22]

miR-31

17

9

miR-128a

27

[22]

miR-126

7

miR-107

14

10

miR-132

7

miR-127

149

miR-124

57

26

miR-133a

17

miR-134

9

miR-124b

45

27

miR-133b

14

miR-129

43

27

miR-149

9

Up-regulated

miR-137

63

66

miR-153

12

miR-296

11

miR-138

27

12

[21]

miR-154*

7

miR-320

5

miR-139

66

34

miR-185

5

miR-187

6

5

miR-29b

6

miR-203

13

4

miR-323

17

miR-218

40

16

miR-328

8

miR-330

18

Up-regulated

miR-10b

35

75

[22]

Up-regulated

miR-21

7

[21,22]

miR-155

8

miR-210

7


P-values for all miRNAs are P < 0.05 for comparisons of miRNA expression in tumors versus glioses; for miRNAs in bold P < 0.01. References indicate high-grade astrocytoma miRNA expression studies in which miRNA has been described previously.

Silber et al. BMC Medicine 2008 6:14   doi:10.1186/1741-7015-6-14

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