Open Access Highly Accessed Research article

miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells

Joachim Silber1, Daniel A Lim1, Claudia Petritsch1, Anders I Persson23, Alika K Maunakea1, Mamie Yu1, Scott R Vandenberg4, David G Ginzinger5, C David James1, Joseph F Costello1, Gabriele Bergers1, William A Weiss23, Arturo Alvarez-Buylla1 and J Graeme Hodgson1*

Author Affiliations

1 Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA

2 Department of Neurology, University of California San Francisco, San Francisco, CA, USA

3 Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA

4 Department of Pathology, University of California San Francisco, San Francisco, CA, USA

5 Applied Biosystems, Foster City, CA, USA

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BMC Medicine 2008, 6:14  doi:10.1186/1741-7015-6-14

Published: 24 June 2008

Additional files

Additional file 1:

Characteristics of the patient tissues used in this study.

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Additional file 2:

Validation of miR-124 expression and function in glioblastoma multiforme cells.

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Additional file 3:

Supplementary methods. This pdf file provides further details related to the methods used in this study.

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Additional file 4:

Log2 fold change of microRNAs in non-tumor brain samples (glioses), anaplastic astrocytomas and glioblastoma multiforme tumors.

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Additional file 5:

Validation of let-7a and miR-16 as appropriate control miRNAs in primary tumor samples and neural stem cells.

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Additional file 6:

Statistical comparisons of miRNA expression in glioblastoma multiforme and anaplastic astrocytoma tumors versus non-tumor brain tissue (gliosis).

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Additional file 7:

Assessment of miR-124a and miR-137 expression in mouse oligodendroglial stem cells.

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Additional file 8:

miR expression in glioblastoma multiforme cell lines following treatment with DNA demethylating and deacetylating agents

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