Table 1 |
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|
Characteristics of selected trials |
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|
Author (year) |
Trial name |
Participants |
Sample size |
Mean age at baseline (year) |
Current smoker (%) |
Male (%) |
Follow-up (year) |
Aspirin dose (mg/day) |
|
|
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|
Ridker et al [26] (2005) |
Women's Health Study (WHS) |
Healthy women ≥ 45 years in USA |
39 876 |
55 |
13 |
0 |
10.0 |
100† |
|
de Gaetano [19] (2001) |
Primary Prevention Project (PPP) |
Patients with at least one of the major recognized cardiovascular risk factors in Italy |
4 495 |
64 |
15 |
42 |
3.6 |
100 |
|
Cote et al [18] (1995) |
Asymptomatic Cervical Bruit Study (ACBS) |
Patients with asymptomatic carotid stenosis in Canada |
372 |
67 |
37 |
45 |
2.3 |
325 |
|
ETDRS Study Group [13] (1992) |
Early Treatment Diabetic Retinopathy Study report (ETDRS) |
Patients with a clinical diagnosis of diabetes mellitus |
3 711 |
18–70 |
44# |
52 |
5.0 |
650 |
|
Juul-Moller et al [24] (1992) |
Swedish Angina Pectoris Aspirin Trial (SAPAT) |
Patients with chronic stable angina |
2 035 |
67 |
16 |
52 |
4.2 |
75 |
|
Hansson et al [23] (1998) |
Hypertension Optimal Treatment Study (HOT) |
Patients with hypertension and diastolic blood pressure between 100 mmHg and 115 mmHg from countries in Europe, America, and Asia |
18 790 |
62 |
16 |
53 |
3.8 |
75 |
|
Swedish cooperative [8] (1987) |
Swedish Cooperative Study (Swedish Coop) |
Patients with cerebral infarction, minor or major stroke |
505 |
68 |
52 |
62 |
2.0 |
1 500 |
|
EAFT Study Group [14] (1993) |
European Atrial Fibrillation Trial (EAFT) |
Patients with non-rheumatic atrial fibrillation |
782* |
73 |
19 |
63 |
2.3 |
300 |
|
SALT Collaborative Group [11] (1991) |
Swedish Aspirin Low-Dose Trial (SALT) |
Patients after transient ischaemic attack (TIA) or minor stroke |
1 360 |
67 |
25 |
66 |
2.7 |
75 |
|
Cairns et al [17] (1985) |
Canadian multicenter trial (Canadian) |
Patients with unstable angina who were hospitalized in coronary care units in Canada |
278* |
57 |
35 |
70 |
1.5 |
1 300 |
|
Stroke Prevention in Atrial Fibrillation Study group [12] (1991) |
Stroke Prevention in Atrial Fibrillation Study (SPAF) |
Patients with constant or intermittent atrial fibrillation |
1 120* |
67 |
16 |
71 |
1.3 |
325 |
|
Sorensen et al [27] (1983) |
A Danish cooperative study (Danish Coop) |
Patients experienced at least one reversible cerebral ischemic attack |
203 |
59 |
24¶ |
73 |
2.0 |
1 000 |
|
Farrell et al [22] (1991) |
United Kingdom transient ischaemic attack aspirin trial (UK-TIA) |
Patients with a transient ischaemic attack or minor ischaemic stroke |
2 435 |
60 |
53 |
73 |
4.0 |
300/1 200 |
|
Persantine-Aspirin Reinfarction Study Research Group [5] (1980) |
Persantine-aspirin Reinfarction Study (PARIS) |
Patients recovered from myocardial infarction |
1 216* |
56 |
27 |
77 |
3.4 |
972 |
|
Breddin et al [16] (1980) |
German-Austrian aspirin trial (GAAT) |
Patients who had survived a myocardial infarction for 30–42 days |
626 |
45–70 |
58 |
78 |
2.0 |
1 500 |
|
Elwood and Sweetnam [21] (1979) |
Aspirin and secondary mortality after myocardial infarction (Cardiff-II) |
Patients with confirmed myocardial infarction |
1 725‡ |
56 |
60 |
85 |
1.0 |
900 |
|
AMIS Study Group [6] (1980) |
Aspirin myocardial infarction study (AMIS) |
Patients experienced at least one myocardial infarction in USA |
4 524 |
55 |
27 |
89 |
3.0 |
1 000 |
|
Elwood et al [20] (1974) |
Secondary prevention of mortality from myocardial infarction (Cardiff-I) |
Patients with recent myocardial infarction |
1 239‡ |
55 |
NA |
100 |
1.1 |
300 |
|
Coronary Drug Project Research Group [7] (1980) |
Coronary Drug Project Aspirin Study (CDPA) |
Patients with a history of myocardial infarction |
1 529‡ |
NA |
NA |
100 |
1.8 |
324 |
|
Lewis et al [25] (1983) |
Veterans Administration Cooperative Study (VACS) |
Patients with unstable angina in USA |
1 266 |
56 |
50 |
100 |
1.0 |
324 |
|
Steering Committee of the Physicians' Health Study Research Group [9] (1989) |
Physicians' Health Study (PHS) |
Healthy male physicians in USA |
22 071 |
52 |
11 |
100 |
5.0 |
325† |
|
The RISC Group [10] (1990) |
Research Group on Instability in Coronary Artery Disease (RISC) |
Men with unstable coronary artery disease in Southeast Sweden |
796* |
58 |
38 |
100 |
1.0 |
75 |
|
Medical Research Council's General Practice Research Framework Group [15] (1998) |
Thrombosis prevention Trial (TPT) |
Patients at high risk of cardiovascular disease in UK |
2 540 |
58 |
41 |
100 |
4.0 |
75 |
|
|
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|
NA: not available. *Only the participants in placebo group and aspirin group were included. † Every other day. ‡ Data are from [4]. ¶ > 15 cigarettes/day. # ≥ 6 cigarettes/day. |
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|
Yerman et al. BMC Medicine 2007 5:29 doi:10.1186/1741-7015-5-29 |
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