Table 4

Models used for analysis of the effects of statins on incidence of Parkinson's disease using the Cox proportional survival method. (A) Atorvastatin; (B) lovastatin; (C) simvastatin. Model 1 included an adjustment for the interaction between PD and age. Model 2 included adjustments for the interaction between PD, three disorders associated with increased risk of PD and neuroleptic use. Model 3 included adjustments for the interaction between dementia, the Charlson Index and neuroleptic use. For the purpose of analysis of interactions with the Charlson Index, subjects with a Charlson Index of 0 or 1 were compared with those with a Charlson Index of ≥2. Cox Survival Models for Incidence of Parkinson's Disease. A. Atorvastatin vs CV Comparator


Model 1
Model 2
Model 3


Variable
HR
p value
95% Confidence limits for HR
HR
p value
95% Confidence limits for HR
HR
p value
95% Confidence limits for HR

Atorvastatin
0.90
0.15
0.79
1.04
0.96
0.59
0.84
1.11
0.99
0.90
0.86
1.14
     Versus CV




1.05
<0.0001
1.05
1.06
1.05
<0.0001
1.05
1.06
     Age




1.00
0.97
0.90
1.12




     Hypertension




1.18
<0.0001
1.09
1.27




     CVD




1.12
0.0059
1.03
1.21




     Diabetes




5.12
<0.0001
4.62
5.68
4.97
<0.0001
4.48
5.51
     Charlson Index








1.33
<0.0001
1.23
1.44
Lovastatin












     Versus CV
1.09
0.15
0.97
1.22
1.06
0.33
0.95
1.18
1.09
0.13
0.98
1.22
     Age




1.05
<0.0001
1.04
1.06
1.05
<0.0001
1.04
1.06
     Hypertension




0.99
0.85
0.81
1.10




     CVD




1.20
<0.0001
1.11
1.29




     Diabetes




1.13
0.0001
1.05
1.23




     Charlson Index




5.16
<0.0001
4.66
5.71
5.02
<0.0001
4.53
5.55
Simvastatin








1.32
<0.0001
1.22
1.43
     Versus CV












     Age
0.50
<0.0001
0.47
0.53
0.50
<0.0001
0.47
0.53
0.50
<0.0001
0.49
0.55
     Hypertension




1.05
<0.0001
1.05
1.06
1.05
<0.0001
1.05
1.06
     CVD




0.97
0.42
0.89
1.05




     Diabetes




1.21
<0.0001
1.14
1.28




     Charlson Index




1.11
0.0012
1.04
1.18




Atorvastatin




5.26
<0.0001
4.85
5.70
5.08
<0.0001
4.69
5.50
     Versus CV








1.44
<0.0001
1.36
1.53

HR, hazard ratio, CVD, cardiovacular disease, CV, cardiovascular.

Model 1 included an adjustment for the interaction between dementia and age; model 2 included adjustments for the interaction between dementia and three disorders associated with increased risk of dementia.; model 3 included adjustments for the interaction between dementia and the Charlson Index, which is an index that provides a broad assessment for the amount of chronic disease.

Wolozin et al. BMC Medicine 2007 5:20   doi:10.1186/1741-7015-5-20