Table 4

Models used for analysis of the effects of statins on incidence of Parkinson's disease using the Cox proportional survival method. (A) Atorvastatin; (B) lovastatin; (C) simvastatin. Model 1 included an adjustment for the interaction between PD and age. Model 2 included adjustments for the interaction between PD, three disorders associated with increased risk of PD and neuroleptic use. Model 3 included adjustments for the interaction between dementia, the Charlson Index and neuroleptic use. For the purpose of analysis of interactions with the Charlson Index, subjects with a Charlson Index of 0 or 1 were compared with those with a Charlson Index of ≥2. Cox Survival Models for Incidence of Parkinson's Disease. A. Atorvastatin vs CV Comparator

Model 1
 Model 2
 Model 3

Variable
 HR
 p value
 95% Confidence limits for HR
 HR
 p value
 95% Confidence limits for HR
 HR
 p value
 95% Confidence limits for HR
Atorvastatin
 0.90
 0.15
 0.79
 1.04
 0.96
 0.59
 0.84
 1.11
 0.99
 0.90
 0.86
 1.14
     Versus CV



1.05
 <0.0001
 1.05
 1.06
 1.05
 <0.0001
 1.05
 1.06
     Age



1.00
 0.97
 0.90
 1.12



     Hypertension



1.18
 <0.0001
 1.09
 1.27



     CVD



1.12
 0.0059
 1.03
 1.21



     Diabetes



5.12
 <0.0001
 4.62
 5.68
 4.97
 <0.0001
 4.48
 5.51
     Charlson Index







1.33
 <0.0001
 1.23
 1.44
Lovastatin











     Versus CV
 1.09
 0.15
 0.97
 1.22
 1.06
 0.33
 0.95
 1.18
 1.09
 0.13
 0.98
 1.22
     Age



1.05
 <0.0001
 1.04
 1.06
 1.05
 <0.0001
 1.04
 1.06
     Hypertension



0.99
 0.85
 0.81
 1.10



     CVD



1.20
 <0.0001
 1.11
 1.29



     Diabetes



1.13
 0.0001
 1.05
 1.23



     Charlson Index



5.16
 <0.0001
 4.66
 5.71
 5.02
 <0.0001
 4.53
 5.55
Simvastatin







1.32
 <0.0001
 1.22
 1.43
     Versus CV











     Age
 0.50
 <0.0001
 0.47
 0.53
 0.50
 <0.0001
 0.47
 0.53
 0.50
 <0.0001
 0.49
 0.55
     Hypertension



1.05
 <0.0001
 1.05
 1.06
 1.05
 <0.0001
 1.05
 1.06
     CVD



0.97
 0.42
 0.89
 1.05



     Diabetes



1.21
 <0.0001
 1.14
 1.28



     Charlson Index



1.11
 0.0012
 1.04
 1.18



Atorvastatin



5.26
 <0.0001
 4.85
 5.70
 5.08
 <0.0001
 4.69
 5.50
     Versus CV







1.44
 <0.0001
 1.36
 1.53

HR, hazard ratio, CVD, cardiovacular disease, CV, cardiovascular.

Model 1 included an adjustment for the interaction between dementia and age; model 2 included adjustments for the interaction between dementia and three disorders associated with increased risk of dementia.; model 3 included adjustments for the interaction between dementia and the Charlson Index, which is an index that provides a broad assessment for the amount of chronic disease.

Wolozin et al. BMC Medicine 2007 5:20   doi:10.1186/1741-7015-5-20