Table 4

Models used for analysis of the effects of statins on incidence of Parkinson's disease using the Cox proportional survival method. (A) Atorvastatin; (B) lovastatin; (C) simvastatin. Model 1 included an adjustment for the interaction between PD and age. Model 2 included adjustments for the interaction between PD, three disorders associated with increased risk of PD and neuroleptic use. Model 3 included adjustments for the interaction between dementia, the Charlson Index and neuroleptic use. For the purpose of analysis of interactions with the Charlson Index, subjects with a Charlson Index of 0 or 1 were compared with those with a Charlson Index of ≥2. Cox Survival Models for Incidence of Parkinson's Disease. A. Atorvastatin vs CV Comparator

Model 1

Model 2

Model 3

Variable

HR

p value

95% Confidence limits for HR

HR

p value

95% Confidence limits for HR

HR

p value

95% Confidence limits for HR

Atorvastatin

0.90

0.15

0.79

1.04

0.96

0.59

0.84

1.11

0.99

0.90

0.86

1.14

Versus CV

1.05

<0.0001

1.05

1.06

1.05

<0.0001

1.05

1.06

Age

1.00

0.97

0.90

1.12

Hypertension

1.18

<0.0001

1.09

1.27

CVD

1.12

0.0059

1.03

1.21

Diabetes

5.12

<0.0001

4.62

5.68

4.97

<0.0001

4.48

5.51

Charlson Index

1.33

<0.0001

1.23

1.44

Lovastatin

Versus CV

1.09

0.15

0.97

1.22

1.06

0.33

0.95

1.18

1.09

0.13

0.98

1.22

Age

1.05

<0.0001

1.04

1.06

1.05

<0.0001

1.04

1.06

Hypertension

0.99

0.85

0.81

1.10

CVD

1.20

<0.0001

1.11

1.29

Diabetes

1.13

0.0001

1.05

1.23

Charlson Index

5.16

<0.0001

4.66

5.71

5.02

<0.0001

4.53

5.55

Simvastatin

1.32

<0.0001

1.22

1.43

Versus CV

Age

0.50

<0.0001

0.47

0.53

0.50

<0.0001

0.47

0.53

0.50

<0.0001

0.49

0.55

Hypertension

1.05

<0.0001

1.05

1.06

1.05

<0.0001

1.05

1.06

CVD

0.97

0.42

0.89

1.05

Diabetes

1.21

<0.0001

1.14

1.28

Charlson Index

1.11

0.0012

1.04

1.18

Atorvastatin

5.26

<0.0001

4.85

5.70

5.08

<0.0001

4.69

5.50

Versus CV

1.44

<0.0001

1.36

1.53

HR, hazard ratio, CVD, cardiovacular disease, CV, cardiovascular.

Model 1 included an adjustment for the interaction between dementia and age; model 2 included adjustments for the interaction between dementia and three disorders associated with increased risk of dementia.; model 3 included adjustments for the interaction between dementia and the Charlson Index, which is an index that provides a broad assessment for the amount of chronic disease.

Wolozin et al. BMC Medicine 2007 5:20   doi:10.1186/1741-7015-5-20