Table 2

Serum alanine aminotransferase (ALT) measures (intent to treat analysis)

Serum ALT (IU/L)

Acetaminophen group

Placebo Group

p-value*

Day 0:

Mean ± SD

49 ± 38

47 ± 37

0.398

Range

4–189

8–175

n

308

135

Day 2:

Mean ± SD

45 ± 38

46 ± 34

0.949

Range

7–292

6–174

n

287

124

Day 3:

Mean ± SD

45 ± 36

50 ± 38

0.245

Range

7–230

6–242

n

274

118

Day 4:

Mean ± SD

48 ± 39

52 ± 43

0.411

Range

6–264

8–288

n

267

115

Day 5:

Mean ± SD

57 ± 45

55 ± 48

0.706

Range

7–312

7–282

n

261

114

*Standardized values based upon upper limit of normal were used to calculate p-values.

Normal ranges for CARES: ALT 5–40 IU/L male and 5–36 IU/L female. Two different labs were used by RCKC, normal ranges: ALT 0–50 IU/L and 2–60 IU/L male, 2–40 IU/L female.

Kuffner et al. BMC Medicine 2007 5:13   doi:10.1186/1741-7015-5-13