Table 1 |
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|
Baseline characteristics of patients in acetaminophen and placebo groups |
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|
Acetaminophen group (n = 308) |
Placebo group (n = 135) |
p-value* |
|
|
|
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|
Age: |
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|
Mean ± SD |
43 ± 9 |
44 ± 8 |
0.399 |
|
Range |
18–72 |
20–65 |
|
|
Male (%) |
284 (92) |
128 (95) |
0.322 |
|
Ethnic Origin (%): |
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|
Caucasian |
156 (51) |
68 (50) |
0.830 |
|
Hispanic |
45 (15) |
22 (16) |
|
|
African Descent |
49 (16) |
16 (12) |
|
|
Native American |
43 (14) |
23 (17) |
|
|
Other |
15 (5) |
6 (4) |
|
|
Body Mass Index: |
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|
Mean ± SD |
25 ± 5 |
25 ± 4 |
|
|
Range |
15–55 |
17–39 |
|
|
Breath alcohol level at presentation to detoxification site: |
0.711 |
||
|
Mean ± SD |
0.161 ± 0.093 |
0.157 ± 0.099 |
|
|
Range |
0.001–0.710 |
0.001–0.550 |
|
|
Self-reported alcoholic (%) |
301 (98) |
133 (99) |
0.729 |
|
Duration of most recent drinking binge: |
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|
< 1 week |
56 (18) |
22 (16) |
0.193 |
|
1–4 weeks |
98 (32) |
36 (27) |
|
|
> 1 month |
154 (50) |
76 (56) |
|
|
Not reported |
0 (0) |
1 (1) |
|
|
CAGE (no. of yes answers; mean ± SD) |
3.3 ± 0.9 |
3.3 ± 0.9 |
0.645 |
|
Alanine aminotransferase: |
|||
|
mg/dL |
49 ± 38 |
47 ± 37 |
0.398 |
|
Range |
4–189 |
8–175 |
|
|
Aspartate aminotransferase: |
|||
|
IU/L |
55 ± 39 |
55 ± 38 |
0.650 |
|
Range |
6–198 |
12–194 |
|
|
International normalized ratio: |
0.652 |
||
|
INR |
0.96 ± 0.09 |
0.96 ± 0.09 |
|
|
Range |
0.79–1.40 |
0.80–1.30 |
|
|
Albumin: |
0.589 |
||
|
g/dl |
3.94 ± 0.45 |
3.93 ± 0.37 |
|
|
Range |
2.1–4.8 |
2.8–4.0 |
|
|
Total bilirubin: |
|||
|
mg/dL |
0.74 ± 0.53 |
0.68 ± 0.45 |
0.286 |
|
Range |
0.1–4.1 |
0.1–2.8 |
|
|
Gamma glutamyl transferase: |
|||
|
IU/L |
161 ± 308 |
168 ± 274 |
0.799 |
|
Range |
9.0–3492 |
12.0–1893 |
|
|
|
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|
*Standardized values based upon upper limit of normal were used to calculate p-values. Normal ranges for Denver and Seattle sites are as follows. Alanine aminotransferase: Denver, ALT 5–40 mg/dL male, 5–36 mg/dL female; Seattle, 0–50 IU/L and 2–60 IU/L male, 2–40 IU/L female. Aspartate aminotransferases: Denver, 9–36 IU/L; Seattle: 0–50 IU/L and 2–50 IU/L male, 2–35 IU/L female (both). International normalized ratio: Denver, 0.82–1.17; Seattle, 0.9–1.1. Total bilirubin: Denver, 0.2–1.2 mg/dL; Seattle: 0.1–1.2 mg/dL and 0.2–1.5 mg/dL male, 0.2–1.3 mg/dl female. Gamma glutamyl transferase: Denver, 6–50 IU/L; Seattle: 5–105 IU/L male, 2–98 IU/L female and 2–80 IU/L male, 2–60 IU/L female. Albumin: Denver, 3.4–5.5 g/dl; Seattle, 3.3–5.0 and 3.5–4.9 g/dl |
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|
Kuffner et al. BMC Medicine 2007 5:13 doi:10.1186/1741-7015-5-13 |
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