Table 1

Baseline characteristics of patients in acetaminophen and placebo groups

Acetaminophen group (n = 308)

Placebo group (n = 135)

p-value*


Age:

Mean ± SD

43 ± 9

44 ± 8

0.399

Range

18–72

20–65

Male (%)

284 (92)

128 (95)

0.322

Ethnic Origin (%):

Caucasian

156 (51)

68 (50)

0.830

Hispanic

45 (15)

22 (16)

African Descent

49 (16)

16 (12)

Native American

43 (14)

23 (17)

Other

15 (5)

6 (4)

Body Mass Index:

Mean ± SD

25 ± 5

25 ± 4

Range

15–55

17–39

Breath alcohol level at presentation to detoxification site:

0.711

Mean ± SD

0.161 ± 0.093

0.157 ± 0.099

Range

0.001–0.710

0.001–0.550

Self-reported alcoholic (%)

301 (98)

133 (99)

0.729

Duration of most recent drinking binge:

< 1 week

56 (18)

22 (16)

0.193

1–4 weeks

98 (32)

36 (27)

> 1 month

154 (50)

76 (56)

Not reported

0 (0)

1 (1)

CAGE (no. of yes answers; mean ± SD)

3.3 ± 0.9

3.3 ± 0.9

0.645

Alanine aminotransferase:

mg/dL

49 ± 38

47 ± 37

0.398

Range

4–189

8–175

Aspartate aminotransferase:

IU/L

55 ± 39

55 ± 38

0.650

Range

6–198

12–194

International normalized ratio:

0.652

INR

0.96 ± 0.09

0.96 ± 0.09

Range

0.79–1.40

0.80–1.30

Albumin:

0.589

g/dl

3.94 ± 0.45

3.93 ± 0.37

Range

2.1–4.8

2.8–4.0

Total bilirubin:

mg/dL

0.74 ± 0.53

0.68 ± 0.45

0.286

Range

0.1–4.1

0.1–2.8

Gamma glutamyl transferase:

IU/L

161 ± 308

168 ± 274

0.799

Range

9.0–3492

12.0–1893


*Standardized values based upon upper limit of normal were used to calculate p-values.

Normal ranges for Denver and Seattle sites are as follows. Alanine aminotransferase: Denver, ALT 5–40 mg/dL male, 5–36 mg/dL female; Seattle, 0–50 IU/L and 2–60 IU/L male, 2–40 IU/L female. Aspartate aminotransferases: Denver, 9–36 IU/L; Seattle: 0–50 IU/L and 2–50 IU/L male, 2–35 IU/L female (both). International normalized ratio: Denver, 0.82–1.17; Seattle, 0.9–1.1. Total bilirubin: Denver, 0.2–1.2 mg/dL; Seattle: 0.1–1.2 mg/dL and 0.2–1.5 mg/dL male, 0.2–1.3 mg/dl female. Gamma glutamyl transferase: Denver, 6–50 IU/L; Seattle: 5–105 IU/L male, 2–98 IU/L female and 2–80 IU/L male, 2–60 IU/L female. Albumin: Denver, 3.4–5.5 g/dl; Seattle, 3.3–5.0 and 3.5–4.9 g/dl

Kuffner et al. BMC Medicine 2007 5:13   doi:10.1186/1741-7015-5-13

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