Table 4

Histopathology

Patient no., sex, age

Organ

Fibrosis*

Lymphoplasmacytic infiltrate†

Lymphoid follicles

Venulitis

Eosinophilic component

IgG4-positive plasma cells‡

(1) Male, 52

Kidney

+++

+++

Yes

No

No

3

Liver

++

+

No

No

Yes

0

(2) Male, 73

Retroperitoneum

+++

+++

Yes

Yes

Yes

3

(3) Male, 39

Omentum

+

++

Yes

No

No

3

(4) Male, 53

Retroperitoneum

+++

+++

Yes

Yes

Yes

3

(5) Male, 45

Periureter

+++

+++

Yes

Yes

No

2

(6) Female, 58

Retroperitoneum

+++

+++

No

Yes

No

3

(7) Female, 55

Para-aortic tissue

+++

+++

Yes

Yes

No

3

(8) Male, 47

Periureter tissue

+++

+

Yes

Yes

No

2

(9) Male, 48

Retroperitoneum

+++

++

No

No

No

2

(10) Male, 73

Retroperitoneum

+++

+++

Yes

Yes

Yes

1

(11) Female, 56

Retroperitoneum

+++

++

Yes

No

No

1

(12) Male, 53

Liver

++

+

No

No

No

1

Colon

++

+

No

No

No

0

*Degree of interstitial fibrosis: +, mild; ++, moderate; +++, severe fibrosis.

†Degree of inflammation: +++ (severe), >100 inflammatory cells/HPF; ++ (moderate), 30–100 cells/HPF; + (mild), 10–30 cells/HPF

‡IgG4-positive plasma cells: 0, no IgG4 plasma cells/high power field (HPF); 1, ≤ 20 cells/HPF), 2, 20–50 cells/HPF; 3, ≥ 50 cells/HPF (criteria of Aoki et al [12]).

Neild et al. BMC Medicine 2006 4:23   doi:10.1186/1741-7015-4-23