|
Effect of simvastatin allocation on vascular and non-vascular causes of death |
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| Cause of death |
Simvastatin-allocated (10,269) |
Placebo- allocated (10,267) |
Death rate ratio (& 95% CI) |
P-value |
|
|
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| Coronary |
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| Acute MI |
141 (1.4%) |
191 (1.9%) |
0.73 (0.59 – 0.91) |
|
| Sudden death |
147 (1.4%) |
154 (1.5%) |
0.95 (0.75 – 1.19) |
|
| Heart failure* |
65 (0.6%) |
78 (0.8%) |
0.82 (0.59 – 1.15) |
|
| Other coronary |
234 (2.3%) |
284 (2.8%) |
0.82 (0.69 – 0.97) |
|
| Subtotal: Coronary |
587 (5.7%) |
707 (6.9%) |
0.82 (0.74 – 0.92) |
0.0005 |
| Stroke |
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| Haemorrhagic |
23 (0.2%) |
24 (0.2%) |
0.95 (0.54 – 1.68) |
|
| Ischaemic (or unknown) |
73 (0.7%) |
95 (0.9%) |
0.76 (0.56 – 1.03) |
|
| Subtotal: Stroke |
96 (0.9%) |
119 (1.2%) |
0.80 (0.61 – 1.05) |
0.1 |
| Other vascular |
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| Peripheral vascular |
58 (0.6%) |
63 (0.6%) |
0.91 (0.64 – 1.30) |
|
| Other cardiac* |
40 (0.4%) |
48 (0.5%) |
0.83 (0.54 – 1.25) |
|
| Subtotal: Other vascular |
98 (1.0%) |
111 (1.1%) |
0.88 (0.67 – 1.15) |
0.3 |
| VASCULAR |
781 (7.6%) |
937 (9.1%) |
0.83 (0.75 – 0.91) |
<0.0001 |
| Neoplastic |
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| Respiratory |
127 (1.2%) |
133 (1.3%) |
0.94 (0.74 – 1.20) |
|
| Gastrointestinal |
112 (1.1%) |
103 (1.0%) |
1.08 (0.82 – 1.41) |
|
| Genitourinary |
47 (0.5%) |
46 (0.4%) |
1.01 (0.67 – 1.52) |
|
| All others |
73 (0.7%) |
62 (0.6%) |
1.17 (0.83 – 1.63) |
|
| Subtotal: Neoplastic |
359 (3.5%) |
345 (3.4%) |
1.03 (0.89 – 1.19) |
0.7 |
| Other non-vascular |
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| Respiratory |
90 (0.9%) |
114 (1.1%) |
0.78 (0.59 – 1.03) |
|
| Gastrointestinal |
35 (0.3%) |
41 (0.4%) |
0.85 (0.54 – 1.33) |
|
| Other medical† |
47 (0.5%) |
49 (0.5%) |
0.95 (0.64 – 1.42) |
|
| Non-medical |
16 (0.2%) |
21 (0.2%) |
0.75 (0.40 – 1.44) |
|
| NON-VASCULAR |
547 (5.3%) |
570 (5.6%) |
0.95 (0.85 – 1.07) |
0.4 |
| ALL DEATHS |
1328 (12.9%) |
1507 (14.7%) |
0.87 (0.81 – 0.94) |
0.0003 |
|
* Heart failure deaths were subdivided into those considered to be due to coronary disease and those (5 versus 8) due to other vascular (or unknown) causes. † Includes renal, infectious, metabolic, neurological and unknown deaths. | ||||
Heart Protection Study Collaborative Group BMC Medicine 2005 3:6 doi:10.1186/1741-7015-3-6 |
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