Table 2

Reasons for discontinuation by study

Reason for Discontinuation n (%)

Study 1 (n = 339)

Study 2 (n = 346)

Study 3 (n = 548)

Study 4 (n = 394)

Total (N = 1627)


Overall Discontinuation

161(47.5)

190(54.9)

268(48.9)

247(62.7)

866(53.2)


Poor Response or Worsening

67(41.6)

78(41.0)

99(36.9)

71(28.7)

315(36.4)

Intolerability to Medication

19(11.8)

16(8.4)

31(11.6)

40(16.2)

106(12.2)

Other Reasons*

75(46.6)

96(50.5)

138(51.5)

136(55.1)

445(51.4)


*Other reasons for discontinuation included criteria not met, lost to follow-up, noncompliance, personal conflict, physician decision, satisfactory response, and sponsor decision.

Liu-Seifert et al. BMC Medicine 2005 3:21   doi:10.1186/1741-7015-3-21

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