|
Reasons for discontinuation by study |
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| Reason for Discontinuation n (%) |
Study 1 (n = 339) |
Study 2 (n = 346) |
Study 3 (n = 548) |
Study 4 (n = 394) |
Total (N = 1627) |
|
|
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| Overall Discontinuation |
161(47.5) |
190(54.9) |
268(48.9) |
247(62.7) |
866(53.2) |
|
|
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| Poor Response or Worsening |
67(41.6) |
78(41.0) |
99(36.9) |
71(28.7) |
315(36.4) |
| Intolerability to Medication |
19(11.8) |
16(8.4) |
31(11.6) |
40(16.2) |
106(12.2) |
| Other Reasons* |
75(46.6) |
96(50.5) |
138(51.5) |
136(55.1) |
445(51.4) |
|
*Other reasons for discontinuation included criteria not met, lost to follow-up, noncompliance, personal conflict, physician decision, satisfactory response, and sponsor decision. | |||||
Liu-Seifert et al. BMC Medicine 2005 3:21 doi:10.1186/1741-7015-3-21 |
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