Chronic Fatigue Syndrome – A clinically empirical approach to its definition and study
BMC Medicine 2005, 3:19 doi:10.1186/1741-7015-3-19
- Source of threshold for Symptom Inventory (SI) criteria
- Who Can Be Diagnosed with CFS?
- Research Study finds 38% of those with a Major Depressive Disorder satisfied these criteria for CFS (i.e. they lack specificity)
- Exclusionary conditions or essential pathology?
- Another CFS study raises questions about the use of the RE subscale in a definition of CFS
- Analyses of 2 separate CFS cohorts found 6 of the 8 SF-36 subscales group together - two that don't are MH and RE (the latter is being used in this definition)
- Using two MFI scales ("General Fatigue" or "Reduced Activity") to ensure patients satisfying the definition have "severe fatigue"
- Why is this definition being referred to as an "empirical definition"?
- This may not be a representative group of those who would be diagnosed in a random sample using the "standardized clinically empirical criteria"
- Data from another population study found scores on the RE subscale are similar in CFS patients to those found in healthy controls
- How many SF-36 subscales were used for the "standardized clinically empirical criteria"?
- MDDm should be resolved for more than 5 years before a CFS diagnosis can be given