Figure 1.

Duration of use of NSAIDs and individual NSAIDs among current users (use within a month) and risk of MI. Overall, current use of tNSAIDs was associated with a RR of 1.07 (95% CI, 0.95–1.21). The corresponding estimates for diclofenac, ibuprofen and naproxen were 1.17 (0.98–1.40), 1.05 (0.86–1.28) and 0.89 (0.64–1.25), respectively. Duration of use was computed adding the periods of "consecutive" prescriptions, defined as an interval of less than one month between the end of supply of one prescription and the date of prescription of the subsequent one. Estimates are adjusted for sex, age, calendar year, anemia, smoking status, alcohol use, diabetes, hypertension, hyperlipidemia, BMI, RA, OA, prior cardiovascular disease, use of steroids, anticoagulants, aspirin, paracetamol, and NSAIDs. The duration response trends for NSAIDs, diclofenac, ibuprofen and naproxen were P = .04, P = .02, P = .47, P = .54 respectively.