Table 2

Model Parameters

Parameter

Stem Cell Niche

Immortal Lineages


Stem Cells per Crypt

4–256

2

Probability of Asymmetric Stem Cell Division (P1)*

0.98 to 0.89

1.0

Probability of Symmetric Stem Cell Division: zero (P0) or two (P2) stem cell offspring*

0.02 to 0.11

0

Methylation Error Rate

2 × 10-5 per CpG site per division**

2 × 10-5 per CpG site per division**

Stem Cell Division Rate

0.75 per day

0.75 per day


*P0+P1+P2 = 1, with P0 = P2

** Equal probabilities for methylation and demethylation errors

Kim et al. BMC Medicine 2005 3:10   doi:10.1186/1741-7015-3-10

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