|
Model Parameters |
||
| Parameter |
Stem Cell Niche |
Immortal Lineages |
|
|
||
| Stem Cells per Crypt |
4–256 |
2 |
| Probability of Asymmetric Stem Cell Division (P1)* |
0.98 to 0.89 |
1.0 |
| Probability of Symmetric Stem Cell Division: zero (P0) or two (P2) stem cell offspring* |
0.02 to 0.11 |
0 |
| Methylation Error Rate |
2 × 10-5 per CpG site per division** |
2 × 10-5 per CpG site per division** |
| Stem Cell Division Rate |
0.75 per day |
0.75 per day |
|
*P0+P1+P2 = 1, with P0 = P2 ** Equal probabilities for methylation and demethylation errors | ||
Kim et al. BMC Medicine 2005 3:10 doi:10.1186/1741-7015-3-10 |
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