Table 2 |
|||
|
Comparison of 50% antiviral and cell division inhibitory concentrations (IC50) and selectivity (viral versus cellular IC50) of selected antiviral drugs and THC |
|||
|
Inhibitor compound |
KSHV IC50 (μM) |
Cellular IC50 (μM) |
Selectivity index (viral versus cellular IC50) |
|
|
|||
|
Acyclovir |
75 [ref. 32] |
Not done |
|
|
Ganciclovir |
5.1 [ref. 32] |
Not done |
|
|
Foscarnet |
97 [ref. 32] |
Not done |
|
|
Cidofovir |
0.05 [ref. 32] |
Not done |
|
|
THC |
3.3 (this work) |
33 (this work) |
10 (this work) |
|
MHV 68 IC50 (μM) |
|||
|
Acyclovir |
6 [ref. 34] 100 [ref. 33] |
182 [ref. 34] |
30 [ref. 34] |
|
Ganciclovir |
28 [ref. 34] |
108 [ref. 34] |
3.7 [ref. 34] |
|
Foscarnet |
120 [ref. 34] |
1413 [ref. 34] |
11 [ref. 34] |
|
Cidofovir |
0.08 [ref. 34] |
78 [ref. 34] |
10,000 [ref. 34] |
|
THC |
1.9 (this work) |
99 (this work) |
52 (this work) |
|
|
|||
|
Medveczky et al. BMC Medicine 2004 2:34 doi:10.1186/1741-7015-2-34 |
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