Table 4

HR (95% CI) and estimated loss of RLE (95% CI) for body weight status, after exclusion of early deaths, and after stratification by smoking status, the EPIC-Heidelberg cohorta
Men Women
Multivariable HR (95% CI)        Loss of RLE (95% CI) Multivariable HR (95% CI) Loss of RLE (95% CI)
Early deathsb excluded
Body weight status
Optimal BMI 1.00 0 1.00 0
Low BMI 1.51 (1.15, 1.98) 3.0 (1.0, 4.6) 1.30 (1.00, 1.69) 1.8 (0.3, 3.1)
Overweight 1.14 (0.95, 1.37) 1.0 (0, 2.0) 1.02 (0.79, 1.30) 0.1 (−1.1, 1.7)c
Obesity 1.49 (1.21, 1.84) 2.9 (1.8, 4.1) 1.48 (1.13, 1.93) 2.6 (1.2, 4.3)
Stratified by smoking status
Never smokers
Optimal BMI 1.00 0 1.00 0
Low BMI 1.50 (0.80, 2.82) 2.9 (−2.5, 6.4)c 1.05 (0.71, 1.55) 0.4 (−2.4, 2.8)c
Overweight 1.15 (0.77, 1.72) 1.0 (−1.5, 3.7)c 0.97 (0.69, 1.36) −0.2 (−2.0, 2.1)c
Obesity 2.05 (1.31, 3.21) 5.2 (2.1, 8.6) 1.53 (1.06, 2.19) 3.0 (0.9, 5.2)
Former smokers
Optimal BMI 100 0 1.00 0
Low BMI 1.32 (0.77, 2.29) 2.0 (−1.6, 5.4)c 1.14 (0.63, 2.08) 0.9 (−3.1, 4.4)c
Overweight 1.36 (1.01, 1.83) 2.2 (0.6, 4.4) 1.41 (0.86, 2.32) 2.3 (−0.6, 5.2)c
Obesity 1.55 (1.10, 2.18) 3.1 (1.2, 5.4) 1.37 (0.75, 2.48) 2.1 (−1.1, 5.6)c
Current smokers
Optimal BMI 1.00 0 1.00 0
Low BMI 1.70 (1.21, 2.40) 4.3 (1.7, 6.6) 1.83 (1.19, 2.82) 4.8 (2.1, 8.0)
Overweight 1.00 (0.77, 1.31) 0 (−1.9, 2.0)c 1.04 (0.66, 1.63) 0.3 (−2.6, 3.4)c
Obesity 1.39 (1.00,1.92) 2.7 (0.6, 5.2) 1.68 (1.01, 2.80) 4.2 (0.6, 7.6)

aParticipants with pre-existing diabetes, cardiovascular disease or cancer were excluded. bDeaths occurred in the first two years of the follow-up period (nmen = 48; nwomen = 33). cMinus sign denotes a gain in RLE. BMI, body mass index; CI, confidence interval; EPIC, European Prospective Investigation into Cancer and Nutrition; HR, hazard ratio; RLE, residual life expectancy.

Li et al.

Li et al. BMC Medicine 2014 12:59   doi:10.1186/1741-7015-12-59

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