Open Access Research article

Local versus general anesthesia for transcatheter aortic valve implantation (TAVR) – systematic review and meta-analysis

Georg M Fröhlich1, Alexandra J Lansky2, John Webb3, Marco Roffi4, Stefan Toggweiler5, Markus Reinthaler1, Duolao Wang6, Nevil Hutchinson7, Olaf Wendler8, David Hildick-Smith9 and Pascal Meier12*

Author Affiliations

1 The Heart Hospital, University College London Hospitals, London, UK

2 Division of Cardiology, Yale Medical School, New Haven, CT, USA

3 Department of Cardiology, St. Paul’s Hospital, University of British Columbia, Vancouver, BC, Canada

4 Department of Cardiology, University Hospital Geneva HUGE, Geneva, Switzerland

5 Department of Cardiology, Kantonsspital Luzern, Lucerne, Switzerland

6 Department of Medical Statistics, London School of Hygiene and Tropical Medicine London, London, UK

7 Division of Anesthesiology, Brighton and Sussex University Hospital, Brighton, UK

8 Department of Cardiothoracic Surgery, King’s College Hospital, London, UK

9 Division of Cardiology, Brighton and Sussex University Hospital, Brighton, UK

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BMC Medicine 2014, 12:41  doi:10.1186/1741-7015-12-41

Published: 10 March 2014

Additional files

Additional file 1:

Checklist of preferred reporting items for systematic reviews and meta-analyses (PRISMA).

Format: DOC Size: 64KB Download file

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Additional file 2:

Search syntax for Medline.

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Additional file 3:

Endpoint definitions of the included studies.

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Additional file 4:

Valve types used in the individual studies.

Format: DOCX Size: 11KB Download file

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Additional file 5:

Decision-making process in individual studies regarding use of general or local anesthesia.

Format: DOCX Size: 12KB Download file

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Additional file 6:

Forest plot of risk ratios for 30-day cardiac and procedure-related mortality. CI: confidence interval.

Format: TIFF Size: 34KB Download file

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Additional file 7:

Reasons for the conversion from local to general anesthesia.

Format: DOCX Size: 11KB Download file

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Additional file 8:

Forest plot of risk ratios (RR) for vascular complications. CI: confidence interval.

Format: TIFF Size: 31KB Download file

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Additional file 9:

Forest plot of risk ratios for procedural success. CI: confidence interval.

Format: TIFF Size: 36KB Download file

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Additional file 10:

Forest plot of risk ratios for myocardial infarction CI: confidence interval.

Format: TIFF Size: 39KB Download file

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Additional file 11:

Forest plot of risk ratios for acute kidney injury CI: confidence interval.

Format: TIFF Size: 35KB Download file

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Additional file 12:

Forest plot of risk ratios for sepsis. CI: confidence interval.

Format: TIFF Size: 31KB Download file

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