Table 1

Patient characteristics
Characteristic BD + HDM/SCT (number = 28) HDM/SCT (number = 28) P value
Age (years)
 Median 53 51.5 0.23
Range 38-65 37-63
Male/female (number) 18/10 16/12 0.78
Organ involvement, number (%)
 Kidney 28 (100) 28 (100) 1.0
 Heart 17 (60.7) 15 (53.5) 0.79
 Liver 1 (3.6) 3 (10.7) 0.61
 Nervous system 3 (10.7) 2 (7.1) 1.0
>1 organ involved 17 (60.7) 16 (57.1) 1.0
Cardiac stage, number (%)a
 I 14 (50) 12 (42.9) 0.86
 II 10 (35.7) 11 (39.3)
 III 4 (14.3) 5 (17.8)
Involved FLC, number (%)
 κ 3 (10.7) 2 (7.1) 1.0
 λ 25 (89.3) 26 (92.9)
Abnormal FLC κ-to-λ ratio number (%) 26 (92.9) 27 (96.4) 1.0
ECOG PS (0/1/2), number (%)
 0 13 (44.4) 14 (46.2) 0.75
 1 10 (37) 11 (42.3)
 2 5 (18.6) 3 (11.5)
24-hour urine protein (g/24 hour) 4.6 ± 2.2 5.8 ± 4.1 0.18
Albumin (g/L) 26.8 ± 6.1 25.7 ± 4.9 0.44
Creatinine (mg/dL) 0.8 ± 0.3 0.8 ± 0.4 0.72
GFR (mL/min) 89.0 ± 19.6 85.1 ± 25.6 0.53
Marrow plasma cells (%) 3.2 ± 2.7 2.8 ± 2.1 0.59
Echocardiogram septal thickness (mm) 11.7 ± 2.4 11.1 ± 1.8 0.33
Ejection fraction (%) 60.8 ± 6.5 62.7 ± 6.1 0.27
Alkaline phosphatasea (U/L)
 Median 58 49 0.11
 Range 23 to 321 33 to 661
NT-proBNP (ng/L)
 Median 268 249 0.32
 Range 55.5 to 13,730 15.2 to 7,709
 >8500 ng/L (%) 1 (3.6) 1 (3.6)
BNP (ng/L)
 Median 117 120 0.85
 Range 22 to 3,261 17 to 3,078
Troponin-I (ng/ml)
 Median 0.003 0.003 0.83
 Range 0 to 0.15 0 to 0.12
iFLC (mg/L)
 Median 114.9 97.8 0.15
 Range 25 to 516 24 to 204
dFLC (mg/L)
 Median 96.1 64.8 0,12
 Range 14 to 471 14 to 163
 >180 mg/L (%) 2 (7.1) 0

aThe upper reference limit for alkaline phosphatase is 172 U/L. BNP, brain natriuretic peptide; ECOG PS, Eastern Cooperative Oncology Group performance status; FLC, free light chain; GFR, glomerular filtration rate.

Huang et al.

Huang et al. BMC Medicine 2014 12:2   doi:10.1186/1741-7015-12-2

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