Open Access Highly Accessed Research article

Urinary metabolic profiles in early pregnancy are associated with preterm birth and fetal growth restriction in the Rhea mother–child cohort study

Léa Maitre145, Eleni Fthenou23, Toby Athersuch14, Muireann Coen14, Mireille B Toledano45, Elaine Holmes14, Manolis Kogevinas3678, Leda Chatzi2* and Hector C Keun14*

Author Affiliations

1 Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK

2 Department of Social Medicine, Faculty of Medicine, University of Crete, PO Box 2208, 71003 Heraklion, Greece

3 Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain

4 MRC-PHE Centre for Environment and Health, Imperial College London, London W2 1PG, UK

5 Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London W2 1PG, UK

6 National School of Public Health, Alexandras Avenue 196, 115 21 Athens, Greece

7 IMIM (Hospital del Mar Research Institute), Barcelona, Spain

8 CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain

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BMC Medicine 2014, 12:110  doi:10.1186/1741-7015-12-110

Published: 11 July 2014

Additional files

Additional file 1:

Analysis of median differences (Mann-Whitney U test) for all metabolite integrals comparing negative birth outcome groups and controls.

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Additional file 2:

Discrimination between birth outcome cases and control group receiver operating characteristic (ROC) curves for selected candidate metabolites.

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