Table 5

Oxford Record Linkage Study (ORLS) (1963 to 1998)a: rate ratios for tuberculosis (TB) in people with immune-mediated disease (IMD) and for immune-mediated disease in people with tuberculosis
Exposure (earlier admission) Outcome (later admission) Observed Expected Rate ratio (95% CI) P value
Addison's disease Tuberculosis 15 0.8 20.06 (11.18 to 33.27) <0.001
Ankylosing spondylitis Tuberculosis 6 1.6 3.87 (1.42 to 8.46) 0.002
Chronic active hepatitis Tuberculosis 4 0.3 12.32 (3.35 to 31.66) <0.001
Crohn's disease Tuberculosis 18 4 4.61 (2.72 to 7.33) <0.001
Pernicious anemia Tuberculosis 25 11.1 2.28 (1.47 to 3.39) <0.001
Rheumatoid arthritis Tuberculosis 69 26.7 2.71 (2.09 to 3.46) <0.001
SLEb Tuberculosis 8 0.5 17.29 (7.44 to 34.22) <0.001
Tuberculosis Addison's diseaseb 13 1.9 7.6 (3.94 to 13.48) <0.001
Tuberculosis Chronic active hepatitisc 6 1.2 5.37 (1.93 to 12.07) <0.001
Tuberculosis Goodpasture's syndromeb 2 0.3 8.09 (0.91 to 34.08) 0.018
Tuberculosis Myxedemab 36 23.1 1.57 (1.1 to 2.18) 0.009
Tuberculosis SLEb 7 1.4 5.31 (2.1 to 11.21) <0.001
Tuberculosis Dermatomyositisb 3 0.4 8.18 (1.6 to 26.15) 0.001

The table shows observed numbers of cases of TB in people with selected immune-mediated diseases, and observed numbers of cases of selected immune-mediated diseases in people with TB; expected number of cases, rate ratios and 95% confidence intervals (CIs) based on comparison with the control cohort for statistically significant comparisons. aYears 1963 to 1998 unless otherwise stated (span of years depends on whether the disease is separately identifiable in earlier editions of the International Classification of Diseases (ICD)). bCases identified from 1968 to 1998 (that is, from ICD-8 onwards). cCases identified from 1979 to 1998 (that is, from ICD-9 onwards.

Ramagopalan et al.

Ramagopalan et al. BMC Medicine 2013 11:97   doi:10.1186/1741-7015-11-97

Open Data