Changes in activated microglia in factor V Leiden antiphospholipid syndrome (FVL-APS) mice seen by Iba1 immunoreactivity. Representative images stained with (A–C) Iba1, (D–F) DAPI. (G–I) Double-stained pictures were merged. (J,K) Iba1 immunoreactivity measurements (expressed as area/mm2) showed (J) a significant increase in the FVLQ/+-APS group compared with the FVL adjuvant-immunized control and FVLQ/Q-APS groups (P < 0.001), (K) and a significant decrease in the FVLQ/Q-APS group compared with the FVLQ/+-APS and the FVL-control groups (P < 0.01).
Katzav et al. BMC Medicine 2013 11:92 doi:10.1186/1741-7015-11-92