Table 2

Selected genes associated with various SSc disease manifestations based on case- case comparisons.

Gene

Clinical Association


CTGF

ILD by pulmonary function test or HRCT [27]

HGF

End-stage ILD by pulmonary function test [28]

HLA-DRB1*04:07

Scleroderma Renal Crisis [38]

HLA-DRB1*13:04

Scleroderma Renal Crisis [38]

IL23R

PAH by echocardiogram or right heart catheterization [33]

IRAK1

ILD by HRCT [29]

IRF5

Overall survival [26]

ILD by HRCT [6,30]

Severity of ILD by pulmonary function test [26]

KCNA5

PAH by right heart catheterization [34]

MMP-12

ILD by pulmonary function test and HRCT [31]

SP-B

ILD by HRCT [32]

TLR2

PAH by right heart catheterization [35]

TNFAIP3

PAH by right heart catheterization [36]

UPAR

PAH by right heart catheterization [37]


Assassi et al. BMC Medicine 2013 11:9   doi:10.1186/1741-7015-11-9

Open Data