Table 2 |
|
|
Selected genes associated with various SSc disease manifestations based on case- case comparisons. |
|
|
Gene |
Clinical Association |
|
|
|
|
CTGF |
ILD by pulmonary function test or HRCT [27] |
|
HGF |
End-stage ILD by pulmonary function test [28] |
|
HLA-DRB1*04:07 |
Scleroderma Renal Crisis [38] |
|
HLA-DRB1*13:04 |
Scleroderma Renal Crisis [38] |
|
IL23R |
PAH by echocardiogram or right heart catheterization [33] |
|
IRAK1 |
ILD by HRCT [29] |
|
IRF5 |
Overall survival [26] Severity of ILD by pulmonary function test [26] |
|
KCNA5 |
PAH by right heart catheterization [34] |
|
MMP-12 |
ILD by pulmonary function test and HRCT [31] |
|
SP-B |
ILD by HRCT [32] |
|
TLR2 |
PAH by right heart catheterization [35] |
|
TNFAIP3 |
PAH by right heart catheterization [36] |
|
UPAR |
PAH by right heart catheterization [37] |
|
|
|
|
Assassi et al. BMC Medicine 2013 11:9 doi:10.1186/1741-7015-11-9 |
|
