Table 4

Aggregation of ADs.

Disease in probands


T1D

AITD

SLE

RA

MS


AD in FDRs

USA [35]

UK [36]

Colombia [37]

Spain [38]

Swed/Lith [40]

UK [33]

USA [35]

USA [35]

Latin America [42]

NL [44]

USA 1 [35]

USA 2 [45]

UK [46]

USA 3 [48]

USA1 [32]

USA 2 [35]

USA 3 [87]

Greece (Multiplex) [50]

Greece (Simplex) [50]

Australia [52]

Italy (Multiplex) [53]

Italy (Simplex) [53]

Canada [54]


AITD

11.11

0.98

2.4

4.6

0.88

21.7

16

20

14.7

3.9

4.81

5.50

13,28

Hyperthyroidisma

4.2

3.75

22.1

9.42

8.2

14.15

Hypothyroidism a

7.38

1.71

0.74

9.43

T1D

13.5

7.53

78.9

39.7

12.53

30.9

14.49

74

93.2

14.41

5.41

49.65

11.70

3.51

1.93

RA

0.9

7.41

22.5

16.98

64

28.57

2.0

7.8

18.7

0.68

0.18

20.75

1.73

PA

2.14

12.38

SLE

462

13.35

5.71

312.5

595

163.4

390

225

42.8

25

471

AdD

4.81

CD

3.6

0.54

0.39

VIT

0.8

2.75

1.6

0.86

0.09

4.72

MS

7.61

86.2

130

164

67.6

MG

9.13

9.17

68.49

7.09

IBD

0.89

1.25

30

4.2

21.79

4.44

24

10.9

7.38

15.09

PSO

14.8

1.6

10

15.69

2.67

25

5.48

1.77

33.9

SS

7.9

6.85

1.77

AS

2.29

56.6

SSc

500

595

471

IIM

400


Table shows aggregation (λ) of ADs. The top row depicts the AD present in the proband while the first column shows the AD present in FDRs. The numbers correspond to the calculation of aggregation. aOnly autoimmune hypothyroidism and hyperthyroidism are depicted. Prevalences in the general population according to [2,29-32]. If a range was reported the mean was calculated. AdD, Addison's disease; AS, ankylosing spondylitis; AITD, autoimmune thyroid disease; CD, celiac disease; IBD, inflammatory bowel disease; IIM, idiopathic inflammatory myositis; Lith, Lithuania; MG, myasthenia gravis; MS, multiple sclerosis; NL, The Netherlands; PA, pernicious anemia; PSO, psoriasis; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; SS, Sjögren's syndrome; SSc, systemic sclerosis; Swed, Sweden; T1D, type 1 diabetes; VIT, vitiligo.

Cárdenas-Roldán et al. BMC Medicine 2013 11:73   doi:10.1186/1741-7015-11-73

Open Data