Patient flow. 1Inclusion criteria: Children aged >60 days and <12 years with severe febrile illness including impaired consciousness (prostration or coma) and/or respiratory distress (increased work of breathing) were screened for clinical evidence of impaired perfusion (shock) to be eligible for the trial. Impaired perfusion was defined as any one of the following: CRT 3 or more secs, lower limb temperature gradient, a weak radial pulse volume or severe tachycardia: (<12 months: >180 beats per minute (bpm); 12 months to 5 years: >160bpm; >5 years: >140 bpm). 2Exclusion criteria: Evidence of severe acute malnutrition (visible severe wasting or kwashiorkor); gastroenteritis; chronic renal failure, pulmonary edema or other conditions in which volume expansion is contraindicated; non-infectious causes of severe illness (68); if they already received an isotonic volume resuscitation. 3Other reasons for exclusion: child unable to return for follow-up (111), enrolled in a different study (65), no trial packs/fluid or blood (47), previously enrolled to FEAST (17), died (11), other (181), missing reason (26). 4Severe hypotension defined as systolic blood pressure <50mmHg if <12m; <60mmHg if 1-5years; <70mmHg if >5years- eligible children with severe hypotension were enrolled into FEAST B (see text) 5Child was not febrile (had no fever or history of fever). 6One child had severe hypotension and one child did not have impaired perfusion.
Maitland et al. BMC Medicine 2013 11:68 doi:10.1186/1741-7015-11-68