Open Access Open Badges Research article

Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial

Kathryn Maitland12*, Elizabeth C George3, Jennifer A Evans4, Sarah Kiguli5, Peter Olupot-Olupot6, Samuel O Akech2, Robert O Opoka5, Charles Engoru7, Richard Nyeko8, George Mtove9, Hugh Reyburn109, Bernadette Brent12, Julius Nteziyaremye6, Ayub Mpoya2, Natalie Prevatt1, Cornelius M Dambisya6, Daniel Semakula5, Ahmed Ddungu5, Vicent Okuuny7, Ronald Wokulira7, Molline Timbwa2, Benedict Otii8, Michael Levin1, Jane Crawley3, Abdel G Babiker3, Diana M Gibb3 and for the FEAST trial group

Author Affiliations

1 Wellcome Trust Centre for Clinical Tropical Medicine, Department of Paediatrics, Faculty of Medicine, St Marys Campus, Norfolk Place, Imperial College, London W2 1PG, UK

2 Kilifi Clinical Trials Facility, KEMRI-Wellcome Trust Research Programme, PO Box 230, Kilifi, Kenya

3 Medical Research Council (MRC) Clinical Trials Unit, Aviation House, 125 Kingsway London, WC2B 6NH, UK

4 Department of Paediatrics University Hospital of Wales Heath Park, Cardiff, CF14 4XW, Wales, UK

5 Department of Paediatrics, Mulago Hospital, PO Box 7070, Makerere University, Kampala, Uganda

6 Department of Paediatrics, Mbale Regional Referral Hospital Pallisa Road Zone, PO Box 921, Mbale, Uganda

7 Department of Paediatrics, Soroti Regional Referral Hospital, PO Box 289, Soroti, Uganda

8 Department of Paediatrics, St Mary's Hospital, PO Box 180, Lacor, Uganda

9 Department of Paediatrics Joint Malaria Programme, Teule Hospital, PO Box 81, Muheza, Tanzania

10 Joint Malaria Programme, PO Box 2228, KCMC, Moshi, Tanzania

For all author emails, please log on.

BMC Medicine 2013, 11:68  doi:10.1186/1741-7015-11-68

See related article:

Published: 14 March 2013

Additional files

Additional file 1:

Figure S1: Box and whisker plots and bar charts of bedside vital status observations, oxygen saturation and hypoglycemia by arm (fluid arms combined) versus control arm. Table S1: Admission presentation syndromes by randomization arm (FEAST A only). Figure S2 : Hazard ratios and 95% confidence intervals of boluses compared to no bolus for mortality over different levels of oxygen saturation at baseline. Figure S3: Hazard ratios and 95% confidence intervals for boluses compared to no bolus for mortality over different levels of hemoglobin at baseline. Table S2: Terminal clinical events for 297 children that died within 48 hours by baseline presentation. Figure S4a: Cumulative incidence for bolus and no-bolus arms by cardiogenic only, neurological only or respiratory only terminal clinical events. Figure S4b: Cumulative incidence by bolus versus no bolus for combined causes: respiratory and neurological, cardiogenic and neurological, and unknown or other terminal clinical events. Table S3a: Terminal clinical event by 48 hours by randomization arm (bolus versus no bolus) and by whether they were enrolled before or after the protocol amendment. Table S3b: Terminal clinical event by 48 hours by randomization arm (bolus versus no bolus) by malaria status. Table S3c: Terminal clinical events in those with anemia and those without anemia at baseline. Percentages are out of all those enrolled in that arm within the anemia group or non-anemia group (totals are at the top of each column). Table S4a: Mortality at 48 hours with and without persisting features of shock at one hour. Table S4b: Mortality at 48 hours in those with or without hypoxia at baseline.

Format: DOC Size: 476KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data