Table 5

Association of reversible metabolites with smoking status change in the prospective dataset (KORA S4 → F4)

β estimate of smoking status

(95% confidence interval)

P


Men

Arginine

-0.12 (-0.18, -0.06)

1.4e-04a

Ornithine

-0.16 (-0.24, -0.08)

2.1e-04a

PC aa C34:1

-0.09 (-0.15, -0.03)

3.3e-03a

PC aa C36:0

0.17 (0.09, 0.25)

6.4e-05a

PC aa C36:1

-0.12 (-0.18, -0.05)

8.5e-04a

PC aa C38:0

0.14 (0.06, 0.22)

3.0e-04a

PC aa C38:3

-0.04 (-0.11, 0.02)

1.7e-01

PC aa C40:4

-0.11 (-0.18, -0.03)

6.0e-03

PC ae C34:3

0.14 (0.06, 0.21)

3.5e-04a

PC ae C38:0

0.13 (0.05, 0.21)

1.8e-03a

PC ae C38:6

0.11 (0.04, 0.18)

1.5e-03a

PC ae C40:6

0.08 (0.01, 0.15)

2.1e-02

lysoPC a C18:2

0.03 (-0.06, 0.11)

5.2e-01


Women

Carnitine

-0.12 (-0.20, -0.05)

1.4e-03

PC aa C32:1

-0.18 (-0.32, -0.03)

2.1e-03

PC aa C36:1

-0.11 (-0.20, -0.02)

2.0e-02

PC ae C34:3

0.09 (-0.02, 0.19)

0.95

SM (OH) C22.2

0.12 (0.02, 0.22)

1.9e-02


Result of smoking status on metabolite concentrations using linear mixed model for S4 → F4 longitudinal data, adjusted for age, BMI, and alcohol consumption. PC: phosphatidylcholine; aa: diacyl-; ae: acyl-alkyl-; lysoPC: acyl-phosphatidylcholine; SM (OH): hydroxysphingomyeline. a FDR<0.05.

Xu et al. BMC Medicine 2013 11:60   doi:10.1186/1741-7015-11-60

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