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Open Access Research article

Association of fascin-1 with mortality, disease progression and metastasis in carcinomas: a systematic review and meta-analysis

Vanessa Y Tan12, Sarah J Lewis1, Josephine C Adams2* and Richard M Martin1*

Author Affiliations

1 School of Social and Community Medicine, University of Bristol, 39 Whatley Road, Bristol BS8 2PS, UK

2 School of Biochemistry, University of Bristol, Medical Sciences Building, University Walk, Bristol BS8 1TD, UK

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BMC Medicine 2013, 11:52  doi:10.1186/1741-7015-11-52


Please see related commentary article here http://www.biomedcentral.com/1741-7015/11/53

Published: 26 February 2013

Additional files

Additional file 1:

Supplementary data on the data extraction and analysis methods. 1. Search terms used. 2. Newcastle-Ottawa Scale results for studies analysing mortality. 3. Alternative scoring methodologies used to assess immunohistochemical staining of Fascin-1. 4. Method used to derive hazard ratios from the Kaplan-Meier curve analysis.

Format: DOCX Size: 33KB Download file

Open Data

Additional file 2:

Study characteristics and key results of papers included in our meta-analysis. Data were extracted from the indicated publications as described in the Methods. Blank category boxes indicate that this data category was absent from the publication.

Format: DOCX Size: 42KB Download file

Open Data

Additional file 3:

Funnel plot analysis for lymph node metastasis after excluding studies [8,64]. Black dots represent each study's effect estimate (drawn on a log scale) plotted against its standard error. The outer dashed lines represent the 95% confidence limits around the summary effect estimate, within which 95% of studies are expected to lie in the absence of both biases and heterogeneity. P-values are for the results of Egger's test to assess publication bias.

Format: PDF Size: 11KB Download file

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Open Data