Email updates

Keep up to date with the latest news and content from BMC Medicine and BioMed Central.

Journal App

google play app store
Open Access Research article

Association of fascin-1 with mortality, disease progression and metastasis in carcinomas: a systematic review and meta-analysis

Vanessa Y Tan12, Sarah J Lewis1, Josephine C Adams2* and Richard M Martin1*

Author Affiliations

1 School of Social and Community Medicine, University of Bristol, 39 Whatley Road, Bristol BS8 2PS, UK

2 School of Biochemistry, University of Bristol, Medical Sciences Building, University Walk, Bristol BS8 1TD, UK

For all author emails, please log on.

BMC Medicine 2013, 11:52  doi:10.1186/1741-7015-11-52

Please see related commentary article here

Published: 26 February 2013

Additional files

Additional file 1:

Supplementary data on the data extraction and analysis methods. 1. Search terms used. 2. Newcastle-Ottawa Scale results for studies analysing mortality. 3. Alternative scoring methodologies used to assess immunohistochemical staining of Fascin-1. 4. Method used to derive hazard ratios from the Kaplan-Meier curve analysis.

Format: DOCX Size: 33KB Download file

Open Data

Additional file 2:

Study characteristics and key results of papers included in our meta-analysis. Data were extracted from the indicated publications as described in the Methods. Blank category boxes indicate that this data category was absent from the publication.

Format: DOCX Size: 42KB Download file

Open Data

Additional file 3:

Funnel plot analysis for lymph node metastasis after excluding studies [8,64]. Black dots represent each study's effect estimate (drawn on a log scale) plotted against its standard error. The outer dashed lines represent the 95% confidence limits around the summary effect estimate, within which 95% of studies are expected to lie in the absence of both biases and heterogeneity. P-values are for the results of Egger's test to assess publication bias.

Format: PDF Size: 11KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data