Table 1

Methodological quality assessment of the included studies

Study

Clearly stated aim

Inclusion of consecutive patients

Prospective collection of data

Endpoints appropriate to aim of study + ITT

Unbiased assessment of study endpoint(s)

Follow-up period appropriate to aim of study

Loss to follow-up <5%

Prospective calculation of study size

Adequate control group

Con-temporary groups

Baseline equivalence of groups

Adequate statistical analyses

Randomizationa

Total score


[19]

2

2

2

2

0

2

2

2

2

2

2

2

0

22

[20]

2

2

2

1

2

2

1

0

2

2

1

2

0

19

[21]

2

2

2

1

1

2

0

1

2

2

2

2

2

21

[22]

2

2

2

1

1

2

2

0

2

2

2

2

0

20

[23]

2

2

2

2

1

2

1

2

2

2

2

2

2

23

[25]

2

1

2

1

2

2

2

0

2

2

2

2

2

22

[26]

2

1

2

2

0

2

1

2

0

2

1

2

2

19

[24,27]

2

2

2

1

0

2

1

1

2

2

2

2

2

21

[28,29]

2

2

2

2

2

2

1

2

2

2

2

2

2

25

[30]

2

2

2

1

0

2

1

0

2

2

2

1

2

19

[31]

2

2

2

1

2

2

0

2

2

2

2

2

2

23

[32]

2

2

2

1

2

2

2

1

2

2

2

2

2

24


0 = not reported; 1 = reported but inadequate; 2 = reported and adequate; a 0 for nonrandomized studies and 2 for randomized studies; ITT: intention-to-treat.

Deschodt et al. BMC Medicine 2013 11:48   doi:10.1186/1741-7015-11-48

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