In recent years, medical practice has followed two different paradigms: evidence-based medicine (EBM) and values-based medicine (VBM). There is an urgent need to promote medical education that strengthens the relationship between these two paradigms. This work is designed to establish the foundations for a continuing medical education (CME) program aimed at encouraging the dialogue between EBM and VBM by determining the values relevant to everyday medical activities.
A quasi-experimental, observational, comparative, prospective and qualitative study was conducted by analyzing through a concurrent triangulation strategy the correlation between healthcare personnel-patient relationship, healthcare personnel's life history, and ethical judgments regarding dilemmas that arise in daily clinical practice.
In 2009, healthcare personnel working in Mexico were invited to participate in a free, online clinical ethics course. Each participant responded to a set of online survey instruments before and after the CME program. Face-to-face semi-structured interviews were conducted with healthcare personnel, focusing on their views and representations of clinical practice.
The healthcare personnel's core values were honesty and respect. There were significant differences in the clinical practice axiology before and after the course (P <0.001); notably, autonomy climbed from the 10th (order mean (OM) = 8.00) to the 3rd position (OM = 5.86). In ethical discernment, the CME program had an impact on autonomy (P ≤0.0001). Utilitarian autonomy was reinforced in the participants (P ≤0.0001). Regarding work values, significant differences due to the CME intervention were found in openness to change (OC) (P <0.000), self-transcendence (ST) (P <0.001), and self-enhancement (SE) (P <0.019). Predominant values in life history, ethical discernment and healthcare personnel-patient relation were beneficence, respect and compassion, respectively.
The healthcare personnel participating in a CME intervention in clinical ethics improved high-order values: Openness to change (OC) and Self Transcendence (ST), which are essential to fulfilling the healing ends of medicine. The CME intervention strengthened the role of educators and advisors with respect to healthcare personnel. The ethical values developed by healthcare professionals arise from their life history and their professional formation.
Keywords:clinical ethics; values; continuing medical education; concurrent triangulation strategy; axiology
In the 21st century, medicine tends to be dominated by two paradigms, evidence-based medicine and values-based medicine (EBM-VBM), which directly impact clinical decision-making processes in daily healthcare practicea [1-6].
Modern biomedical science faces the challenge of reinforcing the pairing of EBM-VBM and constructing links and networks between them [7,8]. Continuing medical education (CME) promotes career-long competence with respect to medical advances (EBM); moreover, it can support fine-tuning of professional values and principles (VBM) [1,2,4,5,7,9-12].
Values are normative guidelines that allow us to consider actions, objects or situations as good, desirable, pleasant, convenient or useful towards certain aims . These aims and the values that guide us towards them lend a mindful sensibility to our life and our professional practice . Clinical practice is axiologicallyb complex because it is not limited to describing, explaining or predicting what takes place within the human body (epistemological values: EBM), but it also acts on the bio-psycho-social spheres of a person and relates to his/her dignity [15,16] (social, political and ethical values: VBM). Furthermore, biomedical technical qualities are as important to healthcare as ethical qualities, yet ethical qualities are not always empirically evaluated. Emerging actions, devices and technical/scientific biomedical scenarios present increasing uncertainty and pose exponential risks that underscore the necessity of promoting an analytical-empirical axiology that places practice along a horizon of wisdom [7,17-22].
The healthcare sector is currently facing a crisis of knowledge, compassion, care, cost and values in general; however, few programs have addressed values among healthcare personnel, and little data exist concerning the effectiveness of such programs [23-27]. Values have a strong impact on the decision-making process and the final course of actions . In other words, patients complain more about the lack of courtesy, warmth, understanding, care and communication than about the lack of updated attention protocols.
Values are favorable dispositions towards aims that are sought. A physician is willing to act in accordance with the ends of medicine (healing, curing and caring) because they guide and give sense to his/her practice. These ends in medicine have traditionally been traced by clinical ethics in the form of principles and virtues. Principles state the deontological obligations of healthcare personnel and aim to offer an answer to ethical dilemmas. Principles will always be grounded on values. Principles explicitly state the values that we consider important , they express a normative procedure according to which actions can be guided to reach these values. . Virtue ethics have resolved some of the shortcomings of principlism by arguing for the importance of the character traits and decision-making in moral discussions. If we think of a Venn-Euler diagram, values are the universe, while virtues and principles are subsets. That is, every virtue is a value, but not every value is a virtue; and the same goes for the principles; they are the expression of a normative procedure that is grounded on values, but at the same time they are valuable themselves (Figure 1). However, values have a broader focus, and they encompass virtues and principles alongside other objective goods that must be considered in ethical discernment (Figure 1).
Figure 1. A Venn-Euler diagram of values. Values are the universe, while virtues and principles are subsets. The subset of virtue considers those values that refer directly to the healthcare personnel, their traits of character and decision-making. The subset of Principles expresses a normative procedure according to which actions can be guided to reach certain values .
Life preservation is a value that, in order to be upheld, is supported by several epistemic and ethical virtues and principles. Virtues such as wisdom, temperance and compassion aim at life preservation. In addition, principles such as beneficence are important in preserving life because they specify the obligations and provide explicit guidance to the agents' actions. However, in this paper, we maintain a broad perspective regarding values that allows us to move between virtues and principles and to consider the personal and social dimensions of patients and healthcare personnel in addition to the states of affairs that are valuable in strengthening the convergence of EBM-VBM (Figure 1). We acknowledge the great influence of virtue ethics and the principles of biomedical ethics, but it is our contention that a general and wider analysis can be carried out. Beauchamp and Childress' principles, in fact, express a normative procedure to uphold several values. For example, respect for autonomy demands action on behalf of the physicians towards an agent with the right to hold views and make choices based on personal values and beliefs. This principle specifies the actions to be carried out by someone seeking to uphold the value of autonomy. Therefore, our analysis will consider values as including principles and virtues (Figure 1).
As stated earlier, one of the ways to create a novel ethical environment is through education in clinical ethics. The first step is to carry out a situational diagnosis of what the ends of healthcare are considered to be, along with the values linked to these ends [7,14]. It is thought that when healthcare professionals are aware of these values, they will be guided by more careful reflection to adequately approach the dilemmas that arise [1,2,4,5,7,9-12]. Such reasoning has led us to pursue concurrent triangulation approaches that use quantitative methods to assess expressed values in medical practice and the decisions made when facing three clinical vignettes that pose ethical dilemmas. While capturing what health workers claim to be their values, we use qualitative anthropological methods and ethnography to define the values they display in their daily activities. Thus, we are able to analyze the concordance of such factors as life history, the doctor-patient relationship and ethical judgements regarding dilemmas that arise in the clinical practice.
The study's central hypothesis is that a cross-functional clinical ethics course is able to amalgamate EBM and VBM. Therefore, we seek to address the following questions: (1) What are the values of a group of healthcare professionals participating in CME in clinical ethics? (2) Why and how do participants respond to values in their clinical practice? (3) How does CME in clinical ethics impact the pairing of EBM-VBM? Here, we describe the successful use of CME to engineer networks between EBM and VBM.
A concurrent triangulation design of mixed methods' strategies to analyze both quantitative and qualitative data was used to empirically explore the axiology in the clinical practice of Mexican healthcare professionals , as illustrated in Figure 2. Mixed methods were combined for complementarity, where each method addressed a different aspect of the research questions and highlighted new connections . Quantitative methods were used to determine the self-declared values of clinical practice before and after the CME program. The qualitative semi-structured interviews (SSIs) and three clinical vignettes (CVs) were employed to explore participants' experiences and representation of their clinical practice, with an emphasis on experiences with the patient-healthcare personnel relationship and ethical discernment. We conducted a quasi-experimental, observational, longitudinal, comparative and prospective study that allowed us to describe the state of the art and to strengthen practices favorable to the pairing of EBM and VBM (Figure 2).
Figure 2. Framework of the analytic methodology. In step 1, we used statistical analyses to examine the axiology of clinical practice (values in healthcare, work values, virtues in medical practice and three clinical vignettes posing ethical dilemmas) and the characteristics of participants prior to conducting the CME in clinical ethics. In step 2, we used qualitative content analysis of semi-structured interviews (SSIs) to examine reasons for values usage in clinical practice and axiology in the ethical discernment process prior to conducting the CME in clinical ethics. After quantitative and qualitative research questions were examined, these results were integrated based on the mutual validation model, which regards the search for convergent findings as validity indicators as the most important purpose of triangulation. We explored potentially strong connections between EBM and VBM using qualitative results, while we inferred the extent of the benefits of novel networks using quantitative results. After conducting the CME in clinical ethics intervention, we repeated the analyses (steps 3 and 4), and the full results were integrated.
Mexican healthcare personnel with current active practices in several clinical medical areas were invited to participate in an online course in clinical ethics, at no cost, from September 2009 to February 2010. Registration was conducted during a two-month period prior to the CME program (N = 2,891). During registration, each participant provided his/her demographic data and responded to an online survey (Table 1).
Table 1. Sociodemographic characteristics at two stages
Healthcare professionals who enrolled in the online course represented every Mexican state and organizational level of healthcare. The primary healthcare level is preventive and family medicine. The secondary level comprises different medical specialties and general surgery. The tertiary level includes highly specialized medical attention.
The research ethics committee of the Mexican Institute of Social Security (IMSS) approved the study. All participants received written and oral study information and signed a letter of informed consent granting the authors permission to use and publish the data and results of this study.
CME in clinical ethics Intervention
The course was designed by a cross-functional group (including medical doctors, teachers, anthropologists, sociologists, philosophers and bioethicists), and it included five modules: the person and human dignity, medical ethics, healthcare professional/patient relationship, clinical ethics committees, and methodologies for ethical discernment.
The Anahuac University and the IMSS awarded those who completed the course with a 60-hour CME certification. This on-line course provided information to healthcare personnel about ethical terms, concepts and theories. Additionally, the course reviewed guidelines for ethical decision-making, which included exploration of personal values in addition to problem-solving exercises (patient simulation, motivational videos and online discussion forum) regarding how to apply ethical concepts and theories to ethical dilemmas (Figure 2).
Instrument design (survey)
Although numerous survey instruments measuring values are used worldwide [15,16,32,33], they do not explore the values or virtues specific to medical practice (Figure 3). A set of survey instruments designed by a cross-functional team (an expert panel in clinical axiology) were drafted and initially tested on a small sample of 10 participants; they were subsequently used in this paper. These instruments were used to assess the respondents' values and priorities in healthcare practice before and after the CME program. The survey collected participants' declaration of personal values in addition to measuring their values with respect to healthcare, work and medical practice. The survey also included three clinical vignettes posing ethical dilemmas .
Figure 3. Hierarchy of values in clinical practice in Mexico. Each of the charts shows the state of values before the intervention (n = 2,891). Deontological values are in blue, aretological values are in red, and utilitarian values are in green. The lower the values, the higher their level of importance.
To assess work values before and after the CME intervention, we used an instrument proposed by Schwartz that operationalizes four high-order values  in the work environment. These high-order values encompass a total of 16 items that constitute the EVAT (Escala de Valores hacia el Trabajo) scale . The EVAT scale has been used among large samples of Mexican, Spanish, Portuguese and Italian workers .
Ethical discernment instrument
The survey included three clinical vignettes that were used to assess discernment in some of the common ethical dilemmas encountered in medical practice: patient confidentiality, informed consent (autonomy) and withdrawal of care (beneficence). The clinical vignettes revealed differences in discernment before and after the CME .
Distribution of participants according to gender, age, profession/discipline and healthcare level is described for each of the two phases (Table 1). We explored the before-and-after changes of self-declared values in medical practice. The changes in the before-and-after ranking of these items were determined using the Bonferroni-corrected Wilcoxon signed rank test. Differences among hierarchical items were determined using the Kruskal-Wallis test, followed by the Steel-Dwass test for pairwise comparison. Parametric tests (Student's t-test, and paired t-test) were used for the statistical analyses and were confirmed by non-parametric tests (Mann-Whitney U-test). For the cluster analyses, the mean and standardized values of the aretological, deontological and utilitarian groups were obtained. For the work values analyses, we obtained the means for the group of high order values: openness to change (OC), self-enhancement (SE), self-transcendence (ST) and conservation (CO). These values were illustrated on a three-dimensional scatter plot.
Qualitative study (interview)
The aim of the qualitative component of the study was to explore the self-representations of the healthcare professionals. Purposive sampling was undertaken  to include a range of types of healthcare professionals and a range of types of health institutions. A semi-structured interview guide was designed by an expert panel on clinical axiology and pilot-tested by Nava Diosdado et al. . Briefly, we designed an instrument that would allow us to identify values and to assess career goals in the following categories: life history, career goals, reasons the interviewee joined the profession, working values, how the interviewee resolves his or her day-to-day problems, type of doctor-patient relationships established, projections of the interviewee on his or her patients, attitude towards clinical ethics, and how interviewees see themselves in the next 10 years.
Face-to-face semi-structured interviews were conducted with healthcare personnel by anthropologists. The interviews focused on the personnel's views and representations of clinical practice. The interviews took place between September 2009 and February 2010, before the CME intervention (78 interviews) and after the CME intervention (42 interviews). Interviews lasted approximately 80 minutes and were recorded and later transcribed.
The transcriptions of interviews were analyzed using the content and thematic analysis method described by De Hoyos et al.c. Briefly, all data were analyzed following five steps: familiarization with the data through listening and immersion in the raw data several times, identification of a framework, coding, charting and interpretation. An axiological framework was developed in line with Schwartz's work values and Pellegrino and Oakley and Cocking's findings regarding the virtues and vices of healthcare professionals. The main emerging themes were representations of medical practice. Beliefs, desires, meanings and their axiological interactions structure of clinical practice were studied. One hundred codes were grouped according to the following subjects: life history, workday, ethical discernment, patient-doctor relationship, medical procedures, decision making, ethics committee and future expectations of healthcare personnel.
For both sets of interviews, Atlas.ti 6.0 softwared was used to identify emergent themes in addition to the views of the participants. Each interview ended with the presentation of short vignettes concerning clinical cases. The use of vignettes with open-ended questions in qualitative research attempts to determine perceptions, attitudes and moral values, all of which are particularly pertinent for this study . Codification and analysis were performed by the cross-functional team. The chart was thoroughly discussed and interpreted in meetings among all members of the cross-functional team (Figure 2).
Data analysis for ethics
We used an inductive, ethics-based process of analysis, following Josep Lozano's classification of ethical theories founded on three major approaches [39,40]: the first one is virtue (or aretological) ethics, where goodness is determined in relation to the type of moral agent involved and the context of his/her actions. The second is deontological (that is, duty or rule) ethics, where the emphasis is placed on the generality of the rules and their rationality. Finally, there is utilitarian ethics, which identify the good with its consequences. The utilitarian principle demands the maximization of the good produced by one's actions.
These approaches allow the specification of which values are in conflict for a given ethical dilemma: the confrontation between virtue and duty, virtue and efficiency, or duty and efficiency. The cross-functional research team identified codes for units of meaning in the survey.
Axiological situational diagnostic data were obtained for 2,891 healthcare professionals who were initially enrolled in the course (registration). The final sample included 973 healthcare professionals who successfully completed the course and who had also completed the before-and-after survey instruments as well as the clinical vignettes. Table 1 shows the socio-demographic features of the healthcare personnel during the two stages of the study.
We confirmed that the 973 participants of this study represented the initial participants in the course, using demographic and professional survey information. No differences were found with respect to factors such as professional distribution, gender, age, organizational level of healthcare or geographic distribution.
Most of the participants were female (62%). The predominant profession was physician (57%), followed by nurse (20%). Participants' ages ranged from 17 to 82 years, with 43.5% of the participants being between 36 and 50 years of age (median age of 44 years). The healthcare personnel represented different regions of Mexico. The sample included the four organizational levels of Mexican healthcare: first level, 41%; second level, 32%; third level, 22%; and central level, 5%.
Of the participants, 40% had prior training in bioethics through courses taken during their higher education. Participants' primary motivation to enroll in the course was to improve their professional performance (54.6%), followed by the desire to increase their knowledge of clinical ethics (36.3%).
Axiology in clinical practice
The values of clinical practice refer to favorable attitudes, actions and situations that will help to achieve patients' wellbeing. The priorities and value rankings of 2,891 participants are shown in Figure 3. The values of clinical practice differed significantly before and after the educational intervention (Figure 4).
Figure 4. Hierarchy of values in clinical practice before and after CME intervention. All the values presented statistically significant change before and after the intervention (Wilcoxon Signed Rank Test with Bonferroni's correction).
Healthcare professionals in Mexico assigned great importance to the values of 'honesty' and 'respect' by placing them first and second, respectively, in their hierarchy of values, whereas a low level of importance was given to values such as 'fidelity', 'purity' and 'beauty'. Notably, the two highest and the three lowest values in the ranking remained unchanged after the clinical ethics course (Figure 4).
The value of 'autonomy' was ranked high (third) by the participants after completing the course, whereas prior to the course, it was ranked 10th (mean position shift from 8.00 to 5.86, a statistically significant difference) (Figure 4). Other values deserving attention were 'justice', 'liberty', 'love' and 'charity'; these values assumed higher hierarchical positions after the CME intervention (statistically significant, (Figure 4)).
Figure 5 shows the ethical clusters found in Mexican healthcare personnel based on Josep Lozano's classification of ethical theories (aretological, deontological and utilitarian) . The first group is deontological/utilitarian; the second, aretological/deontological; the third, mainly aretological; and the fourth, aretological/utilitarian.
Figure 5. Ethical clusters found among Mexican healthcare personnel. Aretological values are A; deontological values are D; utilitarian values are U. Before (1) and after (2) the educational intervention.
Ethical dilemmas and values
A dilemma is a situation in which a person may choose only one of two courses of action, each of which seems to be well supported by certain values. The survey encompassed three clinical vignettes . We assessed the clinical vignettes following Gisondi's definitions of each value  in a representative sample of 448 participants. We assigned the maximal score to 'patient confidentiality' when "the healthcare professional does not discuss clinical or confidential information about a patient with others"  or only disclosed information in the case of risk to public health. Confidentiality was one of the strongest values for participants and was not modified by the educational intervention (P = 0.06). For 'beneficence', we assigned the highest score to situations where "healthcare personnel identify the surrogate decision maker, obtain paperwork for advance directives, withdraw care when appropriate, and when needed, requested some form of palliative care for a patient" . This value was present among healthcare professionals working in Mexico and was not modified by the educational intervention (P = 0.1618).
The value of 'autonomy' was labelled as 'utilitarian autonomy' when healthcare personnel attempted to obtain informed consent or voluntary discharge, and 'deontological relationship-based autonomy' was a situation in which "the health personnel attempted to obtain informed consent from the patient or surrogate by explaining common risks, benefits, and alternatives (including no intervention), while querying for and answering patient questions in an unbiased fashion" . Educational intervention had an impact on both types of autonomy (P ≤0.0001). Utilitarian autonomy was largely reinforced in the participants (P ≤0.0001).
According to Schwartz , individual behavior is highly influenced by a specific set of values that the agent finds important. As observed in Table 2, the differences encountered between the means on openness to change (OC) and self-transcendence (ST) before and after CME intervention were highly significant (P <0.001) according to the values of the t tests. These results allow us to confirm our central hypothesis that we can engineer strong connections and networks between EBM and VBM through CME (Figure 6A-D). Individuals who assign a high priority to the high-order value of ST tend to be more satisfied in their jobs because they introspectively evaluate their professional values and find them to be aligned with the ends of medicine  (Figure 6A-D).
Table 2. Work values
Figure 6. Four high order values (Schwartz's theory) before and after CME intervention. Each row includes N = Nurses, M = Medical Doctors, HP = Others Healthcare Professionals. A = Administrative personnel. Spheres in red are females. 1 = Before and 2 = After educational intervention. A: Scatter plot in 3D. Openness to Change. Spheres representing post-CME intervention appear compacted. B: Scatter plot in 3D. Self-transcendence. Spheres representing post-CME intervention appear compacted. C: Scatter plot in 3D. Self-Enhancement. D: Scatter plot in 3D. Conservation.
Qualitative content analysis
To strengthen the knowledge claims of the study, the declared values considered in the quantitative analysis were paired with a qualitative analysis that aimed to gain insights into the representations of the actors and their beliefs. A well-validated study on a subject such as clinical ethics and values would be incomplete without both quantitative and qualitative perspectives.
The rise of vocation and its consolidation
When qualitatively tracing the most salient values in the life history of the individuals interviewed, we found that healthcare personnel referred to a core of values, where beneficence is dominant together with tradition, incentivizing, achievement and conformity, and that those traits led them to choose a career in the medical field (Figure 7A). Self-transcendence (ST) is analytically divided into 'beneficence' as a concern for those with whom one is in contact. 'Universalism' is an abstract sense of goodwill with respect to the health of the general population. Although both values were included in the healthcare personnel's representations, beneficence was predominant (Figure 7A).
Figure 7. Semantic networks. Keywords were identified with Atlas.ti 6.0 software. Words were sorted according to the frequency of their appearance in the interviews. The cut-off point, which divides the set of words into a high-frequency and low-frequency groups, was identified. Radial graphs explaining the frequency of appearance were created with MS Excel 2007. Red indicates before CME, and blue indicates after CME. A: Semantic Networks for Life History. B: Semantic Networks for Ethical Discernment. C: Semantic Networks for Healthcare Personnel-Patient Relationship.
The configuration of beneficence as a guiding value for the vocation of these professionals is associated with two different and sometimes conflicting sources. In one, social relations are protected through conformity with established values and traditions; in the other, innovations in these values are made when incentives encourage new achievements in the medical field (Figure 7A).
The educational intervention permitted the rediscovery of certain values that would consolidate the vocation of the healthcare personnel; even if the participant's perspective shifted, the centrality of beneficence remained. Self-direction and incentivizing came to play an important role once the professionals acquired greater experience, and this experience supported improved knowledge and performance. While self-direction and incentivizing demonstrate an openness to change, they are still well balanced with the protection of social relationships through adherence to prevailing values (Figure 7A and Table 3).
Table 3. Values and healthcare personnel roles
Daily medical practice encounters ethical dilemmas when treatment efficiency and other related values must be taken into account to help the physician make a wise decision. The basal values that are most often cited in healthcare professionals' representations are justice, respect, medical attention, an ability to appraise situations and their consequences, compassion and beneficence, followed by compliance with norms and autonomy (Figure 7B).
Autonomy, beneficence, justice and non-maleficence are the values suggested by Beauchamp and Childress' principlism for ethical discernment. As stated in the background section, principles express normatively a procedure to uphold a value (Figure 1). In this case, we analyze directly the values that are reached through these principles. However, our data show that autonomy was not a founding value in the ethical-discernment for healthcare professionals prior to CME; rather, among these four values, justice is relevant and precedes the rest, and beneficence is second. Both values relate to ethical judgement (Table 3 and Figure 7B).
In the analysis, with the exception of justice, values such as respect and compassion were considered more relevant to ethical judgment than the remainder of the values related to principlism (Figure 7B). Respect and compassion demonstrate that the patient-doctor relationship is understood in different ways that aim to approach the patient with dignity. In general terms, the interviewees described a discernment that is justice-centered. (Table 3 and Figure 7B).
Additionally, we investigated the interviewees' representations of how medical attention should have an impact. Generally, the medical practitioner described not making decisions based on the notion of an ultimate end of the practice but rather on the ability to appraise specific situations. The ability to appraise situations is, of course, useful in maintaining life and avoiding risks, but it also helps to clarify courses of action in ethically complex cases (Table 3 and Figure 7B).
The educational intervention modified participants' configuration and hierarchy of values. After the CME intervention, values such as respect, compassion and justice were predominant over the others. Autonomy moved from the eighth position to the fourth position according to importance (Figure 7B).
Healthcare personnel-patient relationship
Different kinds of relationships between patients and healthcare personnel
We were able to discern a bundle of values in the specific relationships that we studied. The initial values that prevailed in this relationship were self-direction, justice, medical attention, compassion and beneficence. Again, we noticed that the values related to virtue ethics are stronger than those related to principlism (Figure 7C).
Medical attention, the main role played by healthcare professionals
In describing their functions, all interviewees quickly noted that their job was to provide medical attention; they were all immediate and precise in their description. The medical practitioners eloquently spoke about the different types of patient they meet; they recognized in advance the types of persons and diseases they would encounter (Table 3).
In relation to the particular situations in medical attention in which the link with the patient is the common denominator, we found that values such as compassion, justice and beneficence, self-effacement and trust are salient (Table 3 and Figure 7C).
The health professionals showed great patience when working with patients after the CME intervention. Issues that would normally act as a barrier between the health professional and the patient became an opportunity for the health professional to provide the patient with comprehensive medical care. The healthcare personnel stated that when patients abandon their treatment against medical advice, reactions such anger, disappointment or discomfort are not uncommon. Following the CME intervention, they resolve these issues by informing patients about the treatments and their benefits. Educating patients implies transmitting scientific information that provides them with some certitude regarding their treatment in general. This information must be provided in an understandable and non-condescending way (Table 3).
Virtues in clinical practice
One way of creating a novel ethical environment and improving the quality of medical care is fostering new values to face the challenges of clinical practice. Among the different values that are important for medicine, we find several virtues. Virtues are values that refer directly to the healthcare personnel, their traits of character and decision-making (Figure 1). Hence, special attention must be paid to the virtues that are fostered in clinical practice because well-established character traits will help practitioners make sense of their own practice and, at the same time, pursue the valuable ends of medicine. A community has some well-established virtues, but critical reflection of these values may stimulate changes. The main virtues endorsed by healthcare personnel in Mexico are 'trustworthiness', 'intellectual honesty' and 'beneficence', followed by 'fortitude', 'compassion' and 'courage'. The CME intervention had a significant strengthening effect on these virtues among the participants (Figures 4 and 8).
Figure 8. Virtues of medical practice. *Denotes a statistically significant difference before and after the intervention (Wilcoxon Signed Rank Test with Bonferroni correction). Vertical lines tie the pair of values between which no statistically significant difference was found (Steel-Dwass All Pairs Comparison).
Our results demonstrate that the healthcare personnel participating in a CME intervention in clinical ethics improved high-order values Openness to Change and Self-Transcendence, as observed through a concurrent triangulation approach (Figures 6A, Band 7A-C and Table 2). Quantitative analysis showed that even if core values, such as honesty and respect, remained unchanged after educational intervention, other important values for the healthcare professional-patient relationship were changed (for example, justice, autonomy, love and charity). Moreover, the representations of values found in the qualitative analysis are compatible with the preceding results (compassion, justice, beneficence). In both cases, deontological and aretological values are susceptible to change in such a way as to fulfil the healing aims of medicine .
Ethical discernment is a daunting task from the perspective of integral ethics, which seeks the good of the patient by integrating the three characteristics of action: as a moral agent, as a process to be evaluated from the perspective of rights and duties, and with respect to the consequences of the action. This approach ensures that healthcare professionals exercise their hierarchy of values (Figure 4 and 8).
Following Lozano, dilemmas can arise from different areas; different values and different kinds of ethics take precedence. Values consider the good that is to be achieved through a practice. However, when several of these values are in conflict and a decision cannot be reached, virtue becomes central in solving an ethical problem; the character, practical wisdom and experience of the practitioner are important resources for ethical deliberation (Figure 8) [7,9,12,14,42,43].
CME must focus on four areas to strengthen the EBM-VBM binomial: The first area is extensive knowledge of the pathophysiology of disease and availability of real therapeutic alternatives (EBM). The second area is knowledge and awareness of values (VBM). The third one is development of an ability to analyze and discern ethical dilemmas (VBM), and the fourth area is communication skills (VBM) [44,45].
In this study, we validated our instrument (a value hierarchy in clinical practice) and identified the opportunity for CME intervention. Figure 3 demonstrates that participants recognized that, to act fully as providers of medical assistance, advisors and educators, the most important values are honesty, respect and autonomy. These values are similar to those enumerated in the literature . These specific roles lend a multi-dimensional character to the patient-healthcare professional relationship. Our results (Table 3) show that the most established role in this group of professionals is that of a provider of medical assistance; however, the CME intervention successfully developed bridges and networks to improve the practitioners' performance in the role of educator and adviser.
A notable outcome of our CME clinical ethics course is that it created awareness among physicians and healthcare professionals of how their decisions are made and the values that are at stake (Figures 3, 4, 5, 6, 7, 8). Moreover, the intellectual exercise involving several ethical perspectives ensured that healthcare professionals deliberated in a comprehensive and thoughtful manner (Figures 3, 4, 5, 6, 7, 8).
We propose that an integral approach to ethics similar to the one described by Polo  is the solution to the increasing number of ethical dilemmas in medicine. Such an approach considers three features of ethical discernment: 1) The best decision is an integrated one that does not spring from isolated principles but one that allows the moral agent to consider due processes in a given context, as well as his/her own virtues in determining a course of action . Therefore, deontological, aretological and utilitarian criteria may overlap in decision making.
2) These criteria emphasize different issues involved in an ethical dilemma. A deontological criterion focuses on the fulfilment of general and comprehensive rules. A focus on virtue is more capable of addressing the immediate context. Moreover, a value such as efficiency should not be neglected in the healthcare professions. However, the specific configuration of the dilemma and the moral character of those involved will reveal which criteria should be prioritized in a process of wide reflexive equilibrium [47,48].
3) The most important criterion for decision making is the respect for the universal trait of human dignity, even if those who address this dilemma conceive of it in different manners. Dignity supports the individual in acting conscientiously and making his/her own life choices [49,50].
It is of the utmost importance to keep in mind the primacy of those affected by the decisions, ethical values and discernment of healthcare personnel. However, the decisions made by healthcare personnel not only affect patients but also the decision-makers themselves. These decisions determine what kind of person and professional one becomes, how sensitive one is towards others, and how attentive one is towards one's own needs. The best decisions justifiably solve a dilemma by integrating different ethical theories related to human actions. An integrated ethics approach is essential in medicine because medicine is concerned with the person and his/her interests, needs, vocation, virtues and transcendence.
In a nutshell, we can say that the CME intervention favors the creation of networks between EBM and VBM from a philosophical, epistemic, axiological and practical point of view. From the philosophical point of view, we were able to recover the ends of medical practice, namely: healing, curing and caring, the recognition of the person as central to healthcare. This is evident in Table 3 where after the CME intervention; the representations and beliefs of the healthcare personnel were modified, and exhibited a more thorough understanding of the philosophy of medicine. From the epistemic point of view, the epistemic values that are related with medical attention were strengthened. Simultaneously, we perceived increased knowledge related to integral ethics. This can be seen in Table 3 and Figures 3, 4, 5, 6, 7, 8, where the physicians' roles were more balanced. The promotion of personal growth through the exercise of values, such as autonomy, love, justice and freedom, could be seen. These values were rediscovered and used to improve the patient-healthcare personnel relationship. Both the quantitative (Figures 3, 4, 5, 6), and the qualitative (Figures 7 and 8, and Table 3) analyses show the construction of links between EBM and VBM. From a practical perspective, tools for ethical discernment were provided, discursive spaces to reflect and critically analyze ethical dilemmas in clinical practice were created.
In ethical discernment, the use of clinical vignettes to picture situations with moral dilemmas proved useful. In these exercises autonomy stands out, it was a value previously overlooked and it became relevant for the healthcare personnel after the CME intervention. Additionally, ethical committees as guarantors of the humanization of healthcare were consolidated, while the promotion of a professional environment directed by academic, ethical and social excellence was encouraged. Strengthening values-based medicine automatically strengthens the EBM-VBM binomial given that they become more balanced. This is clearly shown in the present study. We are looking forward to continuing with the next phase of this project, which involves carrying out participant observation of the active healthcare personnel in medical units, in order to follow up on these results in the long term. This study is one of the first to explore the axiology of clinical practice. Different values and representations may be found depending on the studied population; however, we consider that the empirical method used to explore the representations of these professionals opens a window of opportunity for CME insofar as it strengthens the already-existing values among healthcare personnel; and at the same time, it promotes values that are missing but essential to an effective patient-healthcare personnel relationship. One dimension of medical responsibility involves being attentive to the values that need to be exercised. López Quintás  explains that this attentiveness requires certain value-sensitivity: an ability to discover and recognize the fertility that values have in our lives, when they offer authentic possibilities for personal growth.
This is the first endeavor to empirically investigate the axiological foundations of healthcare professionals working in Mexico. It has long been known that values education is one of the most effective methods to meet the challenge of providing high-quality care to populations and improving the patient-healthcare professional relationship [1,11,44]. Even if different configurations of these values operate in each medical environment, by identifying the values already held in high esteem and those that need to be encouraged, we are certain that these benefits can be extended globally to every level of care.
For CME design purposes, we successfully engineered networks between EBM and VBM. Using the combined approach of cross-functional design, online technology, motivational videos, pictures and real-time decision-making, these networks identified the advantages of both paradigms. Perhaps the CME methods used in this study will encourage the humanization of medicine through routes not open to traditional CME methods, thus potentially allowing access to more efficient CME solutions, as in the example presented here.
It has long been speculated that CME in clinical ethics in real time may be a useful platform for engineering novel networks between EBM and VBM. Our strategy of cross-functional CME in clinical ethics may be of broad application in achieving high-quality care.
CASC: capacity to appraise situations and consequences; CME: continuing medical education; C/N: compliance with the norm; CO: conservation; CVs: clinical vignettes; EBM: evidence-based medicine; EVAT: Escala de Valores hacia el Trabajo, Spanish for work values scale; IMSS: Mexican Institute of Social Security; OC: openness to change; OM: order mean; SE: self-enhancement; SSIs: semi-structured interviews; ST: self-transcendence; VBM: values-based medicine
The authors declare that they have no competing interests.
MMAB and NFAB conceived and designed the present study, while MMAB, MTAO, SQV, JM, RND and ACD collected and assembled the data. MMAB, NFAB, AL, IMM, AdH, CM, SQV, JM, RND, FVG, RV, EC, PS and JMMA contributed to analyzing and interpreting the data. MMAB, NFAB, AL, IMM and AdH drafted the article. MMAB, NFAB, AL, AdH, FS, PS, CM, JMMA, FVG, JG, SIA, MTAO, JAA, OMG, ARF and JKR revised the article for important intellectual content. All authors gave their final approval.
aOf these two paradigms, EBM appears to predominate: Medline displays 49,491 EBM articles versus 1,701 articles addressing Humanistic Medicine, Patient-Centered Medicine or VBM. bAxiology is the philosophical discipline that studies values and the phenomena surrounding them. cDe Hoyos A, Nava-Diosdado M, Mendez J, Ricco S, Serrano C, Macias-Ojeda C, Cisneros H, Bialostozky D, Altamirano-Bustamante N, Altamirano-Bustamante MM: Cardiovascular medicine at face value: a pilot qualitative study on clinical axiology. Philos Ethics Humanit Med 2013 (accepted). d ATLAS.ti Scientific Software Development GmbH, Berlín, Germany.
We are indebted to all of the professors and participants who were involved in the on-line clinical ethics course. We are also grateful to the staff of the Direction of Innovation and Technology of the IMSS and ISAPEG for helping us to reach our goal. We greatly appreciate the work of Ana Serrano, Carlos Macías, Uria Guevara and Sandra Lizarraga for their help in data coding and for their participation in fruitful discussions. We appreciate the help of Juan Jimenez in designing the Figures for this paper. Adalberto de Hoyos would like to acknowledge the support provided by the postdoctoral fellowship program at UNAM. The authors are also indebted to the healthcare personnel who generously shared their experiences in the interviews. We also wish to thank Dr. Israel Grijalva Otero for his support. We want to thank Isaac Fernández, our computer guru, for all his support.
Funding for this study was provided by Mexico's Council of Science and Technology (CONACYT) 068673 and the General Direction of Academic Personnel Affairs of UNAM (DGAPA) for the Papiit project ID 400112.
Vertex 2010, 21:450-458. PubMed Abstract
Mt Sinai J Med 2002, 69:378-384. PubMed Abstract
Natl Forum 1978, 58:13-17. PubMed Abstract
Trans Stud Coll Physicians Phila 1987, 9:179-191. PubMed Abstract
St Thomas Law Rev 2001, 13:815-825. PubMed Abstract
J Cross-Cult Psychol 2001, 32:519-542. Publisher Full Text
Arciniega LM, Gonzalez L, Soares V, Ciulli S, Giannini M: Cross-cultural validation of the work values scale EVAT using multi-group confirmatory factor analysis and confirmatory multidimensional scaling.
Span J Psychol 2009, 12:767-772. PubMed Abstract
Nava Diosdado R, Flores Cisneros C, Méndez Jiménez J, Serrano Zamago AB, De Hoyos A, Ricco Monge S, Altamirano-Bustamante NF, Altamirano-Bustamante MM: Valores en medicina: etnografia de sus representaciones en un hospital de cardiología en México.
Ethical Perspectives 2003, 10:46-65. Publisher Full Text
Altamirano-Bustamante N, Bobadilla Aguirre, Altamirano-Bustamante E, Garduño J, Ávila Osorio MT, Muñoz Hernández O, García Pavón R, Altamirano-Bustamante MM: Rethinking ethical decision-making in pediatrics. [http://www.medigraphic.com/pdfs/bmhim/hi-2010/hii103b.pdf] webcite
Laín-Entralgo P: La relación médico-enfermo. Madrid: Alianza; 1983. PubMed Abstract
Sulmasy DP: Dignity and bioethics: history, theory, and selected applications. In Human Dignity and Bioethics Essays Comissioned by the President's Council on Bioethics. Edited by the President's Council on Bioethics.... Washington, DC: US Independent Agencies and Commissions; 2008::476-480.
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