Combined treatment decreases B-cell lymphoma 2-associated X protein (Bax) expression in the spinal cord of mice with late-onset spinal muscular atrophy (SMA). (A, D, G) Western blots showing Bax and caspase 3 expression in spinal cord samples from wild-type (WT) mice or mice with late-onset SMA on postnatal days (PNDs) 15 (A), 30 (D) and 90 (G) that received vehicle, L-ascorbic acid (L-AA) or L-AA combined with sodium vanadate (SV) (n = 3 in each group). (B, C, E, F, H, I) Quantification of the western blot results in (A), (D) and (G). The mean ± SEM was calculated. *P < 0.05, **P < 0.01 and ***P < 0.001, Student's t test.
Liu et al. BMC Medicine 2013 11:38 doi:10.1186/1741-7015-11-38