L-Ascorbic acid (L-AA) protects against sodium vanadate (SV)-induced toxicity in a mouse model of late-onset spinal muscular atrophy (SMA). (A) Schematic indicating the treatment regimens used in this study. (B) The mean body weight progression of the wild-type (WT) mice (n = 10, black squares) and the SMA mice that received vehicle (n = 25, pink solid triangles), SV (n = 30, green open triangles), L-AA (n = 30, blue solid circles) and SV combined with L-AA (n = 36, red open circles) treatment. Note that SV treatment reduced the rate of body weight gain. (C) Survival analysis of mice that received different treatments. Note that by postnatal day (PND) 25, most of the mice that had received daily SV administration had died.
Liu et al. BMC Medicine 2013 11:38 doi:10.1186/1741-7015-11-38