Table 5

Maternal serum levels of the validated PE biomarkers
Analyte PE trend Unit Early stage Late stage
Normal PE Normal PE
Median Mean Median Mean Median Mean Median Mean
(IQR) (SD) (IQR) (SD) (IQR) (SD) (IQR) (SD)
PIGF pg/ml 413.8 529.4 97.5 115.5 222.279 238.1095 184.488 202.6929
(224.9, 685.2) (432.0) (51.6, 190.7) (83.0) (163.6, 289.9) (111.5) (113.2, 223.8) (132.7)
sFlt-1 pg/ml 1697.9 3034.0 19841.3 18646.3 5610.460 5531.241 14216.20 14414.28
(1128.2, 4273.9) (2578.7) (15728.4, 21608.6) (3582.5) (4191.8, 6735.8) (1811.9) (12347.6, 19749.3) (5575.3)
HPX ug/ml 1071.2 984.1 1382.8 1580.7 954.4 894.15 1482.0 1347.624
(692.4, 1301.0) (388.3) (1173.6, 1787.0) (546.5) (538.0, 1131.6) (331.5) (1013.6, 1654.4) (585.3)
ADAM12 pg/ml 511.3 584.0 775.0 920.2 666.4185 703.6862 883.889 1345.369
(437.7, 642.3) (275.8) (637.2, 1150.2) (416.4) (594.9, 791.8) (217.2) (626.7, 1367.6) (1472.5)
APO C-III ng/ml 341.3 364.7 419.2 486.3 291.58 321.8587 453.789 585.7512
(249.5, 422.4) (153.4) (357.3, 575.5) (187.5) (240.7, 345.7) (126.7) (308.9, 725.8) (413.1)
HP ug/ml 1624.1 1718.0 1181.6 1482.7 1806.74 1750.72 985.616 1510.514
(1216.0, 2274.1) (764.1) (684.6, 1794.1) (1284.6) (1190.1, 2163.1) (684.1) (592.0, 1880.8) (1515.0)
A2M ug/ml 5796.4 5729.1 3365.1 4259.3 8141.38 7754.764 3435.427 4340.768
(3501.2, 7737.6) (3064.1) (2648.3, 9959.0) (2175.8) (5300.6, 10234.1) (3265.1) (2343.7, 6752.9) (2862.5)
APO-E ug/ml 290.6 364.4 138.8 215.9 398.0 377.9 147.2 150.0235
(104.2, 519.0) (301.5) (63.0, 210.4) (257.6) (125.0, 478.4) (236.3) (60.4, 190.0) (107.7)
APO A-I ng/ml 7980.1 8337.7 4945.356 4708.5 6253.298 6748.614 4724.142 5483.643
(5775.7, 11076.6) (3158.7) (3892.8, 5824.6) (1707.1) (5624.1, 7881.8) (2287.6) (3138.6, 7075.3) (3794.9)
RBP4 ng/ml 38255.0 35180.4 38899.0 36931.7 41616.5 49253.5 33179 33897.47
(29018.5, 40955.5) (7031.1) (33460.5, 39895.0) (7307.5) (38830.5, 44429.5) (38081.6) (29558, 37386) (8499.8)
pikachurin ng/ml 601.8 659.1 293.261 327.8 536.551 536.551 317.657 317.657
(563.8, 792.1) (152.0) (267.4, 367.8) (117.5) (459.2, 626.6) (952.3) (266.8, 409.7) (623.5)

IQR: interquartile range; PE: preeclampsia; SD: standard deviation.

Liu et al.

Liu et al. BMC Medicine 2013 11:236   doi:10.1186/1741-7015-11-236

Open Data