Table 2

Commercially available LPAs for TB detection in clinical specimens
Assay Manufacturer Method Material Sensitivity,% (95% CI) Specificity,% (95% CI) References
INNO-LiPA Rif.TB InnoGenetics, Gent, Belgium PCR amplification/hybridization DNA from decontaminated smear-positive sputum 93.0 (92.0 to 94.0) 83.0 (81.0 to 85.0) [29,30]
INNO-LiPA Rif.TB InnoGenetics, Gent, Belgium PCR amplification/hybridization DNA from decontaminated smear-negative sputum 65.0 (58.0 to 71.0) 96.0 (94.0 to 97.0) [29-32]
Hain GT MTBDRplus Hain Lifescience GbmH, Nehren, Germany PCR amplification/hybridization DNA from decontaminated sputum 92.0 (90.0 to 94.0) - [33,34]

CI, confidence interval; LPA, line-probe assay.

Drobniewski et al.

Drobniewski et al. BMC Medicine 2013 11:190   doi:10.1186/1741-7015-11-190

Open Data