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Open Access Highly Accessed Research article

A novel serogenetic approach determines the community prevalence of celiac disease and informs improved diagnostic pathways

Robert P Anderson1234*, Margaret J Henry5, Roberta Taylor6, Emma L Duncan78, Patrick Danoy127, Marylia J Costa12, Kathryn Addison7, Jason A Tye-Din123, Mark A Kotowicz59, Ross E Knight10, Wendy Pollock6, Geoffrey C Nicholson118, Ban-Hock Toh6, Matthew A Brown7 and Julie A Pasco59

Author Affiliations

1 The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia

2 Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia

3 Department of Gastroenterology, The Royal Melbourne Hospital, Melbourne Health, Grattan St, Parkville, Victoria 3050, Australia

4 Current address: ImmusanT, Inc., ImmusanT Inc., One Kendall Square, Building 200, LL, Suite 4, Cambridge, MA 02139, USA

5 School of Medicine, Deakin University, Geelong, Victoria, Australia

6 Healthscope Pathology, Melbourne, Victoria, Australia

7 Human Genetics Group, University of Queensland Diamantina Institute, Level 5, Translational Research Institute, 37 Kent St, Woolloongabba, QLD 4102, Australia

8 Endocrinology, Royal Brisbane and Women’s Hospital, Butterfield Rd, Herston, QLD 4029, Australia

9 NorthWest Academic Centre, Department of Medicine, The University of Melbourne, St Albans, Victoria, Australia

10 Geelong Gastroenterology, Level 1, 83 Myers St, Geelong, Victoria 3220, Australia

11 Rural Clinical School, School of Medicine, The University of Queensland, Toowoomba, QLD 4350, Australia

12 Current address: Roche Diagnostics Australia, 31 Victoria Avenue, Castle Hill, New South Wales 2154, Australia

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BMC Medicine 2013, 11:188  doi:10.1186/1741-7015-11-188

Published: 28 August 2013

Additional files

Additional file 1: Tables S1:

(A) Baseline serogenetic findings and follow-up in females with confirmed abnormal transglutaminase 2/deamidated gliadin peptide (TG2/DGP) lgA/lgG when recruited 1994 to 1997. (B) Baseline serogenetic findings and follow-up in men with confirmed abnormal composite TG2/DGP lgA/lgG at recruitment during the period 2001 to 2006.

Format: TIFF Size: 1.5MB Download file

Open Data

Additional file 2: Table S2:

Persistent or reproducible abnormal serology in 597 women at baseline and 10 years later.

Format: TIFF Size: 8MB Download file

Open Data