Table 1

Associations between hyperferritinemia and autoimmune diseases
Hyperferritinemia (%) Described associations between hyperferritinemia and autoimmune diseases
RA 4% [7] ✓ High concentrations of ferritin are found in synovial fluid and synovial cells of RA patients [5].
✓ Significant correlations described between serum ferritin levels and disease activity by DAS28 score in RA patients [5].
MS 8% [6,7] ✓ Loss of ferritin binding is involved in, or is a consequence of, demyelination associated with MS [4].
✓ Ferritin levels are significantly elevated in the serum and the cerebrospinal fluid only in chronic progressive active patients [4].
✓ Hyperferritinemia is associated with male gender and a more progressive type of MS (that is, relapsing-progressive), whereas an inverse association was noted between the milder form of disease (relapsing-remitting) [6].
SLE 23% [7] ✓ Serum levels of ferritin during the more active stage of SLE exceeded those of RA patients and patients at less active stages of SLE [3].
✓ Hyperferritinemia is associated with serositis and hematological manifestation [4].
✓ ECLAM score is significantly higher in patients with hyperferritinemia [5].
✓ Hyperferritinemia is associated with thrombocytopenia, lupus anticoagulant and anticardiolipin antibodies in SLE patients with active disease [5].
APS Primary APS 8% ✓ In patients with APS syndrome, hyperferritinemia is associated with the presence of venous thrombotic events, cardiac, neurological and hematological manifestations [8].
Secondary APS 9% [8]

APS antiphospholipid syndrome, DAS28 Disease Activity Score 28, ECLAM European Consensus Lupus Activity Measurement, MS multiple sclerosis, RA rheumatoid arthritis, SLE systemic lupus erythematosus.

Rosário et al.

Rosário et al. BMC Medicine 2013 11:185   doi:10.1186/1741-7015-11-185

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