RTS,S vaccine efficacy estimates at different levels of ML ratio measured before vaccination. In (A), the predicted efficacy (bold line) and 95% confidence intervals (dashed lines) of the RTS,S vaccine are shown in relation to the pre-vaccination ML ratio following bootstrap analysis of a Cox regression model predicting time to first clinical malaria episode with RTS,S vaccination, pre-vaccination ML ratio and an interaction term for both variables as covariates. In (B), the distribution of pre-vaccination ML ratios for all the 610 children included in the study is shown.
Warimwe et al. BMC Medicine 2013 11:184 doi:10.1186/1741-7015-11-184