Open Access Research article

Peripheral blood monocyte-to-lymphocyte ratio at study enrollment predicts efficacy of the RTS,S malaria vaccine: analysis of pooled phase II clinical trial data

George M Warimwe1*, Helen A Fletcher1, Ally Olotu2, Selidji T Agnandji34, Adrian VS Hill1, Kevin Marsh25 and Philip Bejon25

Author Affiliations

1 The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, United Kingdom

2 Kenya Medical Research Institute-Wellcome Trust Research Programme, P.O. Box 230–80108, Kilifi, Kenya

3 Medical Research Unit, Albert Schweitzer Hospital, B.P. 118, Lambarene, Gabon

4 Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany

5 Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Oxford OX3 7LJ, United Kingdom

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BMC Medicine 2013, 11:184  doi:10.1186/1741-7015-11-184

Published: 21 August 2013

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Additional file 1:

STROBE checklist.

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Additional file 2:

Relationship between peak anti-circumsporozoite protein antibody titers and ML ratio. Spearman’s rank correlation coefficient is used to assess the relationship between pre-vaccination ML ratios and the peak IgG antibody response to the circumsporozoite protein, presented as enzyme-linked immunosorbent assay unit (EU) per milliliter, among RTS,S vaccinees. Responses among children in the control group were very low or undetectable throughout follow-up.

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