Table 2

Examples of tumor-specific biomarkers to determine eligibility for targeted therapy
Disease Biomarker Drug References
Colorectal cancer KRAS Cetuximab, panitumumab [1,2,11,13,27,86,98,108],[125,143,144]
Breast cancer Estrogen receptor Tamoxifen [28-31]
Breast cancer Human Epidermal Growth Factor Receptor 2 (HER 2) Trastuzumab, pertuzumab, lapatinib, trastuzumab emtansine (TDM1) [1,2,11,27,125,145-154]
Melanoma BRAF Vemurafenib, dabrafenib [34,112,155-157]
Non-small cell lung cancer Epidermal Growth Factor Receptor (EGFR) Gefitinib, erlotinib, afatinib [1,23,158-165]
Non-small cell lung cancer Anaplastic Lymphoma Kinase (ALK) inhibitors Crizotinib [91,163,166,167]
Chronic myeloid leukemia Philadelphia chromosome levels Imatinib, nilotinib, dasatinib [168,169]
CCR5-tropic HIV CXCR4, CCR5 receptors Maraviroc [170]
Cystic fibrosis G551D mutation Ivacaftor [88]

Godman et al.

Godman et al. BMC Medicine 2013 11:179   doi:10.1186/1741-7015-11-179

Open Data