Table 1

Number of VDR binding sites
Sample/group 25-OH D Total Downstream Exons Intergenic Introns Up and downstream Upstream UTR
Number %
High 25-hydroxyvitamin D ≥75 13,054 5.3 4.0 32.8 28.4 4.7 14.6 10.2
Low 25-hydroxyvitamin D <75 1,526 3.7 4.8 36.5 18.6 4.3 18.8 13.3
1_VDR 80 3,073 5.2 3.9 37.9 24.0 4.7 13.8 10.5
2_VDR 107 7,118 5.6 4.5 28.2 26.3 5.1 17.0 13.2
3_VDR 76 5,290 5.4 3.5 36.8 29.1 4.1 12.9 8.3
4_VDR 85 3,059 5.1 4.0 37.3 22.3 4.7 15.6 11.0
5_VDR 75 4,051 4.6 4.8 33.0 21.5 5.3 18.8 12.1
HB 29 1,021 3.5 5.7 27.4 16.9 5.6 24.1 17.0
PD 32 200 1.0 3.0 61.7 21.4 0.5 7.0 5.5
SP 34 610 3.2 4.5 38.7 18.8 3.7 18.3 13.0
SR 22 573 3.5 4.9 39.7 17.7 4.0 18.5 11.7
r 0.92 0.82 −0.22 −0.40 0.79 0.44 −0.14 −0.05
P 0.0005 0.0068 0.5746 0.2822 0.0115 0.2401 0.7163 0.891

The number of VDR binding sites at FDR <0.1%. 25-hydroxyvitamin D (25(OH)D) levels are shown in nM. Correlations are shown between 25(OH)D and the number of binding sites. VDR, vitamin D receptor.

Handel et al.

Handel et al. BMC Medicine 2013 11:163   doi:10.1186/1741-7015-11-163

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