Genomic regions of VDR binding sites. The midpoints of each VDR ChIP-seq peak is shown for (A) samples with 25-hydroxyvitamin D ≥75 nM and (B) samples with 25-hydroxyvitamin D <75 nM. Up-, down- and up and downsteam are VDR binding sites within 5 kb of the nearest gene. Numbers show percentages of binding sites within each genomic region. ChIP-seq, chromatin immunoprecipitation and massively parallel sequencing; VDR, vitamin D receptor.
Handel et al. BMC Medicine 2013 11:163 doi:10.1186/1741-7015-11-163