Figure 3.

Analyses of cell size and growth kinetics. The diameter of MSCs from female donors (n = 14) was slightly but significantly smaller compared to male donors (n = 11) (A). The PDT of MSCs from female donors (n = 25) was significantly reduced compared to MSCs from male donors (n = 27) (B). Two-tailed Student’s t-test (*P <0.05). Error bars: SD. The cell diameter correlated positively to the PDT (n = 25) (C). No correlation was found between the donor age and the proliferation capacity of the MSCs (n = 52) (D) and between the donor age to the cell size (n = 25) (E). The specific antibody mediated fluorescence per cell (ΔGeo Mean) of CD105, CD119, CD140a, CD166 and HLA ABC correlated negatively with the cell size (n = 22 except for CD119 (n = 17)) (F-J). The specific antibody mediated fluorescence per cell (ΔGeo Mean) of CD105, CD119, and HLA ABC correlated negatively with the PDT (n = 27 except for CD119 (n = 21)) (K-M). The PDT correlated negatively with the percentage of CD146+ cells within the MSC preparations (n = 27) (N). Spearman two-tailed correlation test (*P <0.05; **P <0.01; ***P <0.001; ****P <0.0001).

Siegel et al. BMC Medicine 2013 11:146   doi:10.1186/1741-7015-11-146
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