Table 1

Differences in clinical efficacy of antihypertensive drugs in ancestry groups
Systolic/diastolic blood pressure reduction*
Drug category European ancestry African ancestry Difference
Calcium blockers 15.3/12.6 16.9/13.3 2.4/0.6
(14.7, 15.9)/(12.3, 12.9) (16.0, 17.7)/(12.9, 13.8) (3.4, 1.3)/(1.2, 0.0)
Diuretics 11.5/9.1 15.0/10.7 3.5/1.5
(9.5, 13.4)/(8.1, 10.1) (13.1, 17.0)/(9.5, 11.9) (6.4, 0.5)/(3.1, −0.1)
ACE-i 12.8/11.4 8.5/8.0 −4.6/−3.0
(11.7, 13.9)/(10.8, 12.0) (7.0, 9.9)/(7.1, 8.9) (−2.7, −6.5)/(−1.9, −4.1)
β-Blockers 11.7/11.3 5.9/9.5 −6.0/−2.9
(10.2, 13.3)/(10.5, 12.1) (4.2, 7.6)/(8.5, 10.4) (−3.6, −8.3)/(−1.6,−4.2)

Legend: Data depicted are pooled estimates (95% confidence intervals) from systematic reviews [3,7]. ACE-i, angiotensin converting enzyme inhibitors. *Mean blood pressure reduction (mm Hg). The depicted difference is the weighted pooled difference in response between ancestry groups, with positive values indicating a greater response in patients of African ancestry and negative values indicating a greater response in patients of European ancestry.

Brewster and Seedat

Brewster and Seedat BMC Medicine 2013 11:141   doi:10.1186/1741-7015-11-141

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