Figure 1.

A clinical staging model for post-pubertal onset and course of major mental disorders: developmental, circadian or anxiety pathophysiological pathways progress from non-specific to discrete syndromes. *Not necessarily a Diagnostic and Statistical Manual for Mental Disorders, fourth edition, or International Classification of Diseases - 10th revision diagnosis; GM: gray matter; WM: white matter.

Hickie et al. BMC Medicine 2013 11:125   doi:10.1186/1741-7015-11-125
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