This article is part of the series Towards a new psychiatry: Philosophical and ethical issues in classification, diagnosis and care.

This article is part of the series Current Controversies in Psychiatry.

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Clinical classification in mental health at the cross-roads: which direction next?

Ian B Hickie1*, Jan Scott234, Daniel F Hermens1, Elizabeth M Scott15, Sharon L Naismith1, Adam J Guastella1, Nick Glozier1 and Patrick D McGorry67

Author Affiliations

1 Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, 2050, Australia

2 Academic Psychiatry, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK

3 FondaMental Foundation, Fondation de Coopération Scientifique Hôpital A. Chenevier, 40 Rue de Mesly, Creteil, F-94000, France

4 INSERM, U 955, IMRB, Psychiatry Genetic, Creteil, F-94000, France

5 School of Medicine, The University of Notre Dame, 160 Oxford Street, Darlinghurst, Sydney, 2010, Australia

6 Centre for Youth Mental Health, University of Melbourne, 35 Poplar Road, Parkville, 3052, Australia

7 Orygen Youth Health Research Centre, Department of Psychiatry, University of Melbourne, 35 Poplar Road, Parkville, 3052, Australia

For all author emails, please log on.

BMC Medicine 2013, 11:125  doi:10.1186/1741-7015-11-125

The electronic version of this article is the complete one and can be found online at:

Received:25 July 2012
Accepted:18 December 2012
Published:14 May 2013

© 2013 Hickie et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.



After 30 years of consensus-derived diagnostic categories in mental health, it is time to head in new directions. Those categories placed great emphasis on enhanced reliability and the capacity to identify them via standardized checklists. Although this enhanced epidemiology and health services planning, it failed to link broad diagnostic groupings to underlying pathophysiology or specific treatment response.


It is time to adopt new goals that prioritize the validation of clinical entities and foster alternative strategies to support those goals. The value of new dimensions (notably clinical staging), that are both clinically relevant and directly related to emerging developmental and neurobiological research, is proposed. A strong emphasis on ‘reverse translation’ (that is, working back from the clinic to the laboratory) underpins these novel approaches. However, it relies on using diagnostic groupings that already have strong evidence of links to specific risk factors or patterns of treatment response.


The strategies described abandon the historical divides between clinical neurology, psychiatry and psychology and adopt the promotion of pathways to illness models.

Classification; Clinical staging; Mental health


Globally, the biggest challenge in public mental health is implementing strategies to reduce the societal burden of mental disorders [1,2]. For those living with mental illness and their families, the most pressing issues are increasing access to affordable health care, promoting social inclusion, supporting economic productivity and reducing premature mortality [1-4]. From a clinical perspective, our greatest failure has been the lack of development of new or better-targeted treatments, particularly for those with persisting and disabling disorders. Additionally, our inability to predict individual responses to treatments and our failure to intervene early to reduce disability or prevent premature death are notable [5-10].

Despite the degree of public or media attention [11-13], deciding the immediate fate of our major international classification systems is not our most central task. It is timely, however, to reflect on the Diagnostic and Statistical Manual (DSM) for Mental Disorders, fourth edition [14] and the closely related International Classification of Diseases, 10th revision (ICD-10) [15]. The application of these systems has improved the reliability of syndromal (symptom-based) diagnoses as used in psychiatry, but these remain inferior to the evidence-based etiological or pathway models employed for other common medical conditions.

After 30 years of clinical research, which is based on a common set of principles, our diagnostic entities remain poorly validated. That is, despite the research explosion in basic neuroscience, imaging and molecular genetics, our categories do not link strongly to any specific neurobiological or environmental risk factors, underlying pathophysiological processes, or patterns of specific treatment response [5,6,16-18]. Consequently, our classification systems have arrived at a fundamental cross-road.

While the DSM processes seem set to continue down familiar paths [19], it is timely to consider whether clinical psychiatry and psychology would be better served by heading in somewhat different directions [20-26]. Here, we explore specific alternatives including a much greater fusion of classification systems with other areas of clinical neuroscience, the use of dimensional measures of behavioral and cognitive change, the adoption of a limited number of pathophysiologically based syndromes that incorporate objective testing, a greater reliance on implications of response to specific treatments, and the extent to which incorporation of a common general medical concept - namely, clinical staging - represents a major advance [27,28]. Most importantly, we suggest that such alternatives take us a much greater way along the path to enhanced treatment planning.

The clinical challenge

It is frustrating that diagnoses are based largely on descriptive phenomena. Often they vary from practitioner to practitioner, and may well change markedly over the course of illness (for example, non-psychotic to psychotic syndrome or unipolar to bipolar mood disorder). As diagnoses are made at non-specific time points along complex illness pathways that evolve from risk to onset and progression to chronic ill-health, they often relate poorly to the actual stage of illness. For the major anxiety, mood or psychotic disorders, the illness process typically has its onset in late childhood or early puberty and then recurs or continues progressively into adult life [29-31]. Although 75% of major mental disorders begin before the age of 25 years [32], our diagnostic criteria are derived largely from the experiences reported by middle-aged persons with established illness. These phenotypes often map poorly onto earlier and often less specific phases of the illness experience [22,25,33,34].

The current systems also assume the concept of multiple parallel pathways each leading to distinct diagnostic categories - an assumption that is not readily supported by modern family, genetic and neurobiological risk factor studies [20,35,36]. Criterion-based symptom sets (which then give rise to specific and ‘independent’ categories) prioritize phenomena such as delusions, hallucinations, periods of elevated mood or increased energy, psychomotor slowing, emotional blunting, or cognitive slowing for disorders such as schizophrenia, bipolar disorder or severe depression. Data from recent community studies that assess patients longitudinally from childhood or adolescence [29,37-39], however, emphasize the extent to which many of these phenomena are shared across disorders [40]. Prototypically, anxiety disorders that are evident in children before the age of 12 years predict later depressive, bipolar and psychotic disorders [41].

With regards to adult-type disorders, persistence or recurrence of symptoms appears to have greater predictive significance than cross-sectional observation of specific symptoms [39,42-45]. Hence, the great clinical challenge is to derive new diagnostic systems that are not only consistent with developmental epidemiology and neurobiology but also useful when applied in everyday clinical practice.

A historical perspective

The great virtue of the research-based classification systems of the late 1970s was that they promoted the pursuit of reliable diagnoses. To achieve diagnostic reliability, a small number of dimensions in human behavior (for example, anxiety, depression, impaired cognition or psychotic phenomena) were organized into a large number of discrete and separate ‘disorders’ - on the basis of the presence or absence of set numbers of key symptoms. Inevitably, this gave rise to a checklist approach to diagnostic practice and the proliferation of diagnostic ‘categories’.

However, reliability was oversold as the necessary precursor to validation of those entities [16]. While the ‘atheoretical’ and reliability-driven approach of DSM-III did set clinical research free from the previous psychological, behavioral or medical models, it did not result in a new era of preventive and therapeutic strategies. In retrospect, it appears that the DSM-III-derived disorders or independent categories relied too heavily on descriptive psychopathology, historical practice or clinical consensus [46,47].

The post-DSM-III era did enhance our capacity to conduct large, multi-site and international research and ensured that diagnostic concepts were less constrained by local history, culture, religion or social customs, or fashion. Such aspirations were essential to promoting the international ‘science’ base of clinical psychiatry and psychology and for forging links to key areas of emerging neuroscience, especially molecular genetics and neuroimaging. Further, this greatly assisted the move away from highly idiosyncratic practice or ‘diagnostic systems’ that were used to prop up the delivery of poorly evaluated (or intrinsically harmful or discriminatory) forms of mental health care. Mental health practice is one area of social endeavor that has benefited greatly from globalization and greater transparency, communication and scrutiny [2].

When linked to national epidemiological surveys, the international classification systems have underpinned more accurate estimates of relative disease burden, access to care and impacts of mental disorders on broader health and social systems [1,32,48]. This has led to more forward thinking about how to best support broad social settings that enhance mental health and wellbeing [49]. Thus, in many ways, the great successes of the post-DSM-III diagnostic era are in public health and related health system developments. It is rather frustrating that, despite the best efforts of scientists and practitioners, the stated aims of advancing clinical research have not been so successful.


Setting new goals for international classification systems

Given the relative failure to validate the DSM- or ICD-derived categories, it is time to set new goals (Table 1) - and propose a range of possible, and rather diverse, strategies to support those goals (Table 2). An over-riding concern in mental health has become the reduction of the population-health burden by adoption of various early intervention strategies [28,50,51]. These focus clinical service development and related research on identifying early forms of illness not only to reduce current morbidity but also to prevent progression to more severe or chronic illness types and associated role impairment [52-57]. Although the fundamental empirical work in this area has focused largely on psychotic disorders, there is now a much broader clinical database emerging that is targeted at the early phases of the more prevalent anxiety and depressive disorders [22,53,58-61].

Table 1. New goals for enhanced diagnostic categories and worked examples for major depression

Table 2. New strategies for deriving diagnostic categories and worked examples for major depression

This movement is similar in conceptualization with that being promoted in other related clinical areas of medicine that have very large impacts on current and future health costs, notably diabetes and related metabolic syndromes [125-127]. As with the move to define pre-diabetes (an intermediate state between normal and clearly raised blood glucose concentrations), it is entirely possible to define emerging mental disorders by their intermediate symptom levels, impacts on function, patterns of persistence over time or predictive capacity [21,22,56,57]. Further, it is possible to design new health care platforms to increase the access to care for young people presenting with these conditions [53,55].

Importantly, the same types of concerns arise in the arenas for both pre-diabetes and early intervention in mental health [51,128]. That is, as the number of individuals identified by health systems grows, and those with less severe forms come into active clinical care, the extent to which early forms of illness can be effectively managed largely by non-pharmacological or other lifestyle-based approaches is a key consideration [66,129,130]. Critics of this area [11,131] all too readily see an over-medicalization or a pharmaceutical-industry-driven conspiracy to be at the heart of such genuine public health movements. Yet the evidence from the clinical staging of ischemic heart disease largely demonstrates the opposite. The greatest public health emphasis was placed on reducing smoking rates, promoting exercise and addressing other modifiable risks. High cost, high risk interventions (for example, revascularization) were reserved for those experiencing major events (for example, first myocardial infarct), those with recurring episodes (for example, coronary by-pass surgery), or following a progression to chronic disease (for example, pharmacotherapy of heart failure) [132,133].

Currently, the key difference between the diabetes and early mental disorder arenas is the extent to which the diagnosis of the ‘at-risk’ or ‘prodromal’ state for diabetes relies on an independent laboratory test - and the extent to which that laboratory test has predictive value for later poor health outcomes. Therefore, concurrently with the development and evaluation of earlier diagnostic thresholds based on descriptive phenomena and related disability estimates [22,52,53], we must intensify our search for better neuropsychological, brain imaging, circadian, neurophysiological, immune or other markers of these early states [58,59,72,76,99,106,134-136] and design studies to test their predictive capacity.

These new goals respond directly to the challenges posed by novel preventive and longitudinal approaches that are targeted at the recognition of early phenotypes. For example, for depressive disorders, there is international recognition that the extraordinary premature death and disability costs attributable to these conditions [48,137] reflect their early age-of-onset, high current and lifetime population prevalence, typical illness patterns of recurrence and chronicity, and likely comorbidity with alcohol and other substance misuse as well as physical ill-health, most notably in the form of premature cardiovascular disease [90,107,138-141]. The ways in which incorporating these new goals might impact on the classification of depressive disorders is outlined here (see Table 1).

As importantly, it is necessary to state those factors which are not the primary goals of a clinical or research classification system. These include: categorizing all forms of abnormal perception, mood, cognition or other behavioral disturbance; imposing independent category status on disturbances that are fundamentally dimensional in nature and frequently inter-correlated (see common forms of anxiety and depression [142,143]); creating diagnostic hierarchies that presume etiological or pathophysiological dominance of one form of disturbance over another (for example, psychotic compared with mood or cognitive phenomena); or using the classification system as the sole basis for allocating research funds, licensing treatments, providing access to health care, determining legal matters, reimbursing health care costs or supporting access to other personal entitlements system.

Contrary to prevailing wisdom, there is no urgent need to have one over-arching international diagnostic system or bible for all perceptual, mood, cognitive and other behavioral syndromes. Unfortunately, the recent attempts to include all things within the one descriptive system have underpinned a rather unhelpful debate about the inclusion or exclusion of fewer or more categories [11,12,144]. Another unintended side-effect of the forced international orthodoxy was the lack of support of other plausible models or active support for the development of alternative approaches [13,16,145].

An emerging body of work, utilizing appropriate genetic modeling and brain imaging data provides provisional support for such alternative approaches [20]. These data favor a model in which mental disorders represent broad patterns of psychopathology. Within this model, various genetic and environmental factors determine the development of common brain circuits that underpin normal behavior and cognition. When perturbed, changes in the function of these circuits give rise to deviant behavior or cognitive function. This model has influenced the National Institutes of Mental Health, which now actively promotes investigation of brain-circuit-based approaches and proposes that they may underpin a new approach to the classification of common mental disorders [20,146].

Within the circuitry models, changes from normal function (thereby giving rise to disorders) are by their nature dimensional rather than categorical. Generally, correlations exist between the degree of accumulated dysfunction of the underlying circuits (or related systems) and the extent of behavioral or cognitive change. This dimensional approach shifts the emphasis from making a specific diagnosis to determining the current level of cognitive or behavioral change in individual patients. Clinical and related neurobiological research then examines the extent to which common risk variables (for example, developmental delay, trait neurocognitive impairments, alcohol or other substance misuse) increase risk to measured behavioral or cognitive change, increase risk to markers of brain impairment (for example, poor neuropsychological function, excessive cortical thinning, disturbed neurophysiological markers) or increase risk to poor outcomes - independently of any specific relationship with classical ‘diagnostic’ entities [108,147,148].

Core dimensions of cognition and behavior are hypothesized to be common to all persons and not viewed as a unique set of characteristics occurring only in those who present with mental health problems. Perturbations of brain circuits will typically result in ‘trans-diagnostic’ rather than pathognomonic symptom sets. An important prediction of such systems is that many objective measures of the structure (for example, brain imaging) or outputs of such systems (for example, cognition - including traditional neuropsychological and social cognition, circadian, hypothalamus-pituitary-adrenal axis function, neurophysiological or immune) will also show little diagnostic specificity. Over the last 30 years, this has been the overwhelming experience with proposed diagnostic markers, such as the dexamethasone suppression test for major depression [149]. Preliminary analyses of data from those in the early phases of a range of major psychotic or mood disorders also support this perspective [58-61,72,73,76,99,106,136,150],[151].

New strategies for enhancing the diagnoses of perceptual, mood, cognitive and other behavioral syndromes

A range of diverse strategies can be advanced to support these new goals (see Table 2). These do not need to come together into one single bible for clinical or research purposes, as the initial aim is to develop, evaluate and refine them frequently as evidence emerges. A potential consequence of the key shift from many categories to the use of fewer underlying dimensions is that it is likely to lead to the need for an alternative term to mental disorders. A very broad descriptive concept that encapsulates a 21st century approach to disturbances of perception, mood, cognition and other behavioral dimensions may be required. The clear public, professional, clinical and research benefits likely to derive from abandoning the historical and cultural divisions between clinical neurology and psychiatry and clinical psychology have been highlighted by others [13,26].

In doing so, such strategies move away from the very broad categories we currently use (for example, major depression) to describe very heterogeneous populations. Generally, more specific states (for example, depression in association with late-life vascular disease; first episode psychosis; cannabis-associated recurrence of psychosis; depressive episode following previous manic episode) provide a better fit with known risk factors, actual pathophysiology or known illness course and may be much more useful in research and some fields of clinical practice [83].

In association with all disorders, more general age-of-onset and stage-of-illness concepts should be recorded. Those that have clear pathways to illness need to be emphasized (for example, childhood attention deficit hyperactivity disorder leading to early age of onset of substance misuse; childhood schizotypal or autistic behaviors leading to early onset psychotic disorder; adolescent social anxiety leading to alcohol misuse). Concurrently, this may help to reduce the overuse of the concept of comorbidity - limiting it in the future to the co-occurrence of genuinely independent conditions (for example, psychotic disorder and alcohol dependence).

It is clear that one of the most robust ways of differentiating diagnostic groups is on the basis of response (or non-response) to specific treatments. Much greater effort needs to be invested in the reverse translation agenda (that is, working back from the bedside to the bench). For example, we urgently need to unravel what neurobiological factors differentiate those with schizophrenia who respond to clozapine or those with bipolar disorder who respond to lithium. The goal is to develop better predictors of treatment-response before initiating therapies.

At this time, we argue that we may be better served by investing heavily in a much smaller number of more discrete syndromes that are partially validated by clinical course, objective markers or predictors of treatment response. That is, rather than prioritize reliability, we could vigorously pursue those more homogeneous groups that are identified in clinical practice or family studies [90-93]. Inevitably, this would advance the push for more personalized approaches to health care. Further, relevant groups could be preferentially recruited to specific preventive or treatment trials (for example, late-onset depression; childhood-onset obsessive-compulsive disorder; psychotic disorder preceded by childhood schizotypal behaviors; first-episode mania; depressive disorders characterized by disturbed hypothalamic-pituitary function, circadian disruption or immune activation).

Another clear way of approaching this desire for greater specificity is to focus on syndromes that are closely linked with discrete environmental exposures, social adversity or inter-current medical events [152]. These natural experiments can be used to facilitate more targeted pathophysiological studies (for example, post-infective or post-stroke neuropsychiatric syndromes; post-traumatic depressive states; depression or prolonged fatigue states following cancer therapies; alcohol or other substance misuse neuropsychiatric syndromes; cannabis-associated first episode of psychosis [89,153-156]).

We would also promote an overt move away from checklist-driven criteria that rely on poorly validated symptom sets (for example, treating independent symptoms such as sleep disturbance and suicidal ideation as equivalent items for the diagnosis of major depressive disorders). Instead, we favor a move back towards clear syndromes that share key pathophysiological, symptom or illness course features (for example, psychotic depression; melancholic disorders that are associated with concurrent psychomotor change; first-episode psychosis; bipolar disorder diagnosed by a discrete manic episode). This process would also be assisted by greater use of objective markers of key features of disorders (for example, computer-generated measures of neurocognitive function; actigraphy-generated measures of sleep-wake cycle; self-report based measures of cognitive styles) and wider use of clinician or self-reported measures of key symptom dimensions.

Promoting the use of clinical staging

One of the most important developments in recent years has been the importing of the concept of clinical staging from general medicine. In other clinical domains (for example, oncology, coronary heart disease, inflammatory join disease), it is totally inadequate to choose treatments, or plan health care, for persons who suffer from recurring or progressive conditions simply on the basis of a broad diagnostic category (for example, breast cancer). We suggest that it is equally meaningless in mental health to select specific treatments on the basis of broad categories such as schizophrenia, bipolar disorder or major depression. There is a wealth of evidence indicating that patients at different points along the illness continuum of all of these conditions show quite different patterns of response to various interventions [21,88,157,158].

Consequently, we have proposed a general framework for clinical staging that can be applied to the more severe mood or psychotic disorders (Figure 1). This framework is readily applied to those who present for health care and clearly differentiates those in early phases (stages 1a ‘seeking help’ or 1b ‘attenuated syndromes’) from those who have reached a higher threshold for disorder (stage 2 and above - see Figure 1). Current clinical and related neurobiological studies (for example, magnetic resonance imaging; neuropsychological and sleep/circadian studies) of this framework provide provisional evidence in support of its reliability and validity [22,58,59].

thumbnailFigure 1. A clinical staging model for post-pubertal onset and course of major mental disorders: developmental, circadian or anxiety pathophysiological pathways progress from non-specific to discrete syndromes. *Not necessarily a Diagnostic and Statistical Manual for Mental Disorders, fourth edition, or International Classification of Diseases - 10th revision diagnosis; GM: gray matter; WM: white matter.

As compared with current DSM and ICD disorder thresholds, and particularly for the common anxiety and depressive disorders, this approach raises the bar for the initiation of more specific or intensive pharmacological or behavioral strategies. That is, although this approach does encourage more active health care for those at lower levels of illness, it also promotes the use of safe, easily-delivered and non-specific psychological intervention, health-care, suicide prevention and other secondary prevention strategies for those who have not yet reached the higher threshold for a stage 2 disorder [54,84].

Likely benefits of developing multiple diagnostic dimensions and linking these to clinical staging

All of these strategies move the emphasis from the rather sterile academic debates about the virtues of competing symptom sets (or illness thresholds) [159-161] to the provision of relevant treatment at key points along an illness path. In dialogue with individual patients, this would result in the provision of far more accurate, multi-dimensional and context-relevant information. In our view, stating clearly that a 21-year-old man has a first-onset psychosis, with a strong family history of mania and associated five-year history of persistent cannabis use is more likely to guide treatment selection, health care planning and accurate prognostic statements than assigning any of the current psychosis disorder categories. Similarly, stating that a 17-year-old girl has the recent onset of a depressive disorder characterized by psychomotor slowing and preceded by prolonged fatigue, seasonal changes in mood and energy, with no evidence of childhood anxiety or concurrent alcohol or substance misuse is more useful than attaching any of the current depression categories. While these approaches are already common in everyday clinical practice they are not captured in our current diagnostic systems.

Further, we need systems that support innovative research paradigms such as those promoted by the youth mental health for common mental disorders and early intervention in psychosis movements [162,163]. Within these novel paradigms, it is far more important to recruit patients who share key demographic, illness stage, prior treatment characteristics or family history (for example, age, gender, duration of illness, lack of prior exposure to medical treatments, family history of psychosis or mania) rather than pre-selecting on the basis of poorly-validated syndromal constructs such as major depression.

Such novel research paradigms inevitably focus attention on those genetic or environmental risk factors that are common across disorders (and hence may be modified with resulting benefits to a large number of persons), distinct from the narrow search for unique risk factors that link specifically to each separate disorder. Key considerations such as the role of intra-uterine environments, early childhood infections, childhood sexual or emotional abuse, early adolescent alcohol or substance misuse, grossly distorted adolescent sleep patterns, and physical inactivity in the teenage years will then emerge as major foci for targeted research and potential public health programs [58,60,108,164-166].

Implications for clinical research and reverse translation

These alternative approaches to classification would give rise to a new wave of early intervention, biomarker, clinical intervention and other longitudinal studies. Specifically, they would also promote reverse translation initiatives - meaning those research programs that work back from clinical research based on well-characterized, more narrow and probably more homogeneous patient groups to elucidate more fundamental biological correlates. Additionally, the reverse translation agenda has other important attributes, including actively responding to topics of real significance to those living with the illness (for example, cognitive impairment in those with psychotic disorders) and capitalizing on phenomena that have been well-replicated in studies on humans (for example, lithium-responsive bipolar disorder or clozapine-responsive schizophrenia).

The combination of key clinical insights and patient priorities plays a crucial role in setting the reverse translation research agenda [2]. Categories deserving of detailed neurobiological research are those clinical situations in which a robust link with relevant pathophysiological, risk, illness-stage or treatment variables has already been demonstrated (for example, circadian-based depressive disorders - see Table 3; cannabis-associated psychosis; first-episode mania; or clozapine-responsive schizophrenia disorders).

Table 3. Reverse translation research agenda for circadian-based mood disorders

On the basis of making new links in these smaller but clinically-defined cohorts with the best available markers of the active pathophysiology, we would then expect new insights that could provide a basis for working forwards again (that is, bench back to bedside). A new wave of more relevant animal models, molecular targeting or other rapid assay modalities could emerge. The goal then is to use that new knowledge to implement better targeted and more individualized prevention or active treatment strategies (that is, traditional forward translation programs [167,186-188]). Such translational research programs (that is, those that incorporate both reverse and forward strategies) would then genuinely link 21st century neurobiology to clinical practice in an iterative and mutually-informative discourse.

The impact of the move away from investigating traditional schizophrenia to more focused first-episode psychosis (and then related prodromal or at-risk clinical research) in Australia, Europe and the United Kingdom demonstrates the extent to which these novel approaches can genuinely transform clinical practice [27,56,163]. By contrast, those working in the anxiety and mood disorders fields have been slow to comprehend the significance of these developments [28,85]. We believe the time is now right for a more general shift in direction in favor of those diagnostic practices that focus attention on key developmental, illness course, reverse translation and strategic intervention approaches. Although we can recognize the genuine progress that the DSM and ICD revisions from 1980 onwards supported, there is now no longer any good reason for the international mental health community to be constrained by the ongoing revisions of these systems.


After 30 years of consensus-based diagnostic categories in mental health, there is great clinical and public frustration with our relative failure to deliver real clinical advances. The approach introduced by the DSM-III (1980) prioritized reliability and imposed a categorical approach on many underlying dimensions of abnormal cognition, mood or behavior. It also sought to ‘cover the field’ and in doing so gave rise to new entities for further research and evaluation. The general approach enhanced epidemiology, international collaboration and health services planning, but too little progress has been made with linking the multiple broad entities to clear genetic or environmental risk factors, underlying pathophysiology or specific patterns of treatment response. Consequently, we have argued that it is time to prioritize the validation of more robust clinical entities and foster the development of specific strategies to support this priority. The proposed goals put enhanced clinical practice back at the center of the endeavor, work with strong cross-sectional and longitudinal epidemiological, family and twin studies, and use available objective markers. The value of implementing new dimensions, notably clinical staging, that are both clinically relevant and directly related to emerging epidemiological, developmental and neurobiological research is also proposed. The strategies described abandon the historical and cultural divides between clinical neurology, psychiatry and psychology and actively move away from broad descriptive terms (for example, major depression, schizophrenia, bipolar disorder) to the promotion of pathways to illness models. These models incorporate age-of-onset, known environmental risk factors and patterns of response to specific treatments (for example, lithium-responsive bipolar disorder, clozapine-responsive psychosis). A strong emphasis on a reverse translation agenda (that is, working back from the clinic to the laboratory) is highlighted. This agenda relies on using diagnostic groupings that already have strong evidence of links to specific risk factors or patterns of treatment response. We have detailed the ways in which these approaches could enhance clinical practice in the most impactful of the major mental disorders, namely major depression. In this worked example, the term major depression would largely be replaced by much more specific terms that differentiate early- from late-onset, those presentations that fundamentally followed-on from childhood anxiety and those disorders that were strongly linked with objective measures of circadian disturbance. As with all other disorders, clinical staging of depressive disorders would also clearly differentiate early-attenuated forms from first major episodes of illness (both typically occurring in adolescence or early adult years) and later recurrent, persistent or chronic forms.


DSM: Diagnostic and Statistical Manual of Mental Disorders; ICD: International Classification of Diseases.

Competing interests

IBH was a director of headspace: the national youth mental health foundation until January 2012. He is the executive director of the Brain and Mind Research Institute (BMRI), which operates two early-intervention youth services under contract to headspace. He is a member of the new Australian National Mental Health commission and was previously the CEO of beyondblue: the national depression initiative. He has led a range of community-based and pharmaceutical industry-supported depression awareness and education and training programs. He has led depression and other mental health research projects that have been supported by a variety of pharmaceutical partners. Current investigator-initiated studies are supported by Servier and Pfizer. He has received honoraria for his contributions to professional educational seminars related to depression, youth mental health and circadian-rhythms research. DFH has received honoraria for educational seminars from Janssen-Cilag. EMS is the (unpaid) Clinical Director of Headspace Services at the BMRI, the (unpaid) Coordinator of the Youth Mental Health Research Program at the BMRI, and Deputy Director of St Vincent’s Private Hospital Young Adult Mental Health Unit. She has received honoraria for educational seminars related to the clinical management of depressive disorders supported by Servier and Eli Lilly pharmaceuticals. She has participated in a national advisory board for the antidepressant compound Pristiq, manufactured by Pfizer. PDM is director of headspace and also of Headstrong (Irish National YMH Foundation) and he holds Investigator Initiated Research Grant Support from Janssen Cilag, Eli Lilly, BMS and Astra Zeneca. PDM also has consultancy and advisory roles with Janssen Cilag, Eli Lilly, BMS, AZ Roche and Pfizer.

Authors’ contributions

All authors discussed the evidence and contributed to the writing of this manuscript, primarily through a significant discourse undertaken over the past five years. All authors read and approved the final manuscript.


IBH, DFH and AJG are supported by an NHMRC Australia Fellowship awarded to IBH (464914). SLN is funded by an NHMRC Clinical Research Fellowship (402864). This work was further supported by NHMRC Program Grant (566529).


  1. Gustavsson A, Svensson M, Jacobi F, Allgulander C, Alonso J, Beghi E, Dodel R, Ekman M, Faravelli C, Fratiglioni L, Gannon B, Jones DH, Jennum P, Jordanova A, Jonsson L, Karampampa K, Knapp M, Kobelt G, Kurth T, Lieb R, Linde M, Ljungcrantz C, Maercker A, Melin B, Moscarelli M, Musayev A, Norwood F, Preisig M, Pugliatti M, Rehm J5: Cost of disorders of the brain in Europe 2010.

    Eur Neuropsychopharmacol 2011, 21:718-779. PubMed Abstract | Publisher Full Text OpenURL

  2. Collins PY, Patel V, Joestl SS, March D, Insel TR, Daar AS, Bordin IA, Costello EJ, Durkin M, Fairburn C, Glass RI, Hall W, Huang Y, Hyman SE, Jamison K, Kaaya S, Kapur S, Kleinman A, Ogunniyi A, Otero-Ojeda A, Poo M-M, Ravindranath V, Sahakian BJ, Saxena S, Singer PA, Stein DJ, Anderson W, Dhansay MA, Ewart W, Phillips A: Grand challenges in global mental health.

    Nature 2011, 475:27-30. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  3. Hickie IB, Groom GL, McGorry PD, Davenport TA, Luscombe GM: Australian mental health reform: time for real outcomes.

    Med J Aust 2005, 182:401-406. PubMed Abstract | Publisher Full Text OpenURL

  4. Mental Health Council of Australia: Not For Service: Experiences of Injustice and Despair in Mental Health Care in Australia. Canberra: Mental Health Council of Australia; 2005. OpenURL

  5. Insel TR, Sahakian BJ: Drug research: a plan for mental illness.

    Nature 2012, 483:269-269. PubMed Abstract | Publisher Full Text OpenURL

  6. Hyman SE: A glimmer of light for neuropsychiatric disorders.

    Nature 2008, 455:890-893. PubMed Abstract | Publisher Full Text OpenURL

  7. Amara SG, Grillner S, Insel T, Nutt D, Tsumoto T: Neuroscience in recession?

    Nat Rev Neurosci 2011, 12:297-302. PubMed Abstract | Publisher Full Text OpenURL

  8. Insel TR: Rethinking schizophrenia.

    Nature 2010, 468:187-193. PubMed Abstract | Publisher Full Text OpenURL

  9. Wang PS, Insel TR: NIMH-Funded Pragmatic Trials: moving on.

    Neuropsychopharmacology 2010, 35:2489-2490. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  10. Morris SE, Insel TR: Reconceptualizing schizophrenia.

    Schizophr Res 2011, 127:1-2. PubMed Abstract | Publisher Full Text OpenURL

  11. Diagnosing the D.S.M.

    [ webcite]


  12. Psychiatry’s bible, the DSM, is doing more harm than good.

    [ webcite]

    PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  13. The Lancet: Psychiatry’s identity crisis.

    Lancet 2012, 379:1274. PubMed Abstract | Publisher Full Text OpenURL

  14. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders. 4th edition. Washington DC: American Psychiatric Association; 2000.

    Text Revision


  15. World Health Organization: ICD-10 Classifications of Mental and Behavioural Disorder: Clinical Descriptions and Diagnostic Guidelines. Geneva: World Health Organization; 1992. OpenURL

  16. Hyman SE: The diagnosis of mental disorders: the problem of reification.

    Annu Rev Clin Psychol 2010, 6:155-179. PubMed Abstract | Publisher Full Text OpenURL

  17. Hyman SE: Can neuroscience be integrated into the DSM-V?

    Nat Rev Neurosci 2007, 8:725-732. PubMed Abstract | Publisher Full Text OpenURL

  18. Wray NR, Pergadia ML, Blackwood DHR, Penninx BWJH, Gordon SD, Nyholt DR, Ripke S, MacIntyre DJ, McGhee KA, Maclean AW, Smit JH, Hottenga JJ, Willemsen G, Middeldorp CM, de Geus EJC, Lewis CM, McGuffin P, Hickie IB, van den Oord EJCG, Liu JZ, Macgregor S, McEvoy BP, Byrne EM, Medland SE, Statham DJ, Henders AK, Heath AC, Montgomery GW, Martin NG, Boomsma DI: Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned.

    Mol Psychiatry 2010, 17:36-48. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  19. DSM-5: The Future of Psychiatric Diagnosis.

    [ webcite]


  20. Buckholtz JW, Meyer-Lindenberg A: Psychopathology and the human connectome: toward a transdiagnostic model of risk for mental illness.

    Neuron 2012, 74:990-1004. PubMed Abstract | Publisher Full Text OpenURL

  21. McGorry PD, Hickie IB, Yung AR, Pantelis C, Jackson HJ: Clinical staging of psychiatric disorders: a heuristic framework for choosing earlier, safer and more effective interventions.

    Aust N Z J Psychiatry 2006, 40:616-622. PubMed Abstract | Publisher Full Text OpenURL

  22. Hickie IB, Scott EM, Hermens DF, Naismith SL, Guastella AJ, Kaur M, Sidis A, Whitwell B, Glozier N, Pantelis C, Wood SJ, McGorry PD: Applying a clinical staging framework in young people who present with admixtures of anxious, depressive or psychotic symptoms.

    Early Interv Psychiatry 2013, 7:31-43. PubMed Abstract | Publisher Full Text OpenURL

  23. Nesse RM, Stein DJ: Towards a genuinely medical model for psychiatric nosology.

    BMC Med 2012, 10:5. PubMed Abstract | BioMed Central Full Text | PubMed Central Full Text OpenURL

  24. Insel T, Cuthbert B, Garvey M, Heinssen R, Pine DS, Quinn K, Sanislow C, Wang P: Research domain criteria (RDoC): toward a new classification framework for research on mental disorders.

    Am J Psychiatry 2010, 167:748-751. PubMed Abstract | Publisher Full Text OpenURL

  25. McGorry PD: Risk syndromes, clinical staging and DSM V: new diagnostic infrastructure for early intervention in psychiatry.

    Schizophr Res 2010, 120:49-53. PubMed Abstract | Publisher Full Text OpenURL

  26. White PD, Rickards H, Zeman AZJ: Time to end the distinction between mental and neurological illnesses.

    BMJ 2012, 344:e3454. PubMed Abstract | Publisher Full Text OpenURL

  27. McGorry PD: The recognition and optimal management of early psychosis: applying the concept of staging in the treatment of psychosis. In Evolving Psychosis. Edited by Johannessen JO, Martinvale BV, Cullberg J. New York: Routledge/Taylor & Francis Group; 2006. OpenURL

  28. Scott J, Hickie IB, McGorry P: Pre-emptive psychiatric treatments: pipe dream or a realistic outcome of clinical staging models?

    Neuropsychiatry 2012, 2:263-266. Publisher Full Text OpenURL

  29. Merikangas KR, He J-P, Burstein M, Swanson SA, Avenevoli S, Cui L, Benjet C, Georgiades K, Swendsen J: Lifetime prevalence of mental disorders in U.S. adolescents: results from the National Comorbidity Survey Replication Adolescent Supplement (NCS-A).

    J Am Acad Child Adolesc Psychiatry 2010, 49:980-989. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  30. Paus T, Keshavan M, Giedd JN: Why do many psychiatric disorders emerge during adolescence?

    Nat Rev Neurosci 2008, 9:947-957. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  31. Hafner H, An Der Heiden W, Maurer K: Evidence for separate diseases? Stages of one disease or different combinations of symptom dimensions?

    Eur Arch Psychiatry Clin Neurosci 2008, 258 Suppl 2:85-96. PubMed Abstract | Publisher Full Text OpenURL

  32. Gore FM, Bloem PJN, Patton GC, Ferguson J, Joseph V, Coffey C, Sawyer SM, Mathers CD: Global burden of disease in young people aged 10–24 years: a systematic analysis.

    Lancet 2011, 377:2093-2102. PubMed Abstract | Publisher Full Text OpenURL

  33. McGorry PD, Yung AR, Bechdolf A, Amminger P: Back to the future: predicting and reshaping the course of psychotic disorder.

    Arch Gen Psychiatry 2008, 65:25-27. PubMed Abstract | Publisher Full Text OpenURL

  34. McGorry PD: Issues for DSM-V: clinical staging: a heuristic pathway to valid nosology and safer, more effective treatment in psychiatry.

    Am J Psychiatry 2007, 164:859-860. PubMed Abstract | Publisher Full Text OpenURL

  35. Lichtenstein P, Yip BH, Bjork C, Pawitan Y, Cannon TD, Sullivan PF, Hultman CM: Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study.

    Lancet 2009, 373:234-239. PubMed Abstract | Publisher Full Text OpenURL

  36. Sullivan PF, Daly MJ, O’Donovan M: Genetic architectures of psychiatric disorders: the emerging picture and its implications.

    Nat Rev Genet 2012, 13:537-551. PubMed Abstract | Publisher Full Text OpenURL

  37. Merikangas KR, Cui L, Kattan G, Carlson GA, Youngstrom EA, Angst J: Mania with and without depression in a community sample of U.S. adolescents.

    Arch Gen Psychiatry 2012, 69:943-951. PubMed Abstract | Publisher Full Text OpenURL

  38. Merikangas KR, Herrell R, Swendsen J, Rossler W, Ajdacic-Gross V, Angst J: Specificity of bipolar spectrum conditions in the comorbidity of mood and substance use disorders: results from the Zurich cohort study.

    Arch Gen Psychiatry 2008, 65:47-52. PubMed Abstract | Publisher Full Text OpenURL

  39. Kelleher I, Keeley H, Corcoran P, Lynch F, Fitzpatrick C, Devlin N, Molloy C, Roddy S, Clarke MC, Harley M, Arseneault L, Wasserman C, Carli V, Sarchiapone M, Hoven C, Wasserman D, Cannon M: Clinicopathological significance of psychotic experiences in non-psychotic young people: evidence from four population-based studies.

    Br J Psychiatry 2012, 201:26-32. PubMed Abstract | Publisher Full Text OpenURL

  40. Murray GK, Jones PB: Psychotic symptoms in young people without psychotic illness: mechanisms and meaning.

    Br J Psychiatry 2012, 201:4-6. PubMed Abstract | Publisher Full Text OpenURL

  41. Kim-Cohen J, Caspi A, Moffitt TE, Harrington H, Milne BJ, Poulton R: Prior juvenile diagnoses in adults with mental disorder: Developmental follow-back of a prospective-longitudinal cohort.

    Arch Gen Psychiatry 2003, 60:709-717. PubMed Abstract | Publisher Full Text OpenURL

  42. Van Os J, Jones P, Sham P, Bebbington P, Murray RM: Risk factors for onset and persistence of psychosis.

    Soc Psychiatry Psychiatr Epidemiol 1998, 33:596-605. PubMed Abstract | Publisher Full Text OpenURL

  43. Van Os J, Linscott RJ, Myin-Germeys I, Delespaul P, Krabbendam L: A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness-persistence-impairment model of psychotic disorder.

    Psychol Med 2009, 39:179-195. PubMed Abstract | Publisher Full Text OpenURL

  44. Tijssen MJA, van Os J, Wittchen H-U, Lieb R, Beesdo K, Mengelers R, Wichers M: Prediction of transition from common adolescent bipolar experiences to bipolar disorder: 10-year study.

    Br J Psychiatry 2010, 196:102-108. PubMed Abstract | Publisher Full Text OpenURL

  45. Gregory AM, Caspi A, Eley TC, Moffitt TE, O’Connor TG, Poulton R: Prospective longitudinal associations between persistent sleep problems in childhood and anxiety and depression disorders in adulthood.

    J Abnorm Child Psychol 2005, 33:157-163. PubMed Abstract | Publisher Full Text OpenURL

  46. Shorter E: Before Prozac: The Troubled History of Mood Disorders in Psychiatry. New York: Oxford University Press; 2009. OpenURL

  47. Horowitz AV, Wakefield JC: The Loss of Sadness: How Psychiatry Transformed Normal Sorrow into Depressive Disorder. New York: Oxford University Press; 2007. OpenURL

  48. Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJL: Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data.

    Lancet 2006, 367:1747-1757. PubMed Abstract | Publisher Full Text OpenURL

  49. Beddington J, Cooper CL, Field J, Goswami U, Huppert FA, Jenkins R, Jones HS, Kirkwood TBL, Sahakian BJ, Thomas SM: The mental wealth of nations.

    Nature 2008, 455:1057-1060. PubMed Abstract | Publisher Full Text OpenURL

  50. Insel TR: The arrival of preemptive psychiatry.

    Early Interv Psychiatry 2007, 1:5-6. PubMed Abstract | Publisher Full Text OpenURL

  51. McGorry P: Early intervention in psychiatry: the next developmental stage.

    Early Interv Psychiatry 2012, 6:1-2. PubMed Abstract | Publisher Full Text OpenURL

  52. Hamilton BA, Naismith SL, Scott EM, Purcell S, Hickie IB: Disability is already pronounced in young people with early stages of affective disorders: data from an early intervention service.

    J Affect Disord 2011, 131:84-91. PubMed Abstract | Publisher Full Text OpenURL

  53. Scott EM, Hermens DF, Glozier N, Naismith SL, Guastella AJ, Hickie IB: Targeted primary care-based mental health services for young Australians.

    Med J Aust 2012, 196:136-140. PubMed Abstract | Publisher Full Text OpenURL

  54. Scott E, Naismith SL, Whitwell BG, Hamilton B, Chudleigh C, Hickie IB: Delivering youth-specific mental health services: the advantages of a collaborative, multi-disciplinary system.

    Australas Psychiatry 2009, 17:189-194. PubMed Abstract | Publisher Full Text OpenURL

  55. McGorry PD, Tanti C, Stokes R, Hickie IB, Carnell K, Littlefield LK, Moran J: Headspace: Australia’s National Youth Mental Health Foundation - where young minds come first.

    Med J Aust 2007, 187:S68. PubMed Abstract | Publisher Full Text OpenURL

  56. McGorry PD, Killackey E, Yung AR: Early intervention in psychotic disorders: detection and treatment of the first episode and the critical early stages.

    Med J Aust 2007, 187:S8. PubMed Abstract | Publisher Full Text OpenURL

  57. McGorry PD, Yung AR, Phillips LJ: The “close-in” or ultra high-risk model: a safe and effective strategy for research and clinical intervention in prepsychotic mental disorder.

    Schizophr Bull 2003, 29:771-790. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  58. Naismith SL, Hermens DF, Ip TKC, Bolitho S, Scott EM, Rogers NL, Hickie IB: Circadian profiles in young people during the early stages of affective disorder.

    Transl Psychiatry 2012, 2:e123. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  59. Lagopoulos J, Hermens D, Naismith S, Scott E, Hickie I: Frontal lobe changes occur early in the course of affective disorders in young people.

    BMC Psychiatry 2012, 12:4. PubMed Abstract | BioMed Central Full Text | PubMed Central Full Text OpenURL

  60. Robillard R, Naismith SL, Rogers NL, Ip TK, Hermens DF, Scott EM, Hickie IB: Delayed sleep phase in young people with unipolar or bipolar affective disorders.

    J Affect Disord 2013, 145:260-263. PubMed Abstract | Publisher Full Text OpenURL

  61. Scott EM, Hermens DF, Naismith SL, Guastella AJ, De Regt T, White D, Lagopoulos J, Hickie IB: Distinguishing young people with emerging bipolar disorders from those with unipolar depression.

    J Affective Dis 2013, 144:208-215. Publisher Full Text OpenURL

  62. Andrews G, Brugha T, Thase ME, Duffy FF, Rucci P, Slade T: Dimensionality and the category of major depressive episode.

    Int J Methods Psychiatr Res 2007, 16 Suppl 1:S41-S51. PubMed Abstract | Publisher Full Text OpenURL

  63. Parker G, Hadzi-Pavlovic D, Brodaty H, Boyce P, Mitchell P, Wilhelm K, Hickie I, Eyers K: Psychomotor disturbance in depression: defining the constructs.

    J Affect Disord 1993, 27:255-265. PubMed Abstract | Publisher Full Text OpenURL

  64. Hickie I, Parsonage B, Parker G: Prediction of response to electroconvulsive therapy. Preliminary validation of a sign-based typology of depression.

    Br J Psychiatry 1990, 157:65-71. PubMed Abstract | Publisher Full Text OpenURL

  65. Parker G, Hadzi-Pavlovic D, Wilhelm K, Hickie I, Brodaty H, Boyce P, Mitchell P, Eyers K: Defining melancholia: properties of a refined sign-based measure.

    Br J Psychiatry 1994, 164:316-326. PubMed Abstract | Publisher Full Text OpenURL

  66. Hickie IB, Luscombe GM, Davenport TA, Burns JM, Highet NJ: Perspectives of young people on depression: awareness, experiences, attitudes and treatment preferences.

    Early Interv Psychiatry 2007, 1:333-339. PubMed Abstract | Publisher Full Text OpenURL

  67. Hickie I, Koschera A, Hadzi-Pavlovic D, Bennett B, Lloyd A: The temporal stability and co-morbidity of prolonged fatigue: a longitudinal study in primary care.

    Psychol Med 1999, 29:855-861. PubMed Abstract | Publisher Full Text OpenURL

  68. Koschera A, Hickie I, Hadzi-Pavlovic D, Wilson A, Lloyd A: Prolonged fatigue, anxiety and depression: exploring relationships in a primary care sample.

    Aust N Z J Psychiatry 1999, 33:545-552. PubMed Abstract | Publisher Full Text OpenURL

  69. Hickie IB, Koschera A, Davenport TA, Naismith SL, Scott EM: Comorbidity of common mental disorders and alcohol or other substance misuse in Australian general practice.

    Med J Aust 2001, 175(Suppl):S31-S36. PubMed Abstract OpenURL

  70. Carroll BJ: Informed use of the dexamethasone suppression test.

    J Clin Psychiatry 1986, 47:10-12. PubMed Abstract OpenURL

  71. Naismith SL, Rogers NL, Lewis SJG, Terpening Z, Ip T, Diamond K, Norrie L, Hickie IB: Sleep disturbance relates to neuropsychological functioning in late-life depression.

    J Affect Disord 2011, 132:139-145. PubMed Abstract | Publisher Full Text OpenURL

  72. Hermens DF, Redoblado Hodge MA, Naismith SL, Kaur M, Scott E, Hickie IB: Neuropsychological clustering highlights cognitive differences in young people presenting with depressive symptoms.

    J Int Neuropsychol Soc 2011, 17:267-276. PubMed Abstract | Publisher Full Text OpenURL

  73. Hermens DF, Naismith SL, Redoblado Hodge MA, Scott EM, Hickie IB: Impaired verbal memory in young adults with unipolar and bipolar depression.

    Early Interv Psychiatry 2010, 4:227-233. PubMed Abstract | Publisher Full Text OpenURL

  74. Hickie IB, Naismith SL, Ward PB, Little CL, Pearson M, Scott EM, Mitchell P, Wilhelm K, Parker G: Psychomotor slowing in older patients with major depression: relationships with blood flow in the caudate nucleus and white matter lesions.

    Psychiatry Res 2007, 155:211-220. PubMed Abstract | Publisher Full Text OpenURL

  75. Naismith SL, Hickie IB, Turner K, Little CL, Winter V, Ward PB, Wilhelm K, Mitchell P, Parker G: Neuropsychological performance in patients with depression is associated with clinical, etiological and genetic risk factors.

    J Clin Exp Neuropsychol 2003, 25:866-877. PubMed Abstract | Publisher Full Text OpenURL

  76. Hatton SN, Lagopoulos J, Hermens DF, Naismith SL, Bennett MR, Hickie IB: Correlating anterior insula gray matter volume changes in young people with clinical and neurocognitive outcomes: an MRI study.

    BMC Psychiatry 2012, 12:45. PubMed Abstract | BioMed Central Full Text | PubMed Central Full Text OpenURL

  77. Naismith SL, Lagopoulos J, Ward PB, Davey CG, Little C, Hickie IB: Fronto-striatal correlates of impaired implicit sequence learning in major depression: an fMRI study.

    J Affect Disord 2010, 125:256-261. PubMed Abstract | Publisher Full Text OpenURL

  78. Hickie I, Naismith S, Ward PB, Turner K, Scott E, Mitchell P, Wilhelm K, Parker G: Reduced hippocampal volumes and memory loss in patients with early- and late-onset depression.

    Br J Psychiatry 2005, 186:197-202. PubMed Abstract | Publisher Full Text OpenURL

  79. Naismith S, Hickie I, Ward PB, Turner K, Scott E, Little C, Mitchell P, Wilhelm K, Parker G: Caudate nucleus volumes and genetic determinants of homocysteine metabolism in the prediction of psychomotor speed in older persons with depression.

    Am J Psychiatry 2002, 159:2096-2098. PubMed Abstract | Publisher Full Text OpenURL

  80. Hickie I, Ward P, Scott E, Haindl W, Walker B, Dixon J, Turner K: Neo-striatal rCBF correlates of psychomotor slowing in patients with major depression.

    Psychiatry Res 1999, 92:75-81. PubMed Abstract | Publisher Full Text OpenURL

  81. Hickie I, Scott E, Wilhelm K, Brodaty H: Subcortical hyperintensities on magnetic resonance imaging in patients with severe depression–a longitudinal evaluation.

    Biol Psychiatry 1997, 42:367-374. PubMed Abstract | Publisher Full Text OpenURL

  82. Hickie I, Scott E, Mitchell P, Wilhelm K, Austin MP, Bennett B: Subcortical hyperintensities on magnetic resonance imaging: clinical correlates and prognostic significance in patients with severe depression.

    Biol Psychiatry 1995, 37:151-160. PubMed Abstract | Publisher Full Text OpenURL

  83. Naismith SL, Norrie LM, Mowszowski L, Hickie IB: The neurobiology of depression in later-life: clinical, neuropsychological, neuroimaging and pathophysiological features.

    Prog Neurobiol 2012, 98:99-143. PubMed Abstract | Publisher Full Text OpenURL

  84. Hickie IB, Naismith SL, Norrie LM, Scott EM: Managing depression across the life cycle: new strategies for clinicians and their patients.

    Intern Med J 2009, 39:720-727. PubMed Abstract | Publisher Full Text OpenURL

  85. Allen NB, Hetrick SE, Simmons JG, Hickie IB: Early intervention for depressive disorders in young people: the opportunity and the (lack of) evidence.

    Med J Aust 2007, 187:S15. PubMed Abstract | Publisher Full Text OpenURL

  86. Hickie I, Scott E, Naismith S, Ward PB, Turner K, Parker G, Mitchell P, Wilhelm K: Late-onset depression: genetic, vascular and clinical contributions.

    Psychol Med 2001, 31:1403-1412. PubMed Abstract OpenURL

  87. Gillespie NA, Kirk KM, Evans DM, Heath AC, Hickie IB, Martin NG: Do the genetic or environmental determinants of anxiety and depression change with age? A longitudinal study of Australian twins.

    Twin Res 2004, 7:39-53. PubMed Abstract | Publisher Full Text OpenURL

  88. McGorry PD, Purcell R, Hickie IB, Yung AR, Pantelis C, Jackson HJ: Clinical staging: a heuristic model for psychiatry and youth mental health.

    Med J Aust 2007, 187:S40. PubMed Abstract | Publisher Full Text OpenURL

  89. Hickie I, Davenport T, Wakefield D, Vollmer-Conna U, Cameron B, Vernon SD, Reeves WC, Lloyd A, Dubbo Infection Outcomes Study Group: Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study.

    BMJ 2006, 333:575. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  90. Avenevoli S, Merikangas KR: Implications of high-risk family studies for prevention of depression.

    Am J Prevent Med 2006, 31:126-135. Publisher Full Text OpenURL

  91. Merikangas KR, Lieb R, Wittchen HU, Avenevoli S: Family and high-risk studies of social anxiety disorder.

    Acta Psychiatr Scand Suppl 2003, 417:28-37. PubMed Abstract OpenURL

  92. Preisig M, Fenton BT, Stevens DE, Merikangas KR: Familial relationship between mood disorders and alcoholism.

    Compr Psychiatry 2001, 42:87-95. PubMed Abstract | Publisher Full Text OpenURL

  93. Merikangas KR, Stolar M, Stevens DE, Goulet J, Preisig MA, Fenton B, Zhang H, O’Malley SS, Rounsaville BJ: Familial transmission of substance use disorders.

    Arch Gen Psychiatry 1998, 55:973-979. PubMed Abstract | Publisher Full Text OpenURL

  94. Milne BJ, Caspi A, Harrington H, Poulton R, Rutter M, Moffitt TE: Predictive value of family history on severity of illness: the case for depression, anxiety, alcohol dependence, and drug dependence.

    Arch Gen Psychiatry 2009, 66:738-747. PubMed Abstract | Publisher Full Text OpenURL

  95. Angst J, Azorin J-M, Bowden CL, Perugi G, Vieta E, Gamma A, Young AH, for the BSG: Prevalence and characteristics of undiagnosed bipolar disorders in patients with a major depressive episode: The BRIDGE study.

    Arch Gen Psychiatry 2011, 68:791-799. PubMed Abstract | Publisher Full Text OpenURL

  96. Boyce P, Hickie I, Parker G: Parents, partners or personality? Risk factors for post-natal depression.

    J Affect Disord 1991, 21:245-255. PubMed Abstract | Publisher Full Text OpenURL

  97. Hickie I, Parker G: The impact of an uncaring partner on improvement in non-melancholic depression.

    J Affect Disord 1992, 25:147-160. PubMed Abstract | Publisher Full Text OpenURL

  98. Hickie I, Parker G, Wilhelm K, Tennant C: Perceived interpersonal risk factors of non-endogenous depression.

    Psychol Med 1991, 21:399-412. PubMed Abstract | Publisher Full Text OpenURL

  99. Hansell NK, Wright MJ, Medland SE, Davenport TA, Wray NR, Martin NG, Hickie IB: Genetic co-morbidity between neuroticism, anxiety/depression and somatic distress in a population sample of adolescent and young adult twins.

    Psychol Med 2012, 42:1249-1260. PubMed Abstract | Publisher Full Text OpenURL

  100. Chiang M-C, McMahon KL, de Zubicaray GI, Martin NG, Hickie I, Toga AW, Wright MJ, Thompson PM: Genetics of white matter development: a DTI study of 705 twins and their siblings aged 12 to 29.

    Neuroimage 2011, 54:2308-2317. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  101. Merikangas KR, Lamers F: The ‘true’ prevalence of bipolar II disorder.

    Curr Opin Psychiatry 2012, 25:19-23. PubMed Abstract | Publisher Full Text OpenURL

  102. Hetrick SE, Parker AG, Hickie IB, Purcell R, Yung AR, McGorry PD: Early identification and intervention in depressive disorders: towards a clinical staging model.

    Psychother Psychosom 2008, 77:263-270. PubMed Abstract | Publisher Full Text OpenURL

  103. Dubicka B, Elvins R, Roberts C, Chick G, Wilkinson P, Goodyer IM: Combined treatment with cognitive-behavioural therapy in adolescent depression: meta-analysis.

    Br J Psychiatry 2010, 197:433-440. PubMed Abstract | Publisher Full Text OpenURL

  104. Asarnow JR, Emslie G, Clarke G, Wagner KD, Spirito A, Vitiello B, Iyengar S, Shamseddeen W, Ritz L, Birmaher B, Ryan N, Kennard B, Mayes T, DeBar L, McCracken J, Strober M, Suddath R, Leonard H, Porta G, Keller M, Brent D: Treatment of selective serotonin reuptake inhibitor-resistant depression in adolescents: predictors and moderators of treatment response.

    J Am Acad Child Adolesc Psychiatry 2009, 48:330-339. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  105. Curry J, Rohde P, Simons A, Silva S, Vitiello B, Kratochvil C, Reinecke M, Feeny N, Wells K, Pathak S, Weller E, Rosenberg D, Kennard B, Robins M, Ginsburg G, March J: Predictors and moderators of acute outcome in the Treatment for Adolescents with Depression Study (TADS).

    J Am Acad Child Adolesc Psychiatry 2006, 45:1427-1439. PubMed Abstract | Publisher Full Text OpenURL

  106. Hermens DF, Lagopoulos J, Naismith SL, Tobias-Webb J, Hickie IB: Distinct neurometabolic profiles are evident in the anterior cingulate of young people with major psychiatric disorders.

    Transl Psychiatry 2012, 2:e110. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  107. Libby AM, Orton HD, Stover SK, Riggs PD: What came first, major depression or substance use disorder? Clinical characteristics and substance use comparing teens in a treatment cohort.

    Addict Behav 2005, 30:1649-1662. PubMed Abstract | Publisher Full Text OpenURL

  108. Hermens DF, Lagopoulos J, Tobias-Webb J, De Regt T, Dore G, Juckes L, Latt N, Hickie IB: Pathways to alcohol-induced brain impairment in young people: a review.

    Cortex 2013, 49:3-17. PubMed Abstract | Publisher Full Text OpenURL

  109. Conway KP, Compton W, Stinson FS, Grant BF: Lifetime comorbidity of DSM-IV mood and anxiety disorders and specific drug use disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions.

    J Clin Psychiatry 2006, 67:247-257. PubMed Abstract | Publisher Full Text OpenURL

  110. Compton WM, Thomas YF, Conway KP, Colliver JD: Developments in the epidemiology of drug use and drug use disorders.

    Am J Psychiatry 2005, 162:1494-1502. PubMed Abstract | Publisher Full Text OpenURL

  111. Vieta E, Sanchez-Moreno J, Lahuerta J, Zaragoza S, Group E: Subsyndromal depressive symptoms in patients with bipolar and unipolar disorder during clinical remission.

    J Affect Disord 2008, 107:169-174. PubMed Abstract | Publisher Full Text OpenURL

  112. Wilcox HC, Anthony JC: Child and adolescent clinical features as forerunners of adult-onset major depressive disorder: retrospective evidence from an epidemiological sample.

    J Affect Disord 2004, 82:9-20. PubMed Abstract | Publisher Full Text OpenURL

  113. Dunlop BW, Binder EB, Cubells JF, Goodman MG, Kelley ME, Kinkead B, Kutner M, Nemeroff CB, Newport DJ, Owens MJ, Pace TW, Ritchie JC, Aponte Rivera V, Westen D, Craighead WE, Mayberg HS: Predictors of remission in depression to individual and combined treatments (PReDICT): study protocol for a randomized controlled trial.

    Trials 2012, 13:106. PubMed Abstract | BioMed Central Full Text | PubMed Central Full Text OpenURL

  114. Hickie I, Naismith S, Ward PB, Scott E, Mitchell P, Wilhelm K, Parker G: Vascular risk and low serum B12 predict white matter lesions in patients with major depression.

    J Affect Disord 2005, 85:327-332. PubMed Abstract | Publisher Full Text OpenURL

  115. Plante GE: Depression and cardiovascular disease: a reciprocal relationship.

    Metabolism 2005, 54:45-48. PubMed Abstract | Publisher Full Text OpenURL

  116. Camus V, Kraehenbuhl H, Preisig M, Bula CJ, Waeber G, Camus V, Kraehenbuhl H, Preisig M, Bula CJ, Waeber G: Geriatric depression and vascular diseases: what are the links?

    J Affect Disord 2004, 81:1-16. PubMed Abstract | Publisher Full Text OpenURL

  117. Barnes DE, Alexopoulos GS, Lopez OL, Williamson JD, Yaffe K, Barnes DE, Alexopoulos GS, Lopez OL, Williamson JD, Yaffe K: Depressive symptoms, vascular disease, and mild cognitive impairment: findings from the Cardiovascular Health Study.

    Arch Gen Psychiatry 2006, 63:273-279. PubMed Abstract | Publisher Full Text OpenURL

  118. Bruce DG, Casey G, Davis WA, Starkstein SE, Clarnette RC, Foster JK, Ives FJ, Almeida OP, Davis TM, Bruce DG, Casey G, Davis WA, Starkstein SE, Clarnette RC, Foster JK, Ives FJ, Almeida OP, Davis TME: Vascular depression in older people with diabetes.

    Diabetologia 2006, 49:2828-2836. PubMed Abstract | Publisher Full Text OpenURL

  119. Almeida OP, Flicker L, Norman P, Hankey GJ, Vasikaran S, van Bockxmeer FM, Jamrozik K: Association of cardiovascular risk factors and disease with depression in later life.

    Am J Geriatr Psychiatry 2007, 15:506-513. PubMed Abstract | Publisher Full Text OpenURL

  120. Meyers BS, Klimstra SA, Gabriele M, Hamilton M, Kakuma T, Tirumalasetti F, Alexopoulos GS, Meyers BS, Klimstra SA, Gabriele M, Hamilton M, Kakuma T, Tirumalasetti F, Alexopoulos GS: Continuation treatment of delusional depression in older adults.

    Am J Geriatr Psychiatry 2001, 9:415-422. PubMed Abstract OpenURL

  121. Monteleone P, Martiadis V, Maj M: Circadian rhythms and treatment implications in depression.

    Prog Neuropsychopharmacol Biol Psychiatry 2011, 35:1569-1574. PubMed Abstract | Publisher Full Text OpenURL

  122. Hickie IB, Rogers NL: Novel melatonin-based therapies: potential advances in the treatment of major depression.

    Lancet 2011, 378:621-631. PubMed Abstract | Publisher Full Text OpenURL

  123. Gorwood P: Restoring circadian rhythms: a new way to successfully manage depression.

    J Psychopharmacol 2010, 24:15-19. PubMed Abstract | Publisher Full Text OpenURL

  124. Monteleone P, Maj M: The circadian basis of mood disorders: recent developments and treatment implications.

    Eur Neuropsychopharmacol 2008, 18:701-711. PubMed Abstract | Publisher Full Text OpenURL

  125. Danaei G, Finucane MM, Lu Y, Singh GM, Cowan MJ, Paciorek CJ, Lin JK, Farzadfar F, Khang Y-H, Stevens GA, Rao M, Ali MK, Riley LM, Robinson CA, Ezzati M: National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants.

    Lancet 2011, 378:31-40. PubMed Abstract | Publisher Full Text OpenURL

  126. Tabak AG, Herder C, Rathmann W, Brunner EJ, Kivimaki M: Prediabetes: a high-risk state for diabetes development.

    Lancet 2012, 379:2279-2290. PubMed Abstract | Publisher Full Text OpenURL

  127. Perreault L, Pan Q, Mather KJ, Watson KE, Hamman RF, Kahn SE: Effect of regression from prediabetes to normal glucose regulation on long-term reduction in diabetes risk: results from the Diabetes Prevention Program Outcomes Study.

    Lancet 2012, 379:2243-2251. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  128. The Lancet: Prediabetes and the potential to prevent diabetes.

    Lancet 2012, 379:2213. PubMed Abstract | Publisher Full Text OpenURL

  129. Hickie IB, Fogarty AS, Davenport TA, Luscombe GM, Burns J: Responding to experiences of young people with common mental health problems attending Australian general practice.

    Med J Aust 2007, 187:S47. PubMed Abstract | Publisher Full Text OpenURL

  130. Hickie IB: Youth mental health: we know where we are and we can now say where we need to go next.

    Early Interv Psychiatry 2011, 5:63-69. PubMed Abstract | Publisher Full Text OpenURL

  131. Phillips J, Frances A, Cerullo M, Chardavoyne J, Decker H, First M, Ghaemi N, Greenberg G, Hinderliter A, Kinghorn W, LoBello S, Martin E, Mishara A, Paris J, Pierre J, Pies R, Pincus H, Porter D, Pouncey C, Schwartz M, Szasz T, Wakefield J, Waterman GS, Whooley O, Zachar P: The six most essential questions in psychiatric diagnosis: a pluralogue part 1: conceptual and definitional issues in psychiatric diagnosis.

    Philos Ethics Hum Med 2012, 7:3. BioMed Central Full Text OpenURL

  132. Tengs TO, Adams ME, Pliskin JS, Safran DG, Siegel JE, Weinstein MC, Graham JD: Five-hundred life-saving interventions and their cost-effectiveness.

    Risk Anal 1995, 15:369-390. PubMed Abstract | Publisher Full Text OpenURL

  133. Smith SC Jr, Collins A, Ferrari R, Holmes DR Jr, Logstrup S, McGhie DV, Ralston J, Sacco RL, Stam H, Taubert K, Wood DA, Zoghbi WA: Our time: a call to save preventable death from cardiovascular disease (heart disease and stroke).

    Circulation 2012, 60:2343-2348. OpenURL

  134. Banati RB, Hickie IB: Therapeutic signposts: using biomarkers to guide better treatment of schizophrenia and other psychotic disorders.

    Med J Aust 2009, 190:S26-S32. PubMed Abstract | Publisher Full Text OpenURL

  135. Hickie IB, McGorry PD: Characterising novel pathways to schizophrenia.

    Med J Aust 2009, 190:S5-S6. PubMed Abstract | Publisher Full Text OpenURL

  136. Kaur M, Battisti RA, Lagopoulos J, Ward PB, Hickie IB, Hermens DF: Neurophysiological biomarkers support bipolar-spectrum within psychosis cluster.

    J Psychiatry Neurosci 2012, 37:313-321. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  137. Andrews G, Titov N: Depression is very disabling.

    Lancet 2007, 370:808-809. PubMed Abstract | Publisher Full Text OpenURL

  138. Archie S, Zangeneh Kazemi A, Akhtar-Danesh N: Concurrent binge drinking and depression among Canadian youth: prevalence, patterns, and suicidality.

    Alcohol 2012, 46:165-172. PubMed Abstract | Publisher Full Text OpenURL

  139. Boden JM, Fergusson DM: Alcohol and depression.

    Addiction 2011, 106:906-914. PubMed Abstract | Publisher Full Text OpenURL

  140. Bond L, Toumbourou JW, Thomas L, Catalano RF, Patton G: Individual, family, school, and community risk and protective factors for depressive symptoms in adolescents: a comparison of risk profiles for substance use and depressive symptoms.

    Prev Sci 2005, 6:73-88. PubMed Abstract | Publisher Full Text OpenURL

  141. Bunker SJ, Colquhoun DM, Esler MD, Hickie IB, Hunt D, Jelinek VM, Oldenburg BF, Peach HG, Ruth D, Tennant CC, Tonkin AM: “Stress” and coronary heart disease: psychosocial risk factors.

    Med J Aust 2003, 178:272-276. PubMed Abstract | Publisher Full Text OpenURL

  142. Goldberg D, Fawcett J: The importance of anxiety in both major depression and bipolar disorder.

    Dep Anxiety 2012, 29:471-478. Publisher Full Text OpenURL

  143. Simms LJ, Prisciandaro JJ, Krueger RF, Goldberg DP: The structure of depression, anxiety and somatic symptoms in primary care.

    Psychol Med 2012, 42:15-28. PubMed Abstract | Publisher Full Text OpenURL

  144. Goldberg DP, Andrews G, Hobbs MJ: Where should bipolar disorder appear in the meta-structure?

    Psychol Med 2009, 39:2071-2081. PubMed Abstract | Publisher Full Text OpenURL

  145. Andrews G, Goldberg DP, Krueger RF, Carpenter WT, Hyman SE, Sachdev P, Pine DS: Exploring the feasibility of a meta-structure for DSM-V and ICD-11: could it improve utility and validity?

    Psychol Med 2009, 39:1993-2000. PubMed Abstract | Publisher Full Text OpenURL

  146. Cuthbert BN, Insel TR: Toward new approaches to psychotic disorders: the NIMH Research Domain Criteria Project.

    Schizophr Bull 2010, 36:1061-1062. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  147. Pesa N, Hermens D, Battisti R, Kaur M, Hickie I, Solowij N: Delayed preattentional functioning in early psychosis patients with cannabis use.

    Psychopharmacology (Berl) 2012, 222:507-518. Publisher Full Text OpenURL

  148. Chitty KM, Kaur M, Lagopoulos J, Hickie IB, Hermens DF: Alcohol use and mismatch negativity in young subjects with psychotic disorder.

    Neuroreport 2011, 17:918-922. OpenURL

  149. The APA Task Force on Laboratory Tests in Psychiatry: The dexamethasone suppression test: an overview of its current status in psychiatry.

    Am J Psychiatry 1987, 144:1253-1262. PubMed Abstract | Publisher Full Text OpenURL

  150. Kaur M, Battisti RA, Ward PB, Ahmed A, Hickie IB, Hermens DF: MMN/P3a deficits in first episode psychosis: comparing schizophrenia-spectrum and affective-spectrum subgroups.

    Schizophr Res 2011, 130:203-209. PubMed Abstract | Publisher Full Text OpenURL

  151. Hermens DF, Ward PB, Hodge MAR, Kaur M, Naismith SL, Hickie IB: Impaired MMN/P3a complex in first-episode psychosis: cognitive and psychosocial associations.

    Prog Neuropsychopharmacol Biol Psychiatry 2010, 34:822-829. PubMed Abstract | Publisher Full Text OpenURL

  152. Caspi A, Moffitt TE: Gene-environment interactions in psychiatry: joining forces with neuroscience.

    Nat Rev Neurosci 2006, 7:583-590. PubMed Abstract | Publisher Full Text OpenURL

  153. Kuepper R, Myin-Germeys I, Konings M, van Winkel R, van Os J, Henquet C: Exploring the causal relationship between cannabis and schizophrenia: what is the role of genes and environment?

    Eur Psychiatry 2009, 24:S31-S31. OpenURL

  154. Henquet C, Di Forti M, Morrison P, Kuepper R, Murray RM: Gene-environment interplay between cannabis and psychosis.

    Schizophr Bull 2008, 34:1111-1121. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  155. Illi J, Miaskowski C, Cooper B, Levine JD, Dunn L, West C, Dodd M, Dhruva A, Paul SM, Baggott C, Cataldo J, Langford D, Schmidt B, Aouizerat BE: Association between pro- and anti-inflammatory cytokine genes and a symptom cluster of pain, fatigue, sleep disturbance, and depression.

    Cytokine 2012, 58:437-447. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  156. Bennett B, Goldstein D, Friedlander M, Hickie I, Lloyd A: The experience of cancer-related fatigue and chronic fatigue syndrome: a qualitative and comparative study.

    J Pain Symptom Manage 2007, 34:126-135. PubMed Abstract | Publisher Full Text OpenURL

  157. Scott J: Bipolar disorder: from early identification to personalized treatment.

    Early Interv Psychiatry 2011, 5:89-90. PubMed Abstract | Publisher Full Text OpenURL

  158. Scott JAN, Paykel E, Morriss R, Bentall R, Kinderman P, Johnson T, Abbott R, Hayhurst H: Cognitive-behavioural therapy for severe and recurrent bipolar disorders.

    Br J Psychiatry 2006, 188:313-320. PubMed Abstract | Publisher Full Text OpenURL

  159. McGorry PD: Is early intervention in the major psychiatric disorders justified? Yes.

    BMJ 2008, 337:a695. PubMed Abstract | Publisher Full Text OpenURL

  160. Hickie I: Is depression overdiagnosed? No.

    BMJ 2007, 335:329. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  161. Parker G: Is depression overdiagnosed? Yes.

    BMJ 2007, 335:328. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  162. McGorry PD, Yung AR, Pantelis C, Hickie IB: A clinical trials agenda for testing interventions in earlier stages of psychotic disorders.

    Med J Aust 2009, 190:S33-S36. PubMed Abstract | Publisher Full Text OpenURL

  163. McGorry PD, Nelson B, Amminger GP, Bechdolf A, Francey SM, Berger G, Riecher-Rossler A, Klosterkotter J, Ruhrmann S, Schultze-Lutter F, Nordentoft M, Hickie I, McGuire P, Berk M, Chen EYH, Keshavan MS, Yung AR: Intervention in individuals at ultra-high risk for psychosis: a review and future directions.

    J Clin Psychiatry 2009, 70:1206-1212. PubMed Abstract | Publisher Full Text OpenURL

  164. Hickie IB, Banati RB, Stewart CH, Lloyd AR: Are common childhood or adolescent infections risk factors for schizophrenia and other psychotic disorders?

    Med J Aust 2009, 190:S17-S21. PubMed Abstract | Publisher Full Text OpenURL

  165. Kantomaa MT, Tammelin TH, Ebeling HE, Taanila AM: Emotional and behavioral problems in relation to physical activity in youth.

    Med Sci Sports Exerc 2008, 40:1749-1756. PubMed Abstract | Publisher Full Text OpenURL

  166. Ichiki M, Kunugi H, Takei N, Murray RM, Baba H, Arai H, Oshima I, Okagami K, Sato T, Hirose T, Nanko S: Intra-uterine physical growth in schizophrenia: evidence confirming excess of premature birth.

    Psychol Med 2000, 30:597-604. PubMed Abstract | Publisher Full Text OpenURL

  167. Licinio J, Wong ML: Advances in depression research: 2011.

    Mol Psychiatry 2011, 16:686-687. PubMed Abstract | Publisher Full Text OpenURL

  168. Glozier N, Martiniuk A, Patton G, Ivers R, Li Q, Hickie I, Senserrick T, Woodward M, Norton R, Stevenson M: Short sleep duration in prevalent and persistent psychological distress in young adults: the DRIVE study.

    Sleep 2010, 33:1139-1145. PubMed Abstract | PubMed Central Full Text OpenURL

  169. Pjrek E, Winkler D, Konstantinidis A, Willeit M, Praschak-Rieder N, Kasper S: Agomelatine in the treatment of seasonal affective disorder.

    Psychopharmacology (Berl) 2007, 190:575-579. Publisher Full Text OpenURL

  170. Schwarz PE, Reimann M, Li J, Bergmann A, Licinio J, Wong ML, Bornstein SR: The metabolic syndrome - a global challenge for prevention.

    Horm Metab Res 2007, 39:777-780. PubMed Abstract | Publisher Full Text OpenURL

  171. Kasper S, Hajak G, Wulff K, Hoogendijk WJ, Montejo AL, Smeraldi E, Rybakowski JK, Quera-Salva MA, Wirz-Justice AM, Picarel-Blanchot F, Bayle FJ: Efficacy of the novel antidepressant agomelatine on the circadian rest-activity cycle and depressive and anxiety symptoms in patients with major depressive disorder: a randomized, double-blind comparison with sertraline.

    J Clin Psychiatry 2010, 71:109-120. PubMed Abstract | Publisher Full Text OpenURL

  172. Ehlers CL, Kupfer DJ, Frank E, Monk TH: Biological rhythms and depression: the role of zeitgebers and zeitstoreres.

    Depression 1993, 1:285-293. Publisher Full Text OpenURL

  173. Terman M, Terman JS: Light therapy for seasonal and nonseasonal depression: efficacy, protocol, safety, and side effects.

    CNS Spectr 2005, 10:647-663.

    quiz 672

    PubMed Abstract OpenURL

  174. Barbini B, Benedetti F, Colombo C, Dotoli D, Bernasconi A, Cigala-Fulgosi M, Florita M, Smeraldi E: Dark therapy for mania: a pilot study.

    Bipolar Disord 2005, 7:98-101. PubMed Abstract | Publisher Full Text OpenURL

  175. Quera Salva MA, Vanier B, Laredo J, Hartley S, Chapotot F, Moulin C, Lofaso F, Guilleminault C: Major depressive disorder, sleep EEG and agomelatine: an open-label study.

    Int J Neuropsychopharmacol 2007, 10:691-696. PubMed Abstract | Publisher Full Text OpenURL

  176. Mansour HA, Monk TH, Nimgaonkar VL: Circadian genes and bipolar disorder.

    Ann Med 2005, 37:196-205. PubMed Abstract | Publisher Full Text OpenURL

  177. McCarthy MJ, Nievergelt CM, Kelsoe JR, Welsh DK: A survey of genomic studies supports association of circadian clock genes with bipolar disorder spectrum illnesses and lithium response.

    PLoS One 2012, 7:e32091. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  178. Mukherjee S, Coque L, Cao JL, Kumar J, Chakravarty S, Asaithamby A, Graham A, Gordon E, Enwright JF 3rd, DiLeone RJ, Birnbaum SG, Cooper DC, McClung CA: Knockdown of Clock in the ventral tegmental area through RNA interference results in a mixed state of mania and depression-like behavior.

    Biol Psychiatry 2010, 68:503-511. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  179. Coque L, Mukherjee S, Cao JL, Spencer S, Marvin M, Falcon E, Sidor MM, Birnbaum SG, Graham A, Neve RL, Gordon E, Ozburn AR, Goldberg MS, Han MH, Cooper DC, McClung CA: Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behavior in the ClockDelta19 mouse model of mania.

    Neuropsychopharmacology 2011, 36:1478-1488. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  180. Solberg LC, Horton TH, Turek FW: Circadian rhythms and depression: effects of exercise in an animal model.

    Am J Physiol 1999, 276:R152-R161. PubMed Abstract | Publisher Full Text OpenURL

  181. Kaladchibachi SA, Doble B, Anthopoulos N, Woodgett JR, Manoukian AS: Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link in the therapeutic action of lithium.

    J Circ Rhythms 2007, 5:3. BioMed Central Full Text OpenURL

  182. Yagita K, Tamanini F, van Der Horst GT, Okamura H: Molecular mechanisms of the biological clock in cultured fibroblasts.

    Science 2001, 292:278-281. PubMed Abstract | Publisher Full Text OpenURL

  183. Yang S, Van Dongen HP, Wang K, Berrettini W, Bucan M: Assessment of circadian function in fibroblasts of patients with bipolar disorder.

    Mol Psychiatry 2009, 14:143-155. PubMed Abstract | Publisher Full Text OpenURL

  184. Ito N, Ito T, Kromminga A, Bettermann A, Takigawa M, Kees F, Straub RH, Paus R: Human hair follicles display a functional equivalent of the hypothalamic-pituitary-adrenal axis and synthesize cortisol.

    FASEB J 2005, 19:1332-1334. PubMed Abstract | Publisher Full Text OpenURL

  185. Raul JS, Cirimele V, Ludes B, Kintz P: Detection of physiological concentrations of cortisol and cortisone in human hair.

    Clin Biochem 2004, 37:1105-1111. PubMed Abstract | Publisher Full Text OpenURL

  186. Licinio J: Translational psychiatry: leading the transition from the cesspool of devastation to a place where the grass is really greener.

    Transl Psychiatry 2011, 1:e1. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  187. Licinio J, Wong ML: Pharmacogenomics of antidepressants: what is next?

    Mol Psychiatry 2010, 15:445-445. PubMed Abstract | Publisher Full Text OpenURL

  188. Bornstein SR, Licinio J: Improving the efficacy of translational medicine by optimally integrating health care, academia and industry.

    Nat Med 2011, 17:1567-1569. PubMed Abstract | Publisher Full Text OpenURL

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