Open Access Research article

Serum biomarkers for neurofibromatosis type 1 and early detection of malignant peripheral nerve-sheath tumors

Su-Jin Park1, Birgit Sawitzki2, Lan Kluwe3, Victor F Mautner3, Nikola Holtkamp1 and Andreas Kurtz14*

Author Affiliations

1 Berlin-Brandenburg Center for Regenerative Therapies, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany

2 Institute for Clinical Immunology, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany

3 Experimental Tumor Research, Phakomatoses, Department of Neurology, Universitätsklinikum Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany

4 College of Veterinary Medicine, Seoul National University, 599 Gwanangno, Gwanak-gu, Seoul 151-742, Republic Korea

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BMC Medicine 2013, 11:109  doi:10.1186/1741-7015-11-109

Published: 23 April 2013

Additional files

Additional file 1:

List and detailed information of patient and control cohorts used in the study. Abbreviations: nd, not done.

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Additional file 2:

List of candidate markers selected by manual curation of published data and text. The proteins used in the screenings are shown in bold and italic [49-63].

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Additional file 3:

Reassessment of protein serum markers interferon (IFN)-γ, interleukin (IL)-6, tumor necrosis factor (TNF)-α, insulin-like growth factor binding protein (IGFBP) and Regulated upon activation, normal T-cell expressed and secreted (RANTES) by cytometric bead array (CBA) and ELISA (arbitrary serum concentration units). Between 11 and 15 randomly selected sera from the different NF1 groups (for IFN-γ, IL-6, TNF-α: all NF1 vs. control; for IGFBP and RANTES: NF1 with no PNF or MPNST, NF1 with only PNF- and NF1 with MPNST) and 5 control sera were tested as indicated (ND, not determined). Where available, associated protein array data are shown. Statistical analysis is shown for CBA/ELISA data (t-test).

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