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Open Access Editorial

Novel pebbles in the mosaic of autoimmunity

Carlo Perricone12, Nancy Agmon-Levin1 and Yehuda Shoenfeld13*

Author Affiliations

1 The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer 52621, Israel

2 Reumatologia, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy

3 Incumbent of the Laura Schwarz-Kip Chair for Research of Autoimmune Diseases, Tel-Aviv University, Tel Aviv, Israel

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BMC Medicine 2013, 11:101  doi:10.1186/1741-7015-11-101

Published: 4 April 2013

Abstract

Almost 25 years ago, the concept of the ‘mosaic of autoimmunity’ was introduced to the scientific community, and since then this concept has continuously evolved, with new pebbles being added regularly. We are now looking at an era in which the players of autoimmunity have changed names and roles. In this issue of BMC Medicine, several aspects of autoimmunity have been addressed, suggesting that we are now at the forefront of autoimmunity science. Within the environmental factors generating autoimmunity are now included unsuspected molecules such as vitamin D and aluminum. Some adjuvants such as aluminum are recognized as causal factors in the development of the autoimmune response. An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), has been recently described. This is the new wind blowing within the branches of autoimmunity, adding knowledge to physicians for helping patients with autoimmune disease.

Keywords:
Autoimmunity; Autoantibodies; Autoimmune/inflammatory syndrome induced by adjuvants (ASIA); Systemic lupus erythematosus; Vitamin D; Adjuvant