Table 1

Clinical characteristics of intracranial hemorrhage among patients of different types of hematological malignancies

Number of patients


Subtype

AML (n = 43)

APL (n = 9)

ALL (n = 5)

Lymphoma (n = 7)

Myeloma (n = 8)

P value


Age:

0.094

≥60 years

19

2

1

6

4

<60 years

24

7

4

1

4

Gender:

0.461

Male

32

5

2

4

5

Female

11

4

3

3

3

Underlying hypertension:

0.428

Yes

12

3

0

3

1

No

31

6

5

4

7

Diabetes mellitus:

0.274

Yes

3

1

0

2

0

No

40

8

5

5

8

Sepsis:

0.096

Yes

16

5

5

4

4

No

27

4

0

3

4

Post HSCT:

0.347

Yes

8

0

0

0

1

No

35

9

5

7

7

Disease status:

0.409

Remission

6

2

0

0

0

Active

37

7

5

7

8

CNS involvement:

<0.001

Yes

0

0

0

5

1

No

43

9

5

2

7

Leukocyte count:

0.642

≥100,000 cells/μl

9

2

0

1

0

<100,000 cells/μl

34

7

5

6

8

Platelet count:

0.560

≥20,000 cells/μl

27

6

3

6

4

<20,000 cells/μl

16

3

2

1

4

Prothrombin time:

0.493

INR ≥1.5

10

2

1

1

1

INR <1.5

32

7

4

6

7

Location:

Cerebral cortex

37

7

5

4

5

0.326

Basal ganglia

9

1

1

1

1

0.941

Brainstem

4

0

0

1

0

0.628

Cerebellum

4

2

0

1

3

0.213

Multiple

20

5

0

3

5

0.240

Type:

Intraparenchymal hemorrhage

35

7

5

4

5

0.336

Subarachnoid hemorrhage

8

2

2

0

3

0.349

Subdural hemorrhage

11

2

1

4

4

0.307

Epidural hemorrhage

1

0

0

0

2

0.041

Intraventricular hemorrhage

10

4

1

3

2

0.618


ALL = acute lymphoblastic leukemia; AML = acute myeloid leukemia; APL = acute promyelocytic leukemia; CNS = central nervous system; HSCT = hematopoietic stem cell transplantation; INR = international normalized ratio.

Chen et al. BMC Medicine 2012 10:97   doi:10.1186/1741-7015-10-97

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