Table 3

Tests of fixed effects in MMRM for measures of psychopathology and functioning.

Effect

F test

df

P value

F test

df

P value


Symptoms

YMRS †

MADRS Total Score†

Group

2.04

1, 113.4

.156

Group

0.26

1, 121.7

.610

Time

1.45

6, 285.4

.197

Time

3.15

6, 240.6

.005

Group by time

0.99

6, 285.4

.432

Group by time

0.44

6, 240.6

.855

BDRS †

Group

0.27

1, 124.8

.604

Time

3.83

6, 245.2

.001

Group by time

0.49

6, 245.2

.813

CGI-BP Severity Depression †

CGI-BP Improvement Depression †

Group

0.03

1, 126.0

.863

Group

0.14

1, 123.6

.709

Time

1.03

6, 197.4

.405

Time

2.43

6, 341.8

.026

Group by time

0.60

6, 197.4

.731

Group by time

0.54

6, 341.8

.777

CGI-BP Severity Mania †

CGI-BP Improvement Mania†

Group

0.01

1, 116.0

.935

Group

0.05

1, 124.3

.822

Time

0.38

6, 247.2

.893

Time

1.99

6, 303.2

.066

Group by time

0.75

6, 247.2

.614

Group by time

1.32

6, 303.2

.248

CGI-BP Severity Overall †

CGI-BP Improvement Overall†

Group

0.15

1, 122.7

.704

Group

0.05

1, 125.3

.828

Time

1.31

6, 201.0

.255

Time

3.10

6, 335.6

.006

Group by time

0.47

6, 201.0

.829

Group by time

0.38

6, 335.6

.893

Functioning

GAF

SOFAS

Group

1.60

1, 121.9

.209

Group

0.46

1, 121.7

.500

Time

2.90

6, 252.9

.010

Time

4.43

6, 311.8

<.001

Group by time

0.75

6, 252.9

.609

Group by time

0.95

6, 311.8

.460

LIFE-RIFT

SLICE-LIFE

Group

0.95

1, 121.4

.332

Group

0.12

1, 119.8

.732

Time

1.09

6, 242.0

.370

Time

0.86

6, 275.5

.525

Group by time

0.52

6, 242.0

.794

Group by time

0.62

6, 275.5

.714

QLESQ

Group

0.53

1, 123.2

.466

Time

1.99

6, 265.4

.067

Group by time

0.16

6, 265.4

.987


YMRS, Young Mania Rating Scale; MADRS, Montgomery-Asberg Depression Rating Scale; BDRS, Bipolar Depression Rating Scale; CGI-BP Clinical Global Impressions - Bipolar Disorder; GAF, Global Assessment of Functioning; SOFAS, Social and Occupational Assessment Scale; LIFE-RIFT, Range of Impaired Functioning Tool; SLICE-LIFE, Streamed Longitudinal Interval Clinical Evaluation of the Longitudinal Interview Follow-Up Evaluation; Q-LES-Q, Quality of Life Enjoyment and Satisfaction Questionnaire. † Inferential statistics based on logarithmic transformed data (plus constant) because of extreme positive skewness.

Berk et al. BMC Medicine 2012 10:91   doi:10.1186/1741-7015-10-91

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