Table 2 |
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|
Differences between groups NAC and placebo on scores at Week 8 (at randomization) in terms of symptoms and functioning. |
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|
Characteristics |
Descriptive statistic |
Total sample n = 149 |
NAC n = 76 |
Placebo n = 7 3 |
Test statistic |
Value |
df |
P |
|
|
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|
Symptoms |
||||||||
|
YMRSa |
M(SD) |
1.5 (2.1) |
1.7 (2.4) |
1.4 (1.9) |
t-test |
0.37 |
130 |
.716 |
|
MADRSb |
M(SD) |
12.6 (9.8) |
13.1 (9.72) |
12.2 (9.9) |
t-test |
0.47 |
130 |
.638 |
|
BDRSa |
M(SD) |
10.7 (9.1) |
11.3 (8.5) |
10.1 (9.7) |
t-test |
1.20 |
130 |
.233 |
|
CGI-BP Severity |
||||||||
|
Depressiona |
M(SD) |
2.8 (1.2) |
2.9 (1.2) |
2.8 (1.2) |
t-test |
0.49 |
129 |
.625 |
|
Maniaa |
M(SD) |
1.3 (0.7) |
1.4 (0.7) |
1.3 (0.6) |
t-test |
0.17 |
129 |
.620 |
|
Overalla |
M(SD) |
2.9 (1.2) |
2.9 (1.2) |
2.8 (1.2) |
t-test |
0.29 |
128 |
.771 |
|
CGI-BP Improvement |
||||||||
|
Depressiona |
M(SD) |
2.5 (1.2) |
2.5 (1.1) |
2.6 (1.3) |
t-test |
-0.17 |
129 |
.864 |
|
Maniaa |
M(SD) |
3.8 (0.7) |
3.8 (0.7) |
3.9 (0.7) |
t-test |
-0.63 |
130 |
.533 |
|
Overalla |
M(SD) |
2.6 (1.2) |
2.6 (1.2) |
2.7 (1.3) |
t-test |
-0.30 |
129 |
.767 |
|
Functioning |
||||||||
|
GAF |
M(SD) |
72.2 (13.7) |
71.1 (13.3) |
73.3 (14.1) |
t-test |
-0.92 |
129 |
.360 |
|
SOFAS |
M(SD) |
72.1 (13.6) |
71.5 (13.0) |
72.6 (14.1) |
t-test |
-0.46 |
129 |
.649 |
|
LIFE-RIFT |
M(SD) |
11.2 (3.8) |
11.5 (3.9) |
10.9 (3.8) |
t-test |
0.83 |
130 |
.410 |
|
SLICE-LIFE |
M(SD) |
16.5 (5.2) |
16.6 (5.3) |
16.5 (5.0) |
t-test |
0.17 |
130 |
.866 |
|
Q-LES-Q |
M(SD) |
53.4 (10.8) |
52.5 (10.6) |
54.3 (11.0) |
t-test |
-0.98 |
130 |
.325 |
|
|
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|
YMRS, Young Mania Rating Scale; MADRS, Montgomery-Asberg Depression Rating Scale; BDRS, Bipolar Depression Rating Scale; CGI-BP Clinical Global Impressions - Bipolar Disorder; GAF, Global Assessment of Functioning; SOFAS, Social and Occupational Assessment Scale; Q-LES-Q, Quality of Life Enjoyment and Satisfaction Questionnaire. aInferential statistics based on logarthmic transformed data (plus constant) because of extreme positive skewness. Untransformed descriptive statistics are reported; bInferential statistics based on square root transformed data (plus constant) because of positive skewness. Untransformed descriptive statistics are reported. |
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|
Berk et al. BMC Medicine 2012 10:91 doi:10.1186/1741-7015-10-91 |
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