Table 2

Differences between groups NAC and placebo on scores at Week 8 (at randomization) in terms of symptoms and functioning.

Characteristics

Descriptive statistic

Total sample

n = 149

NAC

n = 76

Placebo

n = 7 3

Test statistic

Value

df

P


Symptoms

YMRSa

M(SD)

1.5 (2.1)

1.7 (2.4)

1.4 (1.9)

t-test

0.37

130

.716

MADRSb

M(SD)

12.6 (9.8)

13.1 (9.72)

12.2 (9.9)

t-test

0.47

130

.638

BDRSa

M(SD)

10.7 (9.1)

11.3 (8.5)

10.1 (9.7)

t-test

1.20

130

.233

CGI-BP Severity

Depressiona

M(SD)

2.8 (1.2)

2.9 (1.2)

2.8 (1.2)

t-test

0.49

129

.625

Maniaa

M(SD)

1.3 (0.7)

1.4 (0.7)

1.3 (0.6)

t-test

0.17

129

.620

Overalla

M(SD)

2.9 (1.2)

2.9 (1.2)

2.8 (1.2)

t-test

0.29

128

.771

CGI-BP Improvement

Depressiona

M(SD)

2.5 (1.2)

2.5 (1.1)

2.6 (1.3)

t-test

-0.17

129

.864

Maniaa

M(SD)

3.8 (0.7)

3.8 (0.7)

3.9 (0.7)

t-test

-0.63

130

.533

Overalla

M(SD)

2.6 (1.2)

2.6 (1.2)

2.7 (1.3)

t-test

-0.30

129

.767

Functioning

GAF

M(SD)

72.2 (13.7)

71.1 (13.3)

73.3 (14.1)

t-test

-0.92

129

.360

SOFAS

M(SD)

72.1 (13.6)

71.5 (13.0)

72.6 (14.1)

t-test

-0.46

129

.649

LIFE-RIFT

M(SD)

11.2 (3.8)

11.5 (3.9)

10.9 (3.8)

t-test

0.83

130

.410

SLICE-LIFE

M(SD)

16.5 (5.2)

16.6 (5.3)

16.5 (5.0)

t-test

0.17

130

.866

Q-LES-Q

M(SD)

53.4 (10.8)

52.5 (10.6)

54.3 (11.0)

t-test

-0.98

130

.325


YMRS, Young Mania Rating Scale; MADRS, Montgomery-Asberg Depression Rating Scale; BDRS, Bipolar Depression Rating Scale; CGI-BP Clinical Global Impressions - Bipolar Disorder; GAF, Global Assessment of Functioning; SOFAS, Social and Occupational Assessment Scale; Q-LES-Q, Quality of Life Enjoyment and Satisfaction Questionnaire. aInferential statistics based on logarthmic transformed data (plus constant) because of extreme positive skewness. Untransformed descriptive statistics are reported; bInferential statistics based on square root transformed data (plus constant) because of positive skewness. Untransformed descriptive statistics are reported.

Berk et al. BMC Medicine 2012 10:91   doi:10.1186/1741-7015-10-91

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