Table 7

Summary of clinical studies with bioabsorbable membranes for reconstruction of long bone defects

Author/Year [ref]

Study design

No of patients

Site

Size of defect

Etiology

Type of membrane

Graft

Type of fixation

Evaluation

Outcome


Meining 2010 [13]

case series

Six

Tibia (five)

Femur (one)

≥ CSD

Trauma

poly(L/DL-lactide)

80/20% membranes with 50 to 70

μm pore size

RIA, ICBG

IMN, plating

X-rays

Healing

one case: re-grafting after 15 months



Ip

2004 [134]

case series

Ten

Not reported

≤ 6 cm

Benign tumor, Osteomyelitis and trauma

polymeric scaffolds (sponges, 450 to 700 μm pore size) impregnated with bone marrow

Not reported

X-rays

Presence of bone regeneration and satisfactory function


CSD, critical size defect; ICBG, iliac crest bone graft; IMN, intermedullary nailing; RIA, Reamer/Irrigator/Aspirator.

Dimitriou et al. BMC Medicine 2012 10:81   doi:10.1186/1741-7015-10-81

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