Table 6

Summary of clinical studies with bioresorbable membranes for reconstruction of segmental mandibular defects

Author/Year [ref]

Study design

No. of pts

Mandibular reconstruction

Defect size

Etiology

Type of membrane

Graft

Type of fixation

Outcome


Kinoshita

2004 [33]

case series (1995 to 2001)

62

Mandibulectomy (segmental defect and hemimandibulectomy)

_

malignant (22) and benign (30) tumors, cysts (5), osteomyelitis (2), alveolar atrophy (1) trauma (2)

Absorbable

PLLA mesh

Autologous cancellous bone graft

+ bone marrow

+/- stainless steel wires

At six months post-operation:

Excellent (markedly effective) 56.5%

Good (effective) 27.4%

Poor (not effective) 16.1%

X-ray of the regenerated bone: 0 to 10% bone resorption in 31 cases

10% to 20% in six cases

20% to 30% in one case



Kinoshita

2000 [133]

case series (1995 to 1998)

41

Segmental defect or large partial defects mandibulectomy

_

malignant (19) and benign (22) tumors

-

Excellent: 19/41 (46.3%)

Good 13/41 (31.7%)

Poor 9/41 (22.2%) (local infection)

86.5% Success rate

Five years: no problems from PLLA and good osseointegration



Kinoshita

1996 [57]

case series

2

Segmental defect or large partial defect

right to left molar areas

tumor

stainless steel wires

At three months: full bone regeneration


Dimitriou et al. BMC Medicine 2012 10:81   doi:10.1186/1741-7015-10-81

Open Data